Prokinetic effect of a standardized yarrow (<i>Achillea millefolium</i>) extract and its constituent choline: studies in the mouse and human stomach

Borrelli, Francesca; Romano, Barbara; Fasolino, Ines; Tagliatatela-Scafati, O.; Aprea, Giovanni; Capasso, Raffaele; Capasso, Francesco; Bottazzi, Enrico Coppola; Izzo, Angelo A.

doi:10.1111/j.1365-2982.2011.01827.x

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…Choline (Borrelli et al , ), 1,3‐dicaffeoylquinic acid (DCQA), 1,4‐DCQA, apigenin 4‐O‐glucoside and luteolin 4‐O‐glucoside (Vitalini et al, ), 3,4‐DCQA (Benedek et al, ; Vitalini et al, ), 3,5‐DCQA (Innocenti et al, ; Benedek et al, ; Fraisse et al, ; Vitalini et al, ), 1, 5‐DCQA (Fraisse et al, ), 4, 5, DCQA (Benedek et al, ; Fraisse et al, ), chlorogenic acid (Tunón et al, ; Innocenti et al, ; Benetis et al, ; Fraisse et al, ; Vitalini et al, ), luteolin‐7‐β‐D‐Oglucuronide (Benedek et al, ), caffeic acid (Tunón et al, ; Wojdyło et al, ; Yassa et al, ; Pires et al, ), p‐coumaric acid and neochlorogenic acid (Wojdyło et al, ), ferulic acid (Tunón et al, ; Wojdyło et al, ) and stachydrine, carboxylic acid, salicylic acid, pyrocatechol, adenine, mandelic acid, methyl esters of caprylic‐linolenic‐ and undecylenic acid (Tunón et al, ) are the phenols reported from different parts of A. mellifolium .…”

Section: Chemical Constituents Of a Millefoliummentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names. Monoterpenes are the most representative metabolites constituting 90% of the essential oils in relation to the sesquiterpenes, and a wide range of chemical compounds have also been reported. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of A. millefoilum with antiinflammatory, antiulcer, anticancer activities etc. lending support to the rationale behind numerous of its traditional uses. Due to the noteworthy pharmacological activities, A. millefoilum will be a better option for new drug discovery. The present review will comprehensively summarize the pharmacognosy, phytochemistry and ethnopharmacology of A. millefoilum reported to date, with emphasis on more in vitro, clinical and pathological studies needed to investigate the unexploited potential of this plant. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Chemical Constituents Of a Millefoliummentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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“…The antioxidant and antimicrobial properties and the chemical profile of the essential oil obtained from A. millefolium have also been reported. Flavonoids, phenolic acids and sesquiterpene lactones are considered to be the most important groups of pharmacologically active compounds present in Achillea species [9][10][11][12] . The chemical composition of Achillea species has been analyzed in detail and extracts of this plant have been demonstrated to contain a number of pharmacological active ingredients, including alkaloids, such as choline, and flavonoids such as rutin and apigenin.…”

Section: In Vitro Efficacy Of Quercus Infectoriamentioning

confidence: 99%

“…The chemical composition of Achillea species has been analyzed in detail and extracts of this plant have been demonstrated to contain a number of pharmacological active ingredients, including alkaloids, such as choline, and flavonoids such as rutin and apigenin. Among these, choline was reported to be the active compound for the pharmacological effects of A. millefolium 9 .…”

Section: In Vitro Efficacy Of Quercus Infectoriamentioning

confidence: 99%

Quercus infectoria Oliv. ve Achillea millefolium L. Ekstrelerinin Blastocystis spp. İzolatlarına in vitro Etkileri

