Proliferating Trichilemmal Tumor with Apocrine Sweat Glands

Dekio, Satoshi; Imaoka, Chiharu; Jidoi, Joji

doi:10.1111/j.1346-8138.1990.tb01663.x

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…This cancer was not unapparent, yet its bland and slight appearance did raise suspicion in the patient's physicians that he had a cancer. Dekio et al (42) reported a 43-year-old man with a proliferating trichilemmal tumor that appeared on an area of pre-existing alopecia underlined by ectopic apocrine sweat glands. Squamous (spinous) cell carcinoma has occurred in association with SACUMAN (43).…”

Section: Mischellaneous Tumors Of Local Originmentioning

confidence: 99%

Review of Scalp Alopecia due to a Clinically Unapparent or Minimally Apparent Neoplasm (SACUMAN)

Scheinfeld¹

2006

Acta Derm Venereol

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Neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp. However, the infiltration of neoplastic cells is sometimes not florid; a condition known as "scalp alopecia due to a clinically unapparent or minimally apparent neoplasm" (SACUMAN). Neoplastic cells can nevertheless destroy hair follicles by inducing fibroplasias via inflammatory mediators, attracting inflammatory cells and/or replacing normal cellular populations. The infiltrative nature of such an alopecia can be unapparent or only minimally apparent. The most common neoplasm in which an uncomplicated, minimally or unapparent scalp alopecia occurs and no infiltrate of cancer is suspected is metastatic breast carcinoma. Other causes include squamous and basal cell carcinomas, angiosarcoma, gastric carcinoma, placental site tromphoblastic tumor, and mycosis fungoides. Syringoma-like proliferations can underlie alopecia. It is unclear whether these proliferations are true syringomas or normal findings. In conclusion, neoplasms causing cicatricial alopecia of the scalp are very rare, so generalizations from the limited number of case reports are of uncertain importance. Moreover, it is likely that many cases of neoplasms causing cicatricial alopecia of the scalp are diagnosed as inflammatory alopecia and not neoplasms, thus depriving us of a full accounting and understanding of this entity. Dermatologists must be aware that in rare cases a bland scalp alopecia can represent a new or recurring, local or metastatic neoplasm.

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Section: Mischellaneous Tumors Of Local Originmentioning

confidence: 99%

Review of Scalp Alopecia due to a Clinically Unapparent or Minimally Apparent Neoplasm (SACUMAN)

Scheinfeld¹

2006

Acta Derm Venereol

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“…On the other hand, bulge cells can be mobilised to maintain sebaceous glands [48], crossing the isthmus for this purpose [2]. Besides, there are reports of PTT with divergent differentiations, including sebaceous [50] or apocrine [50,51]. Furthermore, there are also examples of association between sebaceous carcinoma and PTT, with no clinical evidence of Muir-Torre or Lynch syndrome [52].…”

Section: Introductionmentioning

confidence: 99%

TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

et al. 2021

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Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on TP53 and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Based on this assumption, but also taking into account the close relationship between the sebaceous ducts and the external root sheath where TC develop, a MMR, a p53 expression assessment and a TP53 study were performed in a series of 5 PTT cases, including a giant one. We failed to demonstrate a MMR disorder on studied PTT, but we agree with previous results suggesting increased p53 expression in these tumours, particularly in proliferative areas. TP53 alteration was confirmed with FISH technique, demonstrating TP53 deletion in most cells.

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Proliferating Tricholemmal Tumor

Requena

Sangüeza

2017

Cutaneous Adnexal Neoplasms

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Proliferating Trichilemmal Tumor with Apocrine Sweat Glands

Abstract: A 43-year-old man with a proliferating trichilemmal tumor is described. Since the tumor had appeared on a pre-existing alopecia and accompanied ectopic apocrine sweat glands, it is supposed that the pathogenesis of the tumor of our patient might be similar to that of an organoid nevus.

Cited by 3 publications

References 7 publications

Review of Scalp Alopecia due to a Clinically Unapparent or Minimally Apparent Neoplasm (SACUMAN)

Review of Scalp Alopecia due to a Clinically Unapparent or Minimally Apparent Neoplasm (SACUMAN)

TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

Proliferating Tricholemmal Tumor

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