Proliferating trichilemmal tumour: p53 immunoreactivity in association with p27<sup>Kip1</sup> over‐expression indicates a low‐grade carcinoma profile

Fernández‐Figueras, María‐Teresa; Casalots, Àlex; Puig, L.; Llatjós, R; Ferrándiz, Carlos; Ariza, Aurelio

doi:10.1046/j.1365-2559.2001.01149.x

Cited by 27 publications

(18 citation statements)

References 19 publications

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“…In addition, immunohistochemical staining of Ki‐67 and p53 can further help differentiate proliferating trichilemmal cysts from their malignant counterpart . The expression of p53 limited to the basal layer, as seen in our case, supports the diagnosis of a PTC in contrast to random/diffuse p53 expression observed throughout the malignant PTC or squamous cell carcinoma with trichilemmal differentiation . The presence of CD34 can be used to differentiate trichilemmal cysts from squamous cell carcinoma .…”

Section: Discussionsupporting

confidence: 76%

Giant proliferating trichilemmal cyst arising from a nevus sebaceus growing for 30 years

et al. 2017

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Nevus sebaceus of Jadassohn, a congenital cutaneous hamartoma, has the potential to develop into various epidermal adnexal-origin neoplasms. While the most common neoplasms are trichoblastoma or syringocystadenoma, proliferating trichilemmal cysts are exceptionally rare. We report a case of a 63-year-old Cuban male with a giant proliferating trichilemmal cyst arising from a nevus sebaceus on the right shoulder which had been growing for 30 years. Proliferating trichilemmal cysts arising from nevus sebaceus cases are difficult to diagnose clinically and histologically as they are very rare and have not been defined by exact diagnostic criteria. Our case creates awareness of this particular tumor in nevus sebaceus and shares clinical and histological diagnostic information that can be used to make a proper diagnosis.

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Section: Discussionsupporting

confidence: 76%

Giant proliferating trichilemmal cyst arising from a nevus sebaceus growing for 30 years

et al. 2017

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“…[8] Proliferation markers like Ki67 and p53 can assist in the stratification of these cases into the three-tier classification as suggested by Ye et al . [79] Ki 67 was found to be only focally positive in <5% of the basal cells in trichilemmal cysts and benign PPT as compared with 30 to 40% cells in malignant PPT by one of the investigators,whereas our case showed Ki67 positivity in 20% of the cells. [7] The present case highlights the importance of these markers in the diagnosis and subtyping of this tumor.…”

Section: Discussionmentioning

confidence: 45%

Low-grade malignant proliferating pilar tumor simulating a squamous-cell carcinoma in an elderly female: A case report and immunohistochemical study

et al. 2011

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A 65-year-old lady presented with an ulcerated lesion over the occipital region of nine-year duration, an incisional biopsy of which was reported as squamous-cell carcinoma. A wide local excision was performed and the tissue was sent for histopathological examination which revealed a low-grade malignant pilar tumor. Focal invasion and atypia were noted. Immunohistochemical (IHC) analysis revealed positivity for CD34 and calretinin immunomarkers favoring outer root sheath origin. Ki67 immunostains revealed a relatively low immunoreactivity indicating the low-grade nature of the tumor; however, p53 immunostain showed strong diffuse nuclear staining confirming the malignant nature of the tumor. Proliferating pilartumors (PPT) are rare tumors and less than 100 well-documented cases of malignant PPT have been reported so far in the literature. These tumors have been recently classified into benign, low- and high-grade malignant tumors and statistically significant difference was found in their biological behavior. However, we propose that IHC can be of immense value in assisting the subtyping of the tumor, so that the behavior and role of adjuvant therapy can be validated in future studies.

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“…[56] Alternatively, some authors have recently suggested that PTC is a squamous cell carcinoma. [78910] Nevertheless the malignant potential of these tumors is still debated[11] and new strategies for the evaluation of tumor grade are needed. On the other hand, major association between the presence of ki67 and the grade of malignancy has been observed in all tumors which have been studied by ki67 immunostaining.…”

Section: Introductionmentioning

confidence: 99%

Proliferating trichilemmal cyst: The value of ki67 immunostaining

Rangel-Gamboa¹,

Reyes-Castro²,

Domínguez‐Cherit³

et al. 2013

Int J Trichol

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Background:A proliferating trichilemmal cyst (PTC) is an uncommon, rapidly-reproducing cutaneous epithelial cyst, differentiating from the isthmic portion of the outer hair root sheath. It is usually described as a benign tumor, but malignant transformation has been reported and is then denominated as a malignant proliferating trichilemmal tumor. Ki67 immunostaining has been used as a methodology for the evaluation of tumor grade in other tumors, due to its distinctive reaction patterns which exclusively involve proliferating cells.Objectives:(1) To report the incidence of cases of PTCs in a General Hospital during a 12 years period. (2) To determine the expression of ki67 using immunohistochemical staining. (3) To correlate ki67 reaction patterns with clinical prognosis.Materials and Methods:The dermatology department's files during a period of 12 years were reviewed; cases with a diagnosis of PTC were selected, and ki67 immunostaining was done when enough biological material was available.Results:A total of 15 cases with a diagnosis of PTC were identified. In 12 cases, ki67 immunostaining was carried out. In 9 of the 12 cases, ki67 was observed in the basal cells of the cystic epithelium, one case was moderately positive in palisading epithelial cells; in the other two cases ki67 immunostaining was negative. Clinical follow-up was done and revealed that no patient had local recurrence in 5 years after surgical removal of PTC. We therefore consider this immunostaining technique is probably correlated with low recurrence potential.

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Proliferating trichilemmal tumour: p53 immunoreactivity in association with p27^Kip1 over‐expression indicates a low‐grade carcinoma profile

Abstract: The similar p53 immunoreactivity in both PTT and SCCT favour the interpretation of the former as carcinoma, albeit one whose behaviour would be tempered by the well-known regulatory effect exerted by p27Kip1 on the cell cycle.

Cited by 27 publications

References 19 publications

Giant proliferating trichilemmal cyst arising from a nevus sebaceus growing for 30 years

Giant proliferating trichilemmal cyst arising from a nevus sebaceus growing for 30 years

Low-grade malignant proliferating pilar tumor simulating a squamous-cell carcinoma in an elderly female: A case report and immunohistochemical study

Proliferating trichilemmal cyst: The value of ki67 immunostaining

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Proliferating trichilemmal tumour: p53 immunoreactivity in association with p27Kip1 over‐expression indicates a low‐grade carcinoma profile

Abstract: The similar p53 immunoreactivity in both PTT and SCCT favour the interpretation of the former as carcinoma, albeit one whose behaviour would be tempered by the well-known regulatory effect exerted by p27Kip1 on the cell cycle.

Cited by 27 publications

References 19 publications

Giant proliferating trichilemmal cyst arising from a nevus sebaceus growing for 30 years

Giant proliferating trichilemmal cyst arising from a nevus sebaceus growing for 30 years

Low-grade malignant proliferating pilar tumor simulating a squamous-cell carcinoma in an elderly female: A case report and immunohistochemical study

Proliferating trichilemmal cyst: The value of ki67 immunostaining

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Proliferating trichilemmal tumour: p53 immunoreactivity in association with p27^Kip1 over‐expression indicates a low‐grade carcinoma profile