Prolactin Secretion and Sleep

Spiegel, Karine; Follénius, M.; Simon, Chantal; Saini, J.; Ehrhart, J; Brandenberger, G.

doi:10.1093/sleep/17.1.20

Cited by 81 publications

(32 citation statements)

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“…The nadir is found at midday. Prolactin elevation has also been shown in afternoon naps, thus confirming the homeostatic effect of sleep itself, regardless of the time of day (Spiegel et al, 1994). Nevertheless, there are also weak circadian effects, as shown in studies of phase-advance and delay.…”

Section: Prolactin Axismentioning

confidence: 54%

Neurohormones and Sleep

Frénette¹,

Guilleminault²

2009

CONTINUUM: Lifelong Learning in Neurology

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Mutual interactions between neurohormones and sleep have been extensively studied since the pioneering work done in the 1960s on growth hormone secretion. Hormonal secretion pattern is either influenced predominantly by sleep, independently of circadian timing, or more closely coupled to the light-dark cycle, although both processes ultimately interact with one another. Individual differences regarding gender and age are sometimes prominent, so careful selection of groups to be studied is important. Because of such fragmented data, generalizations can seldom be derived from the available literature. Much like puzzle pieces, every bit of information constitutes but one small component of the broader, more global, neurohormonal picture seen in sleep. We have divided this analysis into discussions of the adenohypophysis, neurohypophysis, and pineal gland, describing the reciprocal influence regarding sleep and the different neurohormones. Specific issues related to gender differences and selected endocrinologic diseases will also be addressed, as well as changes related to the most common sleep disorder, obstructive sleep apnea.Continuum Lifelong Learning Neurol 2009;15(2):108-124.

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Section: Prolactin Axismentioning

confidence: 54%

Neurohormones and Sleep

Frénette¹,

Guilleminault²

2009

CONTINUUM: Lifelong Learning in Neurology

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“…However, in a subsequent study, absolute sleep duration was not related to estradiol levels although greater variation in sleep duration was significantly correlated [73]. Another hormone active in reproductive physiology, prolactin, is well known to be augmented by sleep, largely independent of circadian timing [107,114].…”

Section: Sleep Influences Reproductive Hormonesmentioning

confidence: 82%

Sleep, Circadian Rhythms, and Fertility

Goldstein

Smith

2016

Curr Sleep Medicine Rep

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Adequate sleep is crucial for general health and wellbeing. Although the neuronal control of the reproductive axis and sleep-generating neurons share an anatomical location, little is known regarding the impact of sleep and circadian disruption on fertility in women. Animal models have established clear circadian control of the pre-ovulatory luteinizing hormone surge. Additionally, disruption of the circadian timing system by exposure to abnormal light-dark cycles or mutations of core clock genes results in diminished reproductive capacity in animals. Abnormalities in menstruation, fertility, and early pregnancy maintenance in female shift workers provide evidence for a role of circadian rhythms in the reproductive health of women. Reproductive hormones may modify sleep, and the relationship is bidirectional such that sleep disruption may alter the profile of reproductive hormone secretion. Therefore, sleep, apart from its circadian timing, may also have relevance in attaining pregnancy. Additionally, infertility is associated with psychological distress which may result in poor quality sleep. The interaction between psychological distress and disturbed sleep in reproduction has garnered minimal attention and may be a crucial factor to consider during the evaluation and treatment of infertility. This work reviews animal models and evidence in women that suggest a role for sleep and circadian rhythms in reproductive health and reveals areas that require future investigation.

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“…Men displayed a circadian rhythm in prolactin levels, with a nadir in the late biological morning/early afternoon, and high levels during the late biological afternoon, evening and night (50). Using two 24-h experiments in healthy young men, one with normal night sleep and one with delayed sleep, Spiegel et al (51) demonstrated that sleep onset was rapidly followed by an increase in prolactin secretion, and awakenings coincided with an immediate offset of this active secretion (within the first 10 min). Prolactin secretion was pulsatile, as reflected by pulses in plasma concentrations but with a phase advance averaging 10-20 min (51,52).…”

Section: Discussionmentioning

confidence: 99%

“…Plasma concentrations and secretory rates of prolactin have generally been reported to decrease at the onset of REM sleep episodes and to increase with slow wave activity (51,52). In the present study, even if blood was only sampled at two time points in the day, the significant time of day effect for prolactin concentration may reflect its circadian phase.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery

Arnal

Drogou

Sauvet

et al. 2016

J Neuroendocrinology

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Total sleep deprivation (TSD) in humans is associated with altered hormonal levels, which may have clinical relevance. Less is known about the effect of an extended sleep period before TSD on these hormonal changes. Fourteen subjects participated in two experimental counterbalanced conditions (randomised cross-over design): extended sleep (21.00-07.00 h time in bed, EXT) and habitual sleep (22.30-07.00 h time in bed, HAB). For each condition, subjects performed two consecutive phases: six nights of either EXT or HAB. These nights were followed by 3 days in the sleep laboratory with blood sampling at 07.00 and 17.00 h at baseline (B-07.00 and B-17.00), after 24 and 34 h of continuous awakening (24 h-CA, 34 h-CA) and after one night of recovery sleep (R-07.00 and R-17.00) to assess testosterone, cortisol, prolactin and catecholamines concentrations. At 24 h of awakening, testosterone, cortisol and prolactin concentrations were significantly lower compared to B-07.00 and recovered basal levels after recovery sleep at R-07.00 (P < 0.001 for all). However, no change was observed at 34 h of awakening compared to B-17.00. No effect of sleep extension was observed on testosterone, cortisol and catecholamines concentrations at 24 and 34 h of awakening. However, prolactin concentration was significantly lower in EXT at B-07.00 and R-07.00 compared to HAB (P < 0.05, P < 0.001, respectively). In conclusion, 24 h of awakening inhibited gonadal and adrenal responses in healthy young subjects and this was not observed at 34 h of awakening. Six nights of sleep extension is not sufficient to limit decreased concentrations of testosterone and cortisol at 24 h of awakening but may have an impact on prolactin concentration.

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Prolactin Secretion and Sleep

Cited by 81 publications

References 0 publications

Neurohormones and Sleep

Neurohormones and Sleep

Sleep, Circadian Rhythms, and Fertility

Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery

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