Prolactin an diabetogenic hormone?

Blüher, M.; Wallaschofski, Henri

doi:10.1055/s-2005-862886

Cited by 1 publication

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“…Its dysfunction potentially links obesity to its associated metabolic disorders. [ 2 ] Three types of adipose tissue have been identified in mammals, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue. [ 3 ] White adipocytes are in charge of energy storage in the form of lipid droplets, while brown adipocytes transform lipid droplets into heat in mitochondria via uncoupling protein 1 (Ucp1).…”

Section: Introductionmentioning

confidence: 99%

Trim21 Regulates the Postnatal Development and Thermogenesis of Brown Adipose Tissue

Hu,

Xu,

Xiao

et al. 2023

Advanced Biology

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Brown adipose tissue undergoes rapid postnatal development to mature and plays a crucial role in thermoregulation and energy expenditure, which protects against cold and obesity. Herein, it is shown that the expression of Trim21 mRNA level of interscapular brown adipose tissue elevates after birth, and peaks at P14 (postnatal day 14). Trim21 depletion severely impairs the maturation of interscapular brown adipose tissue, decreases the expression of a series of thermogenic genes, and reduces energy expenditure. Consistently, the loss of Trim21 also leads to a suppression of white adipose tissue “browning”, in response to cold exposure and a β‐adrenergic agonist, CL316,243. In addition, Trim21−/− mice are more prone to high‐fat diet‐induced obesity compared with the control littermates. Taken together, the study for the first time reveals a critical role of Trim21 in regulating iBAT postnatal development and thermogenesis.

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Section: Introductionmentioning

confidence: 99%