Brazil has as the main economic base the exportation of agricultural and mineral commodities. These products are characterized by having a large quantity of production and low price. Given these facts, the saving generated along the supply chain are fundamental role in the marketing success of these products. In that context, this study aimed to find the most economic transport routes to the disposal of soybeans and iron ore and manganese from the state of Mato Grosso do Sul destined to exportation. For that were identified the places that generate as, and the transportation ways that exist up to now and the future ones, the terminals, transshipments and harbor for export. The methods used for this analysis were the generation of scenarios, models of cost of transport to the modes transport to road, rail and river, and geographic information system. The results obtained in this study indicate that options trades with the use of the waterway are those that have lower costs, with strong participation of the waterway Paraguay-Parana. It is suggested to future researches investigation of the transportation system studied the use of restrictions on capability and the inclusion of costs charged at seaports of exportation.