Proliferating Trichilemmal Tumors: A Review of the Literature

Satyaprakash, Anita; Sheehan, Daniel J.; Sangüeza, Omar P.

doi:10.1111/j.1524-4725.2007.33225.x

Cited by 123 publications

(218 citation statements)

References 51 publications

(174 reference statements)

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“…The differential diagnosis of MPTT includes basal cell carcinoma, sebaceous carcinoma, squamous cell carcinoma and clear cell hydradenocarcinoma [5]. The treatment of MPTT without metastasis is wide local excision with 1 cm of normal tissue [2,3]. In our case, MPTT with intra-cranial extension and lung metastasis carries a very poor prognosis.…”

Section: Discussionmentioning

confidence: 90%

“…This tumour lacks a distinctive histological or immunohistochemical marker to suggest malignant transformation [4]. The real incidence of MPTT is unknown due to its rarity and also because of its inconsistencies in nomenclature and misclassification as squamous cell carcinoma [2,3]. The treatment of choice for MPTT is surgery with periodic surveillance without adjuvant therapy [4].…”

Section: Discussionmentioning

confidence: 99%

“…PTTs commonly exhibit benign behaviour and rarely present a malignant course. When they invade neighbouring tissues accompanied by anaplasia and necrosis, it is described as a malignant proliferating trichilemmal tumour (MPTT) [2,3]. MPTTs are invasive and metastatic tumours that demonstrate biologically aggressive behaviour [3].…”

Section: Introductionmentioning

confidence: 99%

“…When they invade neighbouring tissues accompanied by anaplasia and necrosis, it is described as a malignant proliferating trichilemmal tumour (MPTT) [2,3]. MPTTs are invasive and metastatic tumours that demonstrate biologically aggressive behaviour [3]. Squamous cell carcinoma (SCC) should be eliminated by a differential diagnosis due to the similarity of disease presentation [3].…”

Section: Introductionmentioning

confidence: 99%

“…MPTTs are invasive and metastatic tumours that demonstrate biologically aggressive behaviour [3]. Squamous cell carcinoma (SCC) should be eliminated by a differential diagnosis due to the similarity of disease presentation [3]. Treatment of MPTTs is controversial because only a limited number of cases are reported in literature.…”

Section: Introductionmentioning

confidence: 99%

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Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis—a Case Report

2016

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Malignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. However at times, the tumour has an aggressive clinical course and a propensity for distant metastasis. We report a case of a 29-year-old male who presented with a scalp swelling. Histology revealed malignant proliferating trichilemmal tumour of scalp. CT thorax showed multiple nodules in both lungs suggestive of lung metastasis. The patient underwent palliative radiotherapy and chemotherapy and expired 2 months after palliation. To the best of our knowledge, malignant proliferating trichilemmal tumour of the scalp with intracranial extension and lung metastasis is a rare condition, and only a handful of cases are reported till date. We report a case of malignant proliferating trichilemmal tumour of the scalp with intra-cranial extension and lung metastasis with relevant discussion at the same time.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis—a Case Report

2016

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Unusual Cutaneous Malignancies

Choueiri

Olencki

Samlowski

et al. 2006

Textbook of Uncommon Cancer

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Tumours of Skin Appendages

Calonje

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter on cutaneous appendageal tumours covers the spectrum of lesions displaying eccrine, apocrine, sebaceous and follicular differentiation. It includes cysts, hamartomas and benign and malignant tumours. Traditionally, appendageal tumours have been classified according to rigid criteria separating lesions with eccrine, apocrine, sebaceous and follicular differentiation. This separation is clearly artificial and it is now acknowledged that lesions regarded as strictly eccrine may well have apocrine differentiation and lesions classified as purely follicular may exhibit apocrine differentiation reflecting the close embryological relationship between the pilosebaceous unit and the apocrine gland.

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Proliferating Trichilemmal Tumors: A Review of the Literature

Abstract: Adequate treatment of PTT requires skilled histopathologic examination for proper diagnosis; histologic appearance may not correlate with clinical behavior. After surgical excision, long-term clinical follow-up for evidence of metastatic disease is judicious.

Cited by 123 publications

References 51 publications

Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis—a Case Report

Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis—a Case Report

Unusual Cutaneous Malignancies

Tumours of Skin Appendages

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