Climate change is exacerbating the risk of the occurrence of extreme weather. This study has projected the change in mean and extreme climate conditions in Central Poland during near-future (2026–2050), mid-term (2051–2075), and far-future (2076–2100) periods under two climate-change scenarios in six General Circulation Models (GCMs) from Coupled Model Intercomparison Project Phase 6 (CMIP6). The results showed that, compared to the historical reference period (1990–2014), Central Poland will experience an increase in temperature and precipitation by the end of the twenty-first century. It is expected that the mean annual temperature and mean annual precipitation totals will increase by 1–4.8 °C and 2–7.5%, respectively. Furthermore, it is projected that the average number of hot, very hot days and extremely hot days (Tmax > 25 °C, > 30 °C, and > 35 °C), tropical nights (Tmin > 20 °C), and extremely high daily precipitation (> 10 mm, > 20 mm and > 30 mm) will also increase, while the average number of slight frost days (Tmin < 0 °C), and frost and severe frost days (Tmax < 0 °C, Tmax < − 10 °C) will decline on average by the end of the twenty-first century. Therefore, it is essential for policymakers to take some appropriate measurements and strategies in advance to strengthen resilience to extreme climate events.