Prolactin and polyamine catabolism: specific effect on polyamine oxidase activity in rat thymus

Ferioli, Maria Elena; Pirona, Lorenza; Pinotti, Orietta

doi:10.1016/s0303-7207(00)00264-1

Cited by 22 publications

(16 citation statements)

References 45 publications

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“…In the normal thymocytes used in the present investigation, the induction of apoptosis after etoposide treatment was paralleled by the decrease in total polyamine content and an increase in the activity of PAO which is consistent with previous observations suggesting a direct role of PAO in apoptosis induction [5,14]; our results also confirm that this enzyme is inducible also in thymocytes during apoptosis, as already shown by us [22,23,30] and others [4,14,40,41] for other cell systems, both in vivo and in vitro. Despite the lack of conclusive evidence about their role(s) in cell proliferation and apoptosis, polyamines have been taken as suitable targets for therapies which are specifically addressed to alter the cell cycle or induce cell death [3,5,7,19,20].…”

Section: Discussionsupporting

confidence: 93%

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Administration of the antitumor drug mitoguazone protects normal thymocytes against spontaneous and etoposide-induced apoptosis

Ferioli¹,

Bottone

Soldani

et al. 2004

CMLS, Cell. Mol. Life Sci.

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The suggestion has been made that polyamines may be involved in the control of cell death, since exceedingly high or low levels induce apoptosis in different cell systems. For a deeper insight into the relationship between apoptosis and polyamine metabolism, we investigated in vitro the effect on rat thymocytes of mitoguazone (MGBG, which inhibits S-adenosylmethionine decarboxylase, i.e. a key enzyme in the polyamine biosynthetic pathway). Thymocytes were selected as an especially suitable model system, since they undergo spontaneous apoptosis in vivo and can be easily induced to apoptose in vitro by etoposide, used here as an apoptogenic agent. MGBG protected thymocytes from both spontaneous and drug-induced apoptosis, and this protective effect was associated with a decrease in polyamine oxidase activity and total polyamine levels.

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Section: Discussionsupporting

confidence: 93%

“…8]. In addition, our previous studies showed a positive correlation between PAO activity and apoptosis in rat thymus after hormonal treatments [22,23]. Mitoguazone (MGBG) is a guanidino-containing compound, structurally similar to spermidine, which exerts an inhibiting action on S-adenosylmethionine decarboxylase, i.e.…”

mentioning

confidence: 99%

Administration of the antitumor drug mitoguazone protects normal thymocytes against spontaneous and etoposide-induced apoptosis

Ferioli¹,

Bottone

Soldani

et al. 2004

CMLS, Cell. Mol. Life Sci.

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“…Polyamines Putrescine (Put), spermidine (Spd), and spermine (Spm) form a group of aliphatic amines known as polyamines (Pinto and Ferreira, 2015). Polyamines have been shown to be involved in the differentiation of immune cells and the regulation of the inflammatory response (Ferioli et al, 2000;Moinard et al, 2005;Larqué et al, 2007). In addition, there is evidence that high polyamine intake in children is significantly correlated with preventing food allergies (Dandrifosse et al, 2000).…”

Section: Carbohydratementioning

confidence: 99%

Application of metabolomics to assess the impact of Cu(OH)2 nanopesticide on the nutritional value of lettuce (Lactuca sativa): Enhanced Cu intake and reduced antioxidants

et al. 2016

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Copper-based nanopesticides are increasingly being used in the agriculture, especially in organic farming. This has triggered some concerns about their risk to environmental and human health. In this study, 24-day-old lettuce plants grown in soil were exposed via the leaves to different concentrations (0, 1050 and 1555 mg/L) of Cu(OH) 2 nanopesticides for one month. Results showed Cu was mainly localized in lettuce leaves (823-1111 and 1353-2008 mg/kg in vascular and photosynthetic tissues), which may potentially increase Cu intake and impact human health. In addition, foliar application of Cu(OH)2 nanopesticide significantly increased potassium concentration in lettuce leaves by 6-7% and 21-28%, in vascular and photosynthetic tissues. A Gas Chromatography-Time-of-Flight Mass Spectrometry (GC-TOF-MS) based metabolomics approach was applied to determine hundreds of organic compounds simultaneously. Using relative quantitation and Partial Least Squares-Discriminant Analysis (PLS-DA) clustering of all compounds, clear differences were observed in the metabolite profiles of control and Cu(OH) 2 nanopesticides treated leaves. Discriminating compounds include amino acids, organic acids, polyamines, vitamin C and polyphenols. Dehydroascorbic acid and cis-caffeic acid, which are important antioxidants, were significantly decreased (19-33% and 5-8%) due to foliar exposure to the nanopesticide. Total antioxidant capacity was significantly decreased 20-23% after exposure to Cu(OH) 2 nanopesticides. There was also up-and down-regulation of a number of amino acids, particularly 4-hydroxybutytic acid (GABA) which decreased 50% compared to the control, potentially affecting the overall nutritional value of lettuce leaves exposed to the Cu(OH) 2 nanopesticides. In future work, determining an appropriate level of nanopesticide will be important to obtain the antifungal benefits without resulting in a significant decrease in nutritional value.

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“…Among other compounds detected in human milk, polyamines, such as spermidine, spermine and putrescine, are of great interest due to their reported biological roles in eukaryotic cells, stimulating cellular proliferation and differentiation [5]. Moreover, there is evidence that polyamines participate in several processes related to the immune system, including immune system development [6,7], inflammatory response modulation [8,9] and normal function of the immune system [10]. Polyamines may also have a potential role in the growth and development of the digestive tract wall and colonic mucosa in neonatal mammals [11].…”

Section: Introductionmentioning

confidence: 99%

Infant formula supplemented with polyamines alters the intestinal microbiota in neonatal BALB/cOlaHsd mice

Gómez-Gallego

Collado

Ilo

et al. 2012

The Journal of Nutritional Biochemistry

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Prolactin and polyamine catabolism: specific effect on polyamine oxidase activity in rat thymus

Cited by 22 publications

References 45 publications

Administration of the antitumor drug mitoguazone protects normal thymocytes against spontaneous and etoposide-induced apoptosis

Administration of the antitumor drug mitoguazone protects normal thymocytes against spontaneous and etoposide-induced apoptosis

Application of metabolomics to assess the impact of Cu(OH)2 nanopesticide on the nutritional value of lettuce (Lactuca sativa): Enhanced Cu intake and reduced antioxidants

Infant formula supplemented with polyamines alters the intestinal microbiota in neonatal BALB/cOlaHsd mice

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