Prolactin

Vonderhaar, Barbara K.

doi:10.1007/978-1-4899-5043-7_12

Cited by 24 publications

(1 citation statement)

References 315 publications

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“…Alveolar proliferation and the induction of terminal differentiation, as indicated by the transcriptional activation of milk protein genes, require the presence of prolactin (20,28,33,34). In the functional postpartum gland high levels of activated Stat5 can be found while only small amounts of phosphorylated Stat1 and Stat3 have been detected (35).…”

Section: Mammopoiesis and Lactogenesismentioning

confidence: 99%

Prolactin Signaling in Mammary Gland Development

Hennighausen

Robinson

Wagner

et al. 1997

Journal of Biological Chemistry

164

107

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Section: Mammopoiesis and Lactogenesismentioning

confidence: 99%

Prolactin Signaling in Mammary Gland Development

Hennighausen

Robinson

Wagner

et al. 1997

Journal of Biological Chemistry

164

107

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Cellular expression of growth hormone and prolactin receptors in human breast disorders

et al. 1998

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Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland

Hovey

Trott

Ginsburg

et al. 2001

Developmental Dynamics

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Ductal branching within the mammary gland is stimulated by prolactin (PRL) and progesterone (P) acting through their receptors (PRLR and PR). Analysis of mammary gland PRLR expression revealed increasing expression of the long form (L-PRLR) and two of the three short forms (S1-and S3-PRLR) during puberty that became maximal late in pubescence and early gestation, then declined during gestation. By contrast, S2-PRLR mRNA levels remained constant. Examination of stromal PRLR revealed the consistent expression of L-PRLR mRNA. By contrast, S1-PRLR was present only in the mammary fat pad of neonates, whereas high neonatal expression of S2-PRLR became undetectable during puberty. Stromal expression of S3-PRLR decreased to low levels during puberty and was undetectable during lactation and involution. Exogenous PRL stimulated DNA synthesis in both epithelial and adjacent stromal cells in vivo. Distribution of PRLR mRNA in mammary epithelium was homogeneous before puberty and heterogeneous during puberty, gestation, and early lactation. A mutual role for PRLR and PR was suggested wherein PR mRNA increased beyond 6 weeks to maximal levels during puberty and gestation then became undetectable during lactation. In situ hybridization revealed that PR mRNA distribution is homogeneous in the ductal epithelium before 6 weeks and heterogenous during puberty and gestation and that PRLR and PR are similarly distributed in the ductal epithelium. Neither hormone stimulated DNA synthesis in mammary glands of ovariectomized females while their effects interacted markedly. These results demonstrate differential PRLR transcription by epithelial and stromal cells and a similar distribution of PRLR and PR that may facilitate the interaction between P and PRL during ductal branching in the mammary gland. Published 2001 Wiley-Liss, Inc. †

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Prolactin

Cited by 24 publications

References 315 publications

Prolactin Signaling in Mammary Gland Development

Prolactin Signaling in Mammary Gland Development

Cellular expression of growth hormone and prolactin receptors in human breast disorders

Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland

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