Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)

Rameshk, Maryam; Sharififar, Fariba; Mehrabani, Mitra; Pardakhty, Abbas; Farsinejad, Alireza; Mehrabani, Mehrnaz

doi:10.1007/s40199-018-0211-7

Cited by 31 publications

(15 citation statements)

References 40 publications

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“…They are designed to target and control the release of natural compounds. 57,[107][108][109][110] Our group evaluated the niosome encapsulation of different antioxidant phytochemicals, such as lawsone, 58 diosgenin, 111 D-limonene, 111 and Carum spp. 111 In our last study, we designed a natural anti-cancer niosome vesicle based on ergosterol, nonionic surfactants, and Carum carvi extract (Carum).…”

Section: The Niosomementioning

confidence: 99%

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Barani¹,

Sangiovanni²,

Angarano³

et al. 2021

IJN

Self Cite

133

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Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing phytosome technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of biological activities of commercial and non-commercial phytosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of phytosomes, both in terms of biological activity or reduced dosage, highlighting curcumin and silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of phytosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to market, for a further development of these products.

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Section: The Niosomementioning

confidence: 99%

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Barani¹,

Sangiovanni²,

Angarano³

et al. 2021

IJN

Self Cite

133

View full text Add to dashboard Cite

show abstract

“…Niosomes are novel drug-delivery systems, also called non-ionic surfactant vesicles, that might entrap lipophilic drugs into vesicular bilayer membranes and hydrophilic drugs in the aqueous compartments. Therefore, the niosomes can encapsulate both lipophilic and hydrophilic PCs [ 21 , 39 , 84 ]. Niosomal carriers protect the therapeutic agent and improve its stability since the encapsulated drug is stored in a semi-biological environment with a longer shelf-life [ 39 ].…”

Section: Types Of Vesicular Nanosystemsmentioning

confidence: 99%

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

2022

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The need to develop wound healing preparations is a pressing challenge given the limitations of the current treatment and the rising prevalence of impaired healing wounds. Although herbal extracts have been used for many years to treat skin disorders, due to their wound healing, anti-inflammatory, antimicrobial, and antioxidant effects, their efficacy can be questionable because of their poor bioavailability and stability issues. Nanotechnology offers an opportunity to revolutionize wound healing therapies by including herbal compounds in nanosystems. Particularly, vesicular nanosystems exhibit beneficial properties, such as biocompatibility, targeted and sustained delivery capacity, and increased phytocompounds’ bioavailability and protection, conferring them a great potential for future applications in wound care. This review summarizes the beneficial effects of phytocompounds in wound healing and emphasizes the advantages of their entrapment in vesicular nanosystems. Different types of lipid nanocarriers are presented (liposomes, niosomes, transferosomes, ethosomes, cubosomes, and their derivates’ systems), highlighting their applications as carriers for phytocompounds in wound care, with the presentation of the state-of-art in this field. The methods of preparation, characterization, and evaluation are also described, underlining the properties that ensure good in vitro and in vivo performance. Finally, future directions of topical systems in which vesicle-bearing herbal extracts or phytocompounds can be incorporated are pointed out, as their development is emerging as a promising strategy.

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“…In this regard, niosome loaded resveratrol for topical treatment of skin cancers is one of the potential candidate. 99,100 Similarly, the topical gel from Zingiber cassumunar Roxb. extract loaded niosome for anti-inflammatory activity-enhanced skin permeation and stability of compound D was developed using croton oil-induced ear edema model in male ICR mice.…”

Section: Transferosomementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

156

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)

Abstract: Formulation of PEN in niosome carrier significantly decreased the gap width on human dermal fibroblasts. Graphical abstract Schematic processes of proliferation effect of narcisus tazetta bulb on fibroblast cells.

Cited by 31 publications

References 40 publications

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

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