2004
DOI: 10.1016/j.exger.2003.09.026
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Proliferation and apoptosis of human CD8+CD28+ and CD8+CD28− lymphocytes during aging

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Cited by 66 publications
(52 citation statements)
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“…In the latter case, subsets of clonal T cells have limited, or have completely lost, the capacity to divide, suggesting cells that are in advanced stages of senescence (9,10).…”
Section: Cd56 Expression On T Cells Undergoing Replicative Senescencementioning
confidence: 99%
See 1 more Smart Citation
“…In the latter case, subsets of clonal T cells have limited, or have completely lost, the capacity to divide, suggesting cells that are in advanced stages of senescence (9,10).…”
Section: Cd56 Expression On T Cells Undergoing Replicative Senescencementioning
confidence: 99%
“…The number of circulating T cells is nevertheless maintained through life (6), a phenomenon that is attributable in part to increased steady-state homeostatic Ag-independent proliferation in adult life (7,8). However, homeostatic expansion along with clonal proliferation due to persistent or cyclical exposure to Ag lead to telomere erosion that limits the overall mitotic capacity of T cells (5,9,10). There are also functional defects of the TCR with aging.…”
mentioning
confidence: 99%
“…Moreover, with aging, a decrease in CD28+ T cells has been observed, concomitantly with a progressive accumulation of CD28-T lymphocytes both in CD8+ and CD4+ subsets [16,19,20] . These cells display several aspects of senescence, such as oligoclonal expansion, shortened telomeres, limited proliferative potential, production of tumor necrosis factor-␣ (TNF-␣ ) and interleukin (IL)-6 as well as resistance to apoptosis [18,19,[21][22][23][24][25] .…”
Section: Changes In Adaptive Immunitymentioning
confidence: 99%
“…Although CD28 is considered as a biomarker of immunosenescence, its expression can be down-regulated by tumor-necrosis factor (59,60) or up-regulated by IL-12 in CD4ϩ cells (61). It was also shown that CD8ϩCD28-cells are able to proliferate (62) and therefore the loss of CD28 is not necessarily associated with senescence. There is also contradictory evidence concerning loss of the co-stimulatory molecule CD28 and altered downstream signaling.…”
Section: Discussionmentioning
confidence: 99%