Proliferation characteristics of erythroblasts in chronic renal failure

Kempgens, U.; Mayer, M; Schautt, B.; Queißer, W.

doi:10.1007/bf01006963

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…A close correlation between glomerulus filtrate and hemoglobin concentration has been noted; in children, r = 0.73 [29]. The two pathoge netic components discussed in renal anemia are an aplastic disorder of the bone marrow, related with an erythropoietine deficiency, and a shortened erythrocyte survival of hitherto unknown reason [1,4,6, 8, 15,[18][19][20][21][22][23][24][38][39][40],In patients with terminal renal insuffi ciency, erythrocyte survival was reduced to 30-60% of the normal value [12, 13]. The hemolytic aspect of anemia in uremia is thought to be caused by alterations in the structure and function of the erythrocytes induced by elevated concentrations of toxic substances in the plasma [21-23, 27, 35, 38-40], The hemolysis-promoting effect of…”

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confidence: 99%

Erythrocyte and Plasma Lipids in Terminal Renal Insufficiency

Bleiber¹,

Eggert²,

Reichmann³

et al. 1980

Acta Haematol

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Lipids in erythrocytes and plasma of children and adults with terminal renal insufficiency were determined and compared with those of normal controls. The erythrocyte phospholipids in uremic patients were altered in phosphatidylethanolamine (absolutely and relatively elevated) and in lecithin (relatively diminished). Sphingomyelin, phosphatidylserine, total erythrocyte phospholipid content and cholesterol were within the normal range. The detailed analysis of the distribution of plasma phospholipids showed an increase in all phospholipids except phosphatidylserine. The unesterified plasma cholesterol was also found to be elevated. The fatty acid distribution in the individual erythrocyte phospholipids showed the following variations in comparison with controls: one main fatty acid was significantly decreased in sphingomyelin and in lecithin and slightly decreased in phosphatidylethanolamine. It could be shown that the lipid alterations in uremic erythrocytes were quite different from those in plasma. There were no typical signs for an increased lipid peroxidation in the erythrocytes of patients with renal insufficiency.

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confidence: 99%

Erythrocyte and Plasma Lipids in Terminal Renal Insufficiency

Bleiber¹,

Eggert²,

Reichmann³

et al. 1980

Acta Haematol

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Erythropoese

Remmele¹

1984

Pathologie

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In vitro studies of bone marrow stem-cell function in uraemic children

Hellwege¹,

Bläker²,

Neth³

1978

Eur J Pediatr

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Abstract. Anaemia is a frequent symptom in children with chronic uraemia.There is only limited information about committed haemopoietic stem-cell function in renal insufficiency. The ability of bone-marrow cells to form erythropoietic and granulopoietic cell colonies in vitro was therefore tested in 13 children with chronic renal insufficiency.Following separation of mononuclear cells from bone-marrow aspirates by Ficoll-Isopaque gradient centrifugation, erythropoietic precursor cells were stimulated in plasma clots by erythropoietin. Granulopoietic precursor cells were stimulated in soft-agar gel using feeder layers of normal human leukocytes. The colonies were identified by staining and counted.The number and proliferative capacity of erythropoietic precursor cells (CFU-E) did not seem to be significantly suppressed. Under in vitro conditions, the responsiveness of CFU-E to erythropoietin seemed to be normal.Addition of autologous serum resulted in different degrees of inhibition of erythroid colony formation. The inhibitory effect of the sera was also obvious when uraemic sera were added to bone-marrow cells from subjects without renal disease. Preliminary data indicate that haemodialysis is effective in reducing this inhibitory activity which may be an important factor in the pathogenesis of anaemia in chronic renal insufficiency. The numbers and proliferative capacity of granulopoietic precursor cells (CFU-C) were normal in all the children tested.Key words: Human CFU-E -Human CFU-C -Bone marrow cultureErythropoiesis -Granulopoiesis -Renal anaemia-Uraemia.Anaemia is a well-known complication of chronic renal insufficiency but the relationship between the severity of anaemia and degree of uraemia is not linear. The anaemia is normochromic and normocytic unless modified by iron or folic acid deficiency. Uraemic toxins, possibly causing increased membrane fragility or

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Proliferation characteristics of erythroblasts in chronic renal failure

Cited by 4 publications

References 11 publications

Erythrocyte and Plasma Lipids in Terminal Renal Insufficiency

Erythrocyte and Plasma Lipids in Terminal Renal Insufficiency

Erythropoese

In vitro studies of bone marrow stem-cell function in uraemic children

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