“…Discussing the contribution of PRL (in general terms) in pregnancy is not simple, as there is maternal PRL in circulation predominantly secreted by the maternal pituitary, placental PRL with mostly paracrine action, and fetal PRL as well. 8 To make it even more complex, the placenta is also able to generate PRL remnants by upregulating local metalloproteinases. 9 PRL that is secreted by (early) placental tissue is assumed to exert an important role in the early development of fetal-maternal interface.…”