2010
DOI: 10.1637/8965-062009-reg.1
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Prokaryotic Recombinant Hemagglutinin-Neuraminidase Protein Enhances the Humoral Response and Efficacy of Commercial Newcastle Disease Vaccines in Chickens

Abstract: The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) plays an important role in the pathogenesis of Newcastle disease (ND). Recombinant HN (rHN) protein, produced either by direct injection of recombinant viruses containing HN gene or baculovirus expression systems, has been used to elicit immunity against NDV in chickens. In the present study, a 60.4-kDa rHN was expressed by a prokaryotic expression system and formulated into ND vaccines. Inclusion of rHN (10 microg/ml) into conventio… Show more

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