Proliferating cell nuclear antigen (PCNA); prognostic value in the clinical recurrence of primary basal cell carcinoma

Tóth, Dénes

doi:10.1016/0923-1811(95)00417-3

Cited by 14 publications

(16 citation statements)

References 9 publications

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“…While ODC expression has not been assessed in the multiple BCCs in NBCCS patients (27), it seems highly likely that these lesions will manifest increased expression of this enzyme. A corollary to this hypothesis is that the epithelial lining of odontogenic keratinocysts in NBCCS patients has enhanced growth potential demonstrated by high expression of known proliferation markers such as PCNA and Ki67 (53)(54)(55)(56)(57)(58).…”

Section: Discussionmentioning

confidence: 99%

Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

Tang¹,

Kim²,

Feith³

et al. 2004

J. Clin. Invest.

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Solar ultraviolet B (UVB) radiation induces cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to tumorigenesis. Therefore ODC is a potentially important target for chemoprevention of basal cell carcinomas (BCCs), the majority of which have mutations in the tumor-suppressor gene known as patched (PTCH). To assess this possibility, we first overexpressed ODC in the skin of Ptch1 +/-mice using a keratin 6 (K6) promoter that directs constitutive ODC expression in the outer root sheath of the hair follicle. UVB irradiation of these mice accelerated induction of BCCs as compared with their Ptch1 +/-littermates. To further verify the role of ODC in BCC tumorigenesis, we used an antizyme (AZ) approach to inhibit ODC activity in the Ptch1 +/-mice. Ptch1 +/-mice with AZ overexpression driven by the K6 promoter were resistant to the induction of BCCs by UVB. Furthermore, oral administration of the suicidal ODC inhibitor α α-difluoromethylornithine reduced UVB-induced BCCs in Ptch1 +/-mice. These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations.Nonstandard abbreviations used: basal cell carcinoma (BCC); α-difluoromethylornithine (DFMO); keratin 5 (K5); nevoid basal cell carcinoma syndrome (NBCCS); ornithine decarboxylase (ODC); antizyme (AZ); outer root sheath (ORS); patched (Ptch); sonic hedgehog (SHH); squamous cell carcinoma (SCC); ultraviolet B (UVB).

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Section: Discussionmentioning

confidence: 99%

Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

Tang¹,

Kim²,

Feith³

et al. 2004

J. Clin. Invest.

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“…EMT had been implicated as the key step in the progression of tumors toward metastasis and invasion (21,26,31). Cancer cells undergoing EMT lost proper target recognition and avoided apoptosis (26).…”

Section: Discussionmentioning

confidence: 99%

“…The ability of a cancer cell to undergo mobility and migration allowed it to change position within the tissues; this process allows cancer cells to leave from primary tumor (21). To investigate the effects of PIK3R3 on cell mobility and migration, we seeded HT-29 or SW48 cells in modified Boyden chambers and assessed cell migration 48 hours later.…”

Section: Pik3r3 Enhances Colorectal Cancer Cell Mobility Migration mentioning

confidence: 99%

“…21). In cancer, cell invasion allows neoplastic cells to enter lymphatic and blood vessels for dissemination into the circulation and then undergo metastatic growth in distant organs (24,25).…”

Section: Pik3r3 Enhances Colorectal Cancer Cell Mobility Migration mentioning

confidence: 99%

“…EMT is a cellular and molecular process, whereby epithelial cells acquire mesenchymal, fibroblastlike properties and demonstrate reduced intercellular adhesion, increased cell motility, and invasion (21,22).…”

Section: Introductionmentioning

confidence: 99%

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PIK3R3 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Colorectal Cancer

Wang

et al. 2014

Molecular Cancer Therapeutics

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Class IA PI3K plays an essential role in the invasion and metastasis of cancer. However, the mechanisms and specific functions of PI3K isoforms in tumor invasion and metastasis are not fully understood. We evaluated the role of PIK3R3, a PI3K regulatory subunit encoded by the PIK3R3 gene, in colorectal cancer invasion and metastasis. Clinical specimens and cell lines data show that the expression level of PIK3R3 is associated with colorectal cancer metastasis. Overexpression of PIK3R3 increases tumor migration and invasion in vitro and promotes metastasis of colorectal cancers in vivo. Furthermore, we investigated that the overexpression of PIK3R3 depends on SNAI2, inducing significant epithelial-to-mesenchymal transition (EMT). Downregulation of PIK3R3 reverses this process, which possibly contributes to the enhanced invasive and metastasizing abilities of colorectal cancer cells. In this study, we found that PIK3R3 plays an important role in colorectal cancer metastasis and might be a potential and specific target for therapies against metastatic colorectal cancer.

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Immunology and growth characteristics of ocular basal cell carcinoma

Rohrbach

Stiemer

Mayer

et al. 2001

Graefe's Arch Clin Exp Ophthalmol

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CD4+ T cells seem to be the most important cell population for BCC immunosurveillance, offering the chance for conservative interferon therapy. The role of CD68+ and HECA-452+ cells has to be further elucidated. In many tumours the large amount of proliferating cells contrasts to the usually slow growth of BCCs, indicating strong apoptotic processes. The results can be regarded only as semiquantitative. So far, ocular and nonocular BCCs exhibit no essential differences regarding immunocompetent cell infiltration and growth characteristics. According to this, palpebral BCCs are "normal" BCCs and not a special BCC variant. Therefore, results from dermatological research concerning BCC can be extended without limitations to their counterparts in the lid area.

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Proliferating cell nuclear antigen (PCNA); prognostic value in the clinical recurrence of primary basal cell carcinoma

Cited by 14 publications

References 9 publications

Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

PIK3R3 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Colorectal Cancer

Immunology and growth characteristics of ocular basal cell carcinoma

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