Proliferation hemangiomas formation through dual mechanism of vascular endothelial growth factor mediated endothelial progenitor cells proliferation and mobilization through matrix metalloproteinases 9

Zhang, Guoyou; Yi, Chenggang; Li, Xuan; Liang, Zhongxing; Run-xiu, Wang; Liu, Da-en; Zhang, Liming; Chengyue, Meng; Guo, Shuzhong

doi:10.1016/j.mehy.2007.06.042

Cited by 18 publications

(14 citation statements)

References 16 publications

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“…Der Sauerstoffmangel löst die Produktion des Hypoxie‐induzierten Faktors 1‐alpha (HIF‐1α) aus, der die Transkription des VEGF‐Gens induziert. Dieses stimuliert wiederum die Proliferation und die Migration von Endothelprogenitorzellen, was zur Bildung von neuen Gefäßen und zur Synthese von Proteinasen (Metalloproteinasen) führt. Diese sind an der Umstrukturierung der extrazellulären Matrix beteiligt .…”

Section: Die Pathogenese Des Infantilen Hämangiomsunclassified

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Das infantile Hämangiom: Pathogenese und Wirkmechanismus von Propranolol

Rotter

Oliveira

2017

J Deutsche Derma Gesell

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SummaryInfantile hemangioma (IH) is the most common benign tumor of childhood, with a prevalence of 4 % to 10 %. It is characterized by a proliferative rapid growth phase, which starts after a few weeks of life, followed by a slow regression phase. In IH cases that are potentially disfiguring or life-threatening (10 % to 15 % of all cases), systemic therapy should be promptly initiated. Data source: The present study reviews published scientific articles available in reliable electronic databases. Selected were all studies that evaluated the pathogenesis of IH and the mechanisms of action of propranolol. Conclusions: The pathogenesis of IH has not been fully elucidated. Studies show that, in the proliferative phase of IH, there is an imbalance of angiogenic factors and an increase in the levels of vascular endothelial growth factor and matrix-metalloproteinases 2 and 9. In the regression phase, the levels of these factors decrease, whereas

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Section: Die Pathogenese Des Infantilen Hämangiomsunclassified

“…Mehrere Studien haben einen Anstieg bei der Expression des VEGF während der Proliferationsphase des IH ergeben. In der Regressionsphase steigt die Expression von TIMP an, während die von VEGF abnimmt . In einigen Studien wurde der Anstieg der Serumspiegel von VEGF bei Patienten mit IH untersucht .…”

Section: Die Pathogenese Des Infantilen Hämangiomsunclassified

Das infantile Hämangiom: Pathogenese und Wirkmechanismus von Propranolol

Rotter

Oliveira

2017

J Deutsche Derma Gesell

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“…The process may also result from the disturbed balance between pro-angiogenetic factors and angiogenesis inhibitors [23]. VEGf and bfGf [24], metalloproteinases 2 and 9 [25], angiopoietins (ang-1, ang-2) -acting by localization of tyrosine kinase specific receptors [26], insulin resembling growth factor (IGf-2) and E-selectin [27] play the most important role among angiogenesis promotors. The theory of hemangioma placental origin suggests that foetal vessels embolization with the placental origin cells is a direct reason for tumour formation.…”

Section: Theories Of Infantile Hemangiomas Formation and Syndromes Comentioning

confidence: 99%

Epidemiology, Diagnostics and Treatment of Vascular Tumours and Malformations

Wójcicki¹,

Wójcicka²

2014

Adv Clin Exp Med

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Vascular tumours and vascular malformations are common vasculose anomalies characteristic for dissimilar clinical course, specific biological as well as immune cytological and histological properties. Vascular lesions classification system and their detailed division into groups and subgroups were elaborated and implemented in Rome, in 1996, during meeting of the International Society for the Study of Vascular anomalies (ISSVa). It was based on modification of an earlier going division by Mullikien and Głowacki from 1982. Infantile hemangiomas are the most numerous group of benign tumours of mesenchymal origin. Vascular malformations appear definitely less often. They are composed of normal endothelium lined displastic vessels which originate from vascular tissue abnormal morphogenesis. In contrast, in hemangiomas, at the proliferation stage, increased, multiplication of endothelial cells is observed as well as of fibroblasts, mastocytes and macrophages. Infantile hemangiomas are usually not present at the moment of birth and white chloasma with superficial teleangiectasis appears which increases within 3-4 weeks and gets bright red colour and reveal very characteristic clinical course basing on intensive growth period and involution long process. Vascular malformations are observed most often at the delivery moment or they may appear at an early childhood. They enlarge proportionally along with the child's growth and their sudden expansion may be triggered by an infection, hormonal changes or trauma. Contrary to hemangiomas, they do not subside spontaneously and their abrupt increase may result in impairment or deformation of important anatomical structures. Infantile hemangiomas and vascular malformations require different and individual treatments which are often multi-stage procedures carried on in specialistic centres of plastic surgery, vascular surgery or maxillofacial surgery (Adv Clin Exp Med 2014, 23, 3, 475-484).

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“…According to the extrinsic theory, growth factors, an abnormal hormonal milieu, such as increased oestrogen levels, or tissue hypoxia, which leads to increased expression of hypoxia inducible factor (HIF1 a) and ultimately the stimulation of angiogenesis via vascular endothelial growth factor (VEGF), underlie hemangioma development (Zhang et al, 2008). It is believed that a nascent hemangioma may result from endothelial proliferation secondary to increased levels of growth stimulating factors or decreased levels of growth-inhibitory factors normally present in the tissue (Mulliken and Glowacki, 1982).…”

Section: Issn: Online 1696-3547 Print 0214-6282mentioning

confidence: 99%

“…In a separate study, VEGF and high molecular weight matrix metalloproteinases (MMPs) were found to be elevated in urine samples of patients with proliferative hemangiomas (Zhang et al, 2008). Matrix metalloproteinases are involved in the degradation of extracellular matrix components during the angiogenic process (Pepper, 1997).…”

Section: Role Of Angiogenesismentioning

confidence: 99%

Hemangiomas - current therapeutic strategies

Mabeta

Pepper²

2011

Int. J. Dev. Biol.

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Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present with complications, and may thus require treatment. There are multiple therapeutic options available for patients with problematic or life threatening hemangiomas, some of which have serious side effects. Randomized clinical trials and evidencebased studies on the efficacy of these treatments is still lacking. The recognition that excessive angiogenesis underlies hemangiogenesis offers an opportunity for the development of safer therapeutic strategies that are based on the inhibition of angiogenesis. We review medical therapies currently employed in the management of hemangiomas and the role of angiogenesis inhibition in hemangioma therapy.

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Proliferation hemangiomas formation through dual mechanism of vascular endothelial growth factor mediated endothelial progenitor cells proliferation and mobilization through matrix metalloproteinases 9

Cited by 18 publications

References 16 publications

Das infantile Hämangiom: Pathogenese und Wirkmechanismus von Propranolol

Das infantile Hämangiom: Pathogenese und Wirkmechanismus von Propranolol

Epidemiology, Diagnostics and Treatment of Vascular Tumours and Malformations

Hemangiomas - current therapeutic strategies

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