Prolactin receptor in human endometriotic tissues

Martínez, Luisa Bermejo; Leyva, Manuel; Romero, Ivone Castro

doi:10.1034/j.1600-0412.2002.810102.x

Cited by 14 publications

(5 citation statements)

References 39 publications

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“…We found very strong LD across the PR locus. Serum prolactin levels have been implicated as a cause for infertility in patients with minimal to mild endometriosis (Gregoriou et al, 1999;Martinez et al, 2002). The promoter SNP rs10895068 was associated with prolactin levels in a population sample (Westberg et al, 2004); although this SNP did not show individual association with endometriosis in our families, or in the subset with minimal-mild endometriosis and subfertility, it may warrant further investigation.…”

Section: Discussionmentioning

confidence: 65%

Association between polymorphisms in the progesterone receptor gene and endometriosis

Treloar

Zhao

Armitage

et al. 2005

MHR: Basic Science of Reproductive Medicine

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The progesterone receptor (PR) is a candidate gene for the development of endometriosis, a complex disease with strong hormonal features, common in women of reproductive age. We typed the 306 base pair Alu insertion (AluIns) polymorphism in intron G of PR in 101 individuals, estimated linkage disequilibrium (LD) between five single-nucleotide polymorphisms (SNPs) across the PR locus in 980 Australian triads (endometriosis case and two parents) and used transmission disequilibrium testing (TDT) for association with endometriosis. The five SNPs showed strong pairwise LD, and the AluIns was highly correlated with proximal SNPs rs1042839 (delta2 = 0.877, D9 = 1.00, P < 0.0001) and rs500760 (delta2 = 0.438, D9 = 0.942, P < 0.0001). TDT showed weak evidence of allelic association between endometriosis and rs500760 (P = 0.027) but not in the expected direction. We identified a common susceptibility haplotype GGGCA across the five SNPs (P = 0.0167) in the whole sample, but likelihood ratio testing of haplotype transmission and non-transmission of the AluIns and flanking SNPs showed no significant pattern. Further, analysis of our results pooled with those from two previous studies suggested that neither the T2 allele of the AluIns nor the T1/T2 genotype was associated with endometriosis.

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Section: Discussionmentioning

confidence: 65%

Association between polymorphisms in the progesterone receptor gene and endometriosis

Treloar

Zhao

Armitage

et al. 2005

MHR: Basic Science of Reproductive Medicine

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“…Although some antibodies targeting PRLR have been shown to reduce tumor malignancy by blocking autocrine/endocrine PRL activ-ities (6,7), the full-length PRLR gene product was not detected in endometriosis tissues (8). Our results from screening an array of human uterine cancer cells indicated that transcriptionally spliced isoforms of PRLR products might be responsible for mediating activities of the tumoral PRL/PRLR axis.…”

Section: Introductionmentioning

confidence: 66%

Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer

Wen

Wang

Chelariu-Raicu

et al. 2020

Molecular Cancer Therapeutics

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◥Abnormal activity of human prolactin (PRL) and its membrane-associated receptor (PRLR) contributes to the progression of uterine carcinoma. However, the underlying mechanisms are not well understood, and current means of targeting the PRL/PRLR axis in uterine cancer are limited. Our integrated analyses using The Cancer Genome Atlas and Genotype-Tissue Expression (GTEx) databases demonstrated that a short form of PRLR (PRLR_SF) is the isoform predominantly expressed in human uterine cancers; expression of this PRLR_SF was elevated in uterine cancers in comparison with cancer-free uterine tissues. We hypothesized that the overexpression of PRLR_SF in uterine cancer cells contributes, in part, to the oncogenic activity of the PRL/PRLR axis. Next, we employed G129R, an antagonist of human PRL, to block the PRL/PRLR axis in both PTEN wt and PTEN mut orthotopic mouse models of uterine cancer. In comparison with control groups, treatment with G129R as monotherapy or in combination with paclitaxel resulted in a significant reduction of growth and progression of orthotopic uterine tumors. Results from protein profiling of uterine cancer cells and in vivo tumors revealed a set of new downstream targets for G129R. Our results showed that G129R induced sub-G 0 population arrest, decreased nascent protein synthesis, and initiated FOXO3a/EIF-4EBP1-mediated cell death in both PTEN wt and PTEN mut uterine cancer cells. Collectively, our results show a unique pattern of PRLR_SF expression predominantly in uterine cancer. Moreover, FOXO3a and EIF-4EBP1 are important mediators of cell death following G129R treatment in uterine cancer models.

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“…Both PRL-R and GH hormones are known to contribute to this process through their autocrine/paracrine actions. Additionally, IGF1 and IGF2, which are downstream targets, are involved in regulating cellular growth and differentiation (69). The significance of prolactin family members in uterine development and endometrial adenogenesis has been well established (70).…”

Section: Role Of Adenogenesis In Endometriosismentioning

confidence: 99%

Pathogenesis of Endometriosis: Focus on Adenogenesis-related Factors

SIGNORILE,

BALDI,

VICECONTE

et al. 2023

In Vivo

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Endometriosis can be defined as the presence of the endometrium outside the uterine cavity. It affects approximately 10% of women of reproductive age and causes infertility, chronic pain, and deterioration of the quality of life. Since the identification of the disease, various pathogenetic mechanisms have been proposed, such as retrograde menstruation, coelomic metaplasia, hormonal imbalance, stem cell involvement, and alterations in epigenetic regulation. However, the underlying pathogenesis of endometriosis remains inadequately understood. Elucidation of the precise mechanism of the development and progression of endometriosis is crucial for effective treatment. This review presents the major pathogenetic theories of endometriosis based on current research studies with a major focus on the potential role of uterine factors.

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Prolactin receptor in human endometriotic tissues

Cited by 14 publications

References 39 publications

Association between polymorphisms in the progesterone receptor gene and endometriosis

Association between polymorphisms in the progesterone receptor gene and endometriosis

Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer

Pathogenesis of Endometriosis: Focus on Adenogenesis-related Factors

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