Proliferating cell nuclear antigen (PCNA): ringmaster of the genome

Paunesku, Tatjana; Mittal, Shilpi; Protić, Miroslava; Oryhon, J.; Korolev, Sergey; Joachimiak, Andrzej; Woloschak, Gayle E.

doi:10.1080/09553000110069335

Cited by 300 publications

(226 citation statements)

References 123 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…It has been reported that analysis of PCNA protein expression could play an important role in the prediction of long term survival and prognosis of patients. PCNA has been reported as the ring master of the genome due to active participation in several molecular pathways responsible for the survival and death of mammalian cells (Paunesku et al, 2001). Overexpression of PCNA has been reported in several cancers including oral cancer (Manojprabhakar et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Singh

Manoharan²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Singh

Manoharan²,

Vasudevan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…33,34 Furthermore, upregulation of PCNA in Reh cells may enhance DNA replication but was probably a result of IR induced DNA repair in our study. 35 Temporal expression profiles may give information about the onset of gene regulation in relation to when the phenotypic changes are detected. Cell cycle arrest was detectable earlier than 4 hr after IR, whereas more than 10 hr were required before significant apoptosis was seen.…”

Section: Discussionmentioning

confidence: 99%

Response of malignant B lymphocytes to ionizing radiation: Gene expression and genotype

Lyng

Landsverk

Kristiansen

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

The human malignant B-lymphocyte cell lines Reh and U698 show arrest in G 2 phase after ionizing radiation (IR), but only Reh cells arrest in G 1 phase and die by apoptosis. We have used cDNA microarrays to measure changes in gene expression at 2, 4 and 6 hr after irradiation of Reh and U698 cells with 0.5 and 4 Gy in order to begin exploring the molecular mechanisms underlying the phenotypic changes. We also investigated whether gene expression changes could be caused by possible aberrations of genes, as measured by comparative genomic hybridization. Reh cells showed upregulation of CDKN1A that likely mediated the G 1 arrest. In contrast, U698 cells have impaired function of TP53 protein and no activation of CDKN1A, suppressing the arrest in G 1 . The G 2 arrest in both cell lines was likely due to repression of PLK1 and/or CCNF. IR-induced apoptosis in Reh cells was probably mediated by TP53 and CDKN1A, whereas a high expression level of MCL1, caused by gene amplification, and activation of the NFKB pathway may have suppressed the apoptotic response in U698 cells. Genes suggested to be involved in apoptosis were activated long before this phenotype was detectable and showed the same temporal expression profiles as genes involved in cell cycle arrest. Our results suggest that differences in functionality and/or copy number of several genes involved in IR-regulated pathways contributed to the phenotypic differences between Reh and U698 cells after IR, and that multiple molecular factors control the radiation response of malignant B lymphocytes. ' 2005 Wiley-Liss, Inc.

show abstract

“…PCNA has been called the ''ringmaster of the genome,'' because this 29-kDa protein has been shown to actively participate in a number of the molecular pathways responsible for the life and death of the mammalian cell (10). There are a number of reports in the literature suggesting that PCNA is, itself, posttranslationally modified, although there is some conflict as to what these modifications may be (11)(12)(13)(14).…”

mentioning

confidence: 97%

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker

Malkas

Herbert

Abdel-Aziz

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

Two isoforms of proliferating cell nuclear antigen (PCNA) have been observed in breast cancer cells. Commercially available antibodies to PCNA recognize both isoforms and, therefore, cannot differentiate between the PCNA isoforms in malignant and nonmalignant breast epithelial cells and tissues. We have developed a unique antibody that specifically detects a PCNA isoform (caPCNA) associated with breast cancer epithelial cells grown in culture and breast-tumor tissues. Immunostaining studies using this antibody suggest that the caPCNA isoform may be useful as a marker of breast cancer and that the caPCNA-specific antibody could potentially serve as a highly effective detector of malignancy. We also report here that the caPCNA isoform functions in breast cancer-cell DNA replication and interacts with DNA polymerase ␦. Our studies indicate that the caPCNA isoform may be a previously uncharacterized detector of breast cancer. mass spectrometry ͉ pathology ͉ posttranslational modification ͉ DNA replication ͉ genome stability

show abstract

Proliferating cell nuclear antigen (PCNA): ringmaster of the genome

Cited by 300 publications

References 123 publications

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

Response of malignant B lymphocytes to ionizing radiation: Gene expression and genotype

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker

Contact Info

Product

Resources

About