Prolactin and Migraine: Effect of L‐Dopa on Plasma Prolactin Levels in Migraineurs and Normals

Nattero, G; Corno, M.; Savi, L; Isaia, Giovanni Carlo; Priolo, Claudio; Mussetta, M.

doi:10.1111/j.1526-4610.1986.hed2601009.x

Cited by 19 publications

(16 citation statements)

References 8 publications

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“…Some authors have suggested hypersensitivity of dopamine receptors based on the observation that migraineurs showed higher PRL after taking dopaminergic agents [6][7][8][9]. Reduced responsiveness of pituitary lactotroph cells to the effect of dopaminergic agents has also been postulated on the basis of a less marked inhibition of PRL secretion to Ldopa in migraine [10]. It is difficult to explain our result, or similar ones reported in the literature, by using this hypothesis.…”

Section: Discussioncontrasting

confidence: 56%

“…Some authors suggest a hypersensitivity of dopamine receptors based on the observation that migraineurs showed higher PRL after taking dopaminergic agents [6][7][8][9]. Reduced responsiveness of pituitary lactotroph cells to the action of dopaminergic agents has also been postulated [10]. In 1989, Awaki et al [11] actually suggested a serotoninergic hyperfunction rather than a dopaminergic dysfunction.…”

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confidence: 99%

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High prolactin levels as a worsening factor for migraine

et al. 2006

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IntroductionMigraine is a very complex condition; in fact its physiopathology is not completely clear [1]. It is believed that many neurotransmitters are implicated in this process [2], and hormones have been shown to play a major role in women [3]. Among the neuroendocrinological alterations, disorders of the hypothalamic-hypophysial axis are believed to be implicated in the pathogenesis of primary J Headache Pain (2006) 7:83-89 DOI 10.1007 High prolactin levels as a worsening factor for migraine

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Section: Discussioncontrasting

confidence: 56%

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confidence: 99%

High prolactin levels as a worsening factor for migraine

et al. 2006

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“…A variety of headache phenotypes has been associated with pituitary tumors [6–9]. Some authors suggest a hypersensitivity of dopamine receptors, based on the observation that, some headaches showed higher prolactin (PRL) after taking dopaminergic agents [10]. Other authors suggested a serotoninergic hyperfunction rather than dopaminergic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma

et al. 2008

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The pathophysiology of pituitary-associated headache is unknown, although structural and functional features of the tumour are proposed mechanisms. The objective of this study was to evaluate whether headache in a population with pituitary micro-adenomas was related to hyperprolactinemia. We recruited 29 patients with microprolactinoma and headache: 16 with migraine (group A) and 13 with tension-type-headache (group B). The prolactin (PRL) levels measured during attacks of headache were significantly higher in nine patients (56%) of group A and in one patient (8%) of group B. In four of the nine patients of group A, PRL increased after thyrotropin-releasing-hormone (TRH) test and induced severe attacks. After dopamine-agonist (DA) treatment, the headache improved in seven (44%) patients of the group A and in two (15%) patients of the group B. Three of the four patients in whom the TRH-test induced headache attacks, improved after DA treatment. We suggest that hyperprolactinemia may contribute to development of pain in migraine subgroups and further TRH-test could be used to predict which patients could benefit by DA therapy.

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“…Some authors suggest a hypersensitivity of dopamine receptors based on the observation that some headaches showed higher PRL after taking dopaminergic agents [8]. Reduced responsiveness of pituitary lactotroph cells to the action of dopaminergic agents has also been postulated [9]. Other authors suggested a serotoninergic hyperfunction rather than dopaminergic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

SUNCT and high nocturnal prolactin levels: some new unusual characteristics

et al. 2007

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SUNCT is a rare condition characterised by a short-lasting periorbital pain associated with autonomic symptoms and is usually unresponsive to pharmacological treatment. We report a case of SUNCT syndrome linked to a pituitary micro-adenoma, with only nocturnal attacks. The nocturnal levels of prolactin (PRL) were increased, while other hormonal, haematological, serological and biochemical investigations and levels of PRL did not reveal abnormal findings during the day-time. PRL serum secretion after thyrotropin-releasing hormone test was lower than nocturnal secretion, but not enough to induce severe attacks. We suggest that in our patient the rise of nocturnal levels of PRL could have a direct role in the worsening of this headache, perhaps secondarily to an altered regulation of the hypothalamic-hypophysial axis, however the actual influence of sleep and the interaction between all neurotransmitters and hormones needs to be clarified further.

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Prolactin and Migraine: Effect of L‐Dopa on Plasma Prolactin Levels in Migraineurs and Normals

Cited by 19 publications

References 8 publications

High prolactin levels as a worsening factor for migraine

High prolactin levels as a worsening factor for migraine

Relationship between high prolactine levels and migraine attacks in patients with microprolactinoma

SUNCT and high nocturnal prolactin levels: some new unusual characteristics

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