Projections of the Vestibular and Cerebellar Nuclei in &lt;i&gt;Rana pipiens&lt;/i&gt;

Montgomery, Neil

doi:10.1159/000116577

Cited by 39 publications

(31 citation statements)

References 30 publications

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“…In adult frogs, this cell-dense region has been subdivided and given numerous names by various investigators (Will and Fritzsch, 1988;Christensen-Dalsgaard and Walkowiak, 1999;McCormick, 1999). Because of difficulties in translating boundaries from adult to larval brains with the limited anatomical and physiological data currently available, we label this area, bounded medially by the fourth ventricle, laterally by the LLnp, and ventrally by the LLa, as the medial vestibular nucleus (MVN), consistent with the terminology used by Matesz (1979), Montgomery (1988), and Birinyi et al (2001) in adult Rana.…”

Section: Electrophysiological Responsesmentioning

confidence: 79%

Multiple Mechanosensory Modalities Influence Development of Auditory Function

Horowitz¹,

Tanyu²,

Simmons³

2007

J. Neurosci.

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Sensory development can be dependent on input from multiple modalities. During metamorphic development, ranid frogs exhibit rapid reorganization of pathways mediating auditory, vestibular, and lateral line modalities as the animal transforms from an aquatic to an amphibious form. Here we show that neural sensitivity to the underwater particle motion component of sound follows a different developmental trajectory than that of the pressure component. Throughout larval stages, cells in the medial vestibular nucleus show best frequencies to particle motion in the range from 15 to 65 Hz, with displacement thresholds of Ͻ10 m. During metamorphic climax, best frequencies significantly increase, and sensitivity to lower-frequency (Ͻ25 Hz) stimuli tends to decline. These findings suggest that continued sensitivity to particle motion may compensate for the considerable loss of sensitivity to pressure waves observed during the developmental deaf period. Transport of a lipophilic dye from peripheral end organs to the dorsal medulla shows that fibers from the saccule in the inner ear and from the anterior lateral line both terminate in the medial vestibular nucleus. Saccular projections remain stable across larval development, whereas lateral line projections degenerate during metamorphic climax. Sensitivity to particle motion may be based on multimodal input early in development and on saccular input alone during the transition to amphibious life.

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Section: Electrophysiological Responsesmentioning

confidence: 79%

Multiple Mechanosensory Modalities Influence Development of Auditory Function

Horowitz¹,

Tanyu²,

Simmons³

2007

J. Neurosci.

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“…Instead, we use the term MVN to be consistent with the terminology used in adult Rana by Montgomery [1988] and Matesz et al [2002]; these authors do not differentiate a separate caudal nucleus. The LVN as identified in this study has been termed the vestibular nucleus, Deiters nucleus or the ventral nucleus of the eighth nerve [Matesz, 1979;Fritzsch et al 1984;Montgomery, 1988]; its dorsal area also includes what Matesz [1979] termed the saccular nucleus. We do not distinguish a separate saccular nucleus in our material.…”

Section: Anatomical Boundaries and Terminologymentioning

confidence: 98%

“…Nuclear boundaries in the tadpole and froglet brains are based on our own in-house atlases, supplemented by relevant literature from other laboratories Rubinson, 1983, 1984;Fritzsch et al, 1984]. Boundaries in the adult brain are based on Matesz [1979], Wilczynski [1981], Montgomery [1988], Will and Fritzsch [1988], Feng and Lin [1991], McCormick [1999] and Matesz et al [2002]. The DMN has been variously called the nucleus cochlearis [Larsell, 1934;Matesz, 1979], the acoustic nucleus [Jacoby and Rubinson, 1983] and the dorsal lateral nucleus Chapman et al, 2006].…”

Section: Anatomical Boundaries and Terminologymentioning

confidence: 99%

Plasticity of Auditory Medullary-Midbrain Connectivity across Metamorphic Development in the Bullfrog, <i>Rana catesbeiana</i>

