Prokineticin 1 is a novel factor regulating porcine corpus luteum function

Baryla, Monika; Goryszewska-Szczurek, Ewelina; Kaczyński, Piotr; Balboni, Gianfranco; Wacławik, Agnieszka

doi:10.1038/s41598-023-32132-3

Cited by 3 publications

(2 citation statements)

References 45 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, PROK1 acting through PROKR1 is an embryonic signal mediator in the endometrium and participates in early pregnancy establishment by angiogenesis promotion, trophoblast cell proliferation and adhesion, and the regulation of the expression of genes involved in conceptus–maternal communication (Figure 2). Moreover, our recent study suggests that PROK1 can also regulate porcine CL function (Baryla et al, 2021).…”

Section: Embryo Implantation and The Proinflammatory Environment At E...mentioning

confidence: 98%

Novel insights into conceptus–maternal signaling during pregnancy establishment in pigs

Kaczyński

Goryszewska-Szczurek

Baryla

et al. 2022

Molecular Reproduction Devel

View full text Add to dashboard Cite

Pregnancy establishment in mammals, including pigs, requires coordinated communication between developing conceptuses (embryos with associated membranes) and the maternal organism. Porcine conceptuses signalize their presence by secreting multiple factors, of which estradiol‐17β (E2) is considered the major embryonic signal initiating the maternal recognition of pregnancy. During this time, a limited supply of prostaglandin (PGF2α) to the corpora lutea and an increased secretion of luteoprotective factors (e.g., E2 and prostaglandin E2 [PGE2]) lead to the corpus luteum's maintained function of secreting progesterone, which in turn primes the uterus for implantation. Further, embryo implantation is related to establishing an appropriate proinflammatory environment coordinated by the secretion of proinflammatory mediators including cytokines, growth factors, and lipid mediators of both endometrial and conceptus origin. The novel, dual role of PGF2α has been underlined. Recent studies involving high‐throughput technologies and sophisticated experimental models identified a number of novel factors and revealed complex relationships between these factors and those already established. Hence, it seems that early pregnancy should be regarded as a sequence of processes orchestrated by pleiotropic factors that are involved in redundancy and compensatory mechanisms that preserve the essential functions critical for implantation and placenta formation. Therefore, establishing the hierarchy between all molecules present at the embryo–maternal interface is now even more challenging

show abstract

Section: Embryo Implantation and The Proinflammatory Environment At E...mentioning

confidence: 98%

Novel insights into conceptus–maternal signaling during pregnancy establishment in pigs

Kaczyński

Goryszewska-Szczurek

Baryla

et al. 2022

Molecular Reproduction Devel

View full text Add to dashboard Cite

show abstract

“…Moreover, endocrine-gland-derived VEGF (EG-VEGF) is important in the ovarian corpus luteum and tumor [49][50][51]. EG-VEGF signaling regulates VEGFA secretion and angiogenin (ANG) mRNA and protein expression in the corpus luteum.…”

Section: Signaling Pathways 271 Vascular Endothelial Growth Factor (V...mentioning

confidence: 99%

Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumors

Min,

Lee,

Lee

2024

Animals

View full text Add to dashboard Cite

The corpus luteum is a temporary endocrine gland formed in the ovary after ovulation, and it plays a critical role in animal reproductive processes. Tumors rely on the development of an adequate blood supply to ensure the delivery of nutrients and oxygen and the removal of waste products. While angiogenesis occurs in various physiological and pathological contexts, the corpus luteum and tumors share similarities in terms of the signaling pathways that promote angiogenesis. In the corpus luteum and tumors, apoptosis plays a crucial role in controlling cell numbers and ensuring proper tissue development and function. Interestingly, there are similarities between the apoptotic-regulated signaling pathways involved in apoptosis in the corpus luteum and tumors. However, the regulation of apoptosis in both can differ due to their distinct physiological and pathological characteristics. Thus, we reviewed the biological events of the corpus luteum and tumors in similar microenvironments of angiogenesis and apoptosis.

show abstract

Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumor for Approaching the Novel Research Animal Model

Min,

Lee,

Lee

2024

Preprint

View full text Add to dashboard Cite

The corpus luteum is a temporary endocrine gland formed in the ovary after ovulation, and it plays a critical role in reproductive processes. Tumors rely on the development of an adequate blood supply to ensure the delivery of nutrients and oxygen and the removal of waste products. While angiogenesis occurs in various physiological and pathological contexts, the corpus luteum and tumors share similarities in the signaling pathways that promote angiogenesis. In the corpus luteum and tumors, apoptosis plays a crucial role in controlling cell numbers and ensuring proper tissue development and function. Interestingly, there are similarities in the apoptotic-regulated signaling pathways involved in apoptosis between the corpus luteum and tumors. However, the regulation of apoptosis can differ due to their distinct physiological and pathological characteristics. Thus, we reviewed the biological events of the corpus luteum and tumors in similar microenvironments of angiogenesis and apoptosis for studying novel research methods.

show abstract

Prokineticin 1 is a novel factor regulating porcine corpus luteum function

Cited by 3 publications

References 45 publications

Novel insights into conceptus–maternal signaling during pregnancy establishment in pigs

Novel insights into conceptus–maternal signaling during pregnancy establishment in pigs

Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumors

Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumor for Approaching the Novel Research Animal Model

Contact Info

Product

Resources

About