Özbilgin¹,

Durmuşkahya²,

Kilimcioğlu³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryBlastocystis is a common intestinal parasite that can inhabit the intestinal tract of humans and many animals. Despite it was firstly described almost 100 years ago; many subjects are still under debate about Blastocystis, including its life-cycle, pathogenic potential and treatment of infected individuals. Historically, local plant species have been used for therapeutic purposes by the local people of Anatolia. Here, hexane and methanol extracts of two local plants, Quercus infectoria (Fagaceae) and Achillea millefolium, which have been used against diarrhea in Anatolia, were examined for their in vitro efficacies against Blastocystis. LC 50 and EC 50 values of the plant extracts were determined by Brine Shrimp and Graphpad Prism 5® methods, respectively. The results showed that LC 50 (500 µg/ml) and EC 50 (198.8 µg/ml) concentrations of the methanol extract of A. millefolium were lowest compared to other extracts, its anti-Blastocystis activity was found to be comparable to metronidazole and it showed no cytotoxic activity. These initial results suggest that the methanol extract of A. millefolium may be a novel option for the treatment of Blastocystis infections in humans in future, if confirmed by further, larger-scale studies. Keywords: Blastocystis, treatment, Medicinal plants, Quercus infectoria, Achillea millefolium Quercus infectoria Oliv. ve Achillea millefolium L. Ekstrelerinin Blastocystis spp. İzolatlarına in vitro Etkileri ÖzetBlastocystis spp, insanların ve birçok hayvanın gastrointestinal sistemine yerleşen yaygın bir bağırsak parazitidir. Yaklaşık 100 yıl önce tanımlanmış olmasına rağmen, yaşam döngüsü, patojenitesi ve tedavisini içeren birçok konu halen gizemini korumaktadır. Geçmişten bugüne Anadolu'da çok sayıda bitki halk tarafından tedavi amacıyla kullanılmıştır. Bu projede ishale karşı kullanılan bitkilerden ülkemizde yetişen Quercus infectoria (Fagaceae) ve Achillea millefolium'un hekzan ve metanol ile hazırlanan ekstrelerinin in vitro ortamda Blastocystis spp. 'lerin üremesi üzerine etkileri incelenmiştir. Bitki ekstrelerinin LC 50 değeri "Brine Shrimp" yöntemi, EC 50 değeri Graphpad Prism 5® istatistik yöntemi kullanılarak saptanmıştır. Sonuç olarak, A. millefolium'un metanol ekstresinin LC 50 (500 µg/ml) ve EC 50 (198.8 µg/ml) konsantrasyonları diğer ekstrelerle kıyaslandığında en düşük bulunmuş, anti-Blastocystis aktivitesinin ise metronidazol grubunun değerlerine en yakın olduğu ve sitotoksik aktivite göstermediği saptanmıştır. Bu sonuçlar A. millefolium'un metanol ekstresinin, ileride yapılacak geniş kapsamlı çalışmalarla doğrulandığında, Blastocystis spp. enfeksiyonlarının tedavisinde yeni bir seçenek olabileceğini göstermektedir. The present study was financially supported by the

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“…Flavonoids inhibit gastrointestinal motility/contractility and diarrhoea (Di Carlo et al ., ; Gálvez et al ., ; Gharzouli and Holzer, ; Capasso et al ., ; Borrelli et al ., ), attenuate visceral pain (Gadotti et al ., ; Shi et al ., ) and intestinal inflammation (Ocete et al ., ; Park et al ., ), and exert hepatoprotective (Jayaraj et al ., ; Kim et al ., ; Liu et al ., ) and gastric antiulcer actions (Di Carlo et al ., ; Izzo et al ., ; Suzuki et al ., ; Borrelli and Izzo, ; Hariprasath et al ., ). Concerning the gastric antiulcer activity, Awad and colleagues showed that four flavonoids, isolated from Euphorbia cuneata and identified as naringenin, aromadendrin, apigenin and 4'‐O‐methoxy‐luteolin‐7‐O‐rhamnoglucoside, demonstrated antiulcerogenic action in the ethanol model of gastric ulcer (Awaad et al ., ).…”

Section: Introductionmentioning

confidence: 98%

Novel Insights into the Pharmacology of Flavonoids

Romano

Pagano

Montanaro

et al. 2013

Phytotherapy Research

224

137

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Flavonoids are widely distributed secondary metabolites and currently consumed in large amounts in the daily diet. In this article, some of the most recent developments in flavonoid - and related polyphenolic compounds - pharmacology are discussed, with particular emphasis on very recent data, most of which are published in Phytotherapy Research, which highlight new aspects in flavonoid anti-inflammatory, antilipidemic, antihyperglycemic, antiviral, hepatoprotective, gastric antiulcer, cardioprotective, neuroprotective, antioxidant and anticancer actions. These updated data confirm the well-established diverse beneficial pharmacological actions and might support the perspective for a therapeutic use.

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Prokinetic effect of a standardized yarrow (Achillea millefolium) extract and its constituent choline: studies in the mouse and human stomach

Cited by 22 publications

References 34 publications

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

Quercus infectoria Oliv. ve Achillea millefolium L. Ekstrelerinin Blastocystis spp. İzolatlarına in vitro Etkileri

Novel Insights into the Pharmacology of Flavonoids

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