Horowitz¹,

Chapman²,

Simmons³

2006

Brain Behav Evol

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On the basis of patterns of anterograde, retrograde, and bi-directional transport of tracers from both the superior olivary nucleus (SON) and the torus semicircularis (TS), we report anatomical changes in brainstem connectivity across metamorphic development in the bullfrog, Rana catesbeiana. In early and late stages of larval development (Gosner stages 25–37), anterograde or bi-directional tracers injected into the SON produce terminal/fiber label in the contralateral SON and in the ipsilateral TS. Between stages 38–41 (deaf period), only sparse or no terminal/fiber label is visible in these target nuclei. During metamorphic climax (stages 42–46), terminal/fiber label reappears in both the contralateral SON and in the ipsilateral TS, and now also in the contralateral TS. Injections of retrograde tracers into the SON fail to label cell bodies in the ipsilateral TS in deaf period animals, mirroring the previously-reported failure of retrograde transport from the TS to the ipsilateral SON during this developmental time. Bilateral cell body label emerges in the dorsal medullary nucleus and the lateral vestibular nucleus bilaterally as a result of SON transport during the late larval period, while cell body label in the contralateral TS emerges during climax. At all larval stages, injections into the SON produce anterograde and retrograde label in the medial vestibular nucleus bilaterally. These data show anatomical stability in some pathways and plasticity in others during larval development, with the most dramatic changes occurring during the deaf period and metamorphic climax. Animals in metamorphic climax show patterns of connectivity similar to that of froglets and adults, indicating the maturation during climax of central anatomical substrates for hearing in air.

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“…Moreover, secondary vestibular fibers (climbing fibers) from vestibular nuclei are distributed in the granule cell layer of the lobus vestibularis and corpus cerebelli, and in the molecular layer of both sides, terminating on the Purkinje cell dendrites. In turn, Purkinje cells axons terminate on the cerebellar and statoacoustic nuclei (Gregory, 1974;Nieuwenhuys and Opdam, 1976;Kuruvilla et al, 1985;Montgomery, 1988;ten Donkelaar, 1998).…”

Section: Nos Induction After Axotomymentioning

confidence: 99%

Nitric oxide synthase in the frog cerebellum: Response of Purkinje neurons to unilateral eighth nerve transection

et al. 2002

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When vestibular damage occurs, nitric oxide synthase (NOS) expression in rat cerebellar flocculus is affected. Since compensation for postural symptoms occurs and Purkinje cells play an important role in movement coordination and motor learning, we analyzed in situ the induction of NOS in the Purkinje cell population of the cerebellum (corpus cerebelli) of frog after unilateral transection of the eighth statoacoustic nerve to gain insight into the role of NO in neural plasticity after injury. Three days after neurectomy, the early effects induced NADPH diaphorase reactivity in most of the Purkinje cells on the ipsilateral side, while on the contralateral side the highest labeling was observed at 15 days. This finding can give information on the dynamics of vestibular compensation, in which NOS involvement was investigated. At 30 days, NADPH diaphorase reactivity was present in a large number of Purkinje cells of the whole cerebellum, while at 60 days a down-regulation for NADPH diaphorase reactivity was evident. A similar trend was observed for NOS-immunoreactivity, which was still present at 60 days in a high percentage of Purkinje cells, mainly on the ipsilateral side. On the basis of cell density evaluations, it was proposed that the early induction of NOS after neurectomy was linked to the degeneration of a part of the Purkinje neurons, while the permanence of NOS labeling might be due to a neuroprotective role of NO in the restoration phase of the vestibular compensation process. Anat Rec 268: 73-83, 2002.

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Projections of the Vestibular and Cerebellar Nuclei in <i>Rana pipiens</i>

Cited by 39 publications

References 30 publications

Multiple Mechanosensory Modalities Influence Development of Auditory Function

Multiple Mechanosensory Modalities Influence Development of Auditory Function

Plasticity of Auditory Medullary-Midbrain Connectivity across Metamorphic Development in the Bullfrog, <i>Rana catesbeiana</i>

Nitric oxide synthase in the frog cerebellum: Response of Purkinje neurons to unilateral eighth nerve transection

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