Proliferation in pleomorphic adenoma: Lights and shadow on this parameter, in a neoplasm showing unpredictable behavior–An immunohistochemical study and review of the literature

Rosa, Filippo De; Pignatiello, Sara; Sibillo, Maria Cristina; Guadagno, Elia

doi:10.1016/j.prp.2021.153748

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…20 Higher values of Ki67 were found among cases with larger size (p = 0.0061) and showing greater cellularity (p =0.0004). 21 In another study, expression of Ki-67 was not observed in benign mixed SGTs however in current study, 50% cases expressed weak positive (5 to 19 cells) and 50% expressed negative. 22 Finding of another local study showed that mean age of patients of PAs was 34.13 years with male predominance contrary to our study and most common site was parotid salivary glands similar to current study.…”

Section: Discussioncontrasting

confidence: 57%

“…The majority of studies reported Ki-67 expression is negative to weak positive and some studies reported moderate to strong positive. 11,12,16,17,18,19,20,21,25 The results of these studies indicate that biological behavior of PAs is different in cases which recur and transform to malignancy and also show high expression of Ki-67. During routine histopathological examination of PAs when mitotic figures are observed more, then Ki-67 expression may be suggested to observe its early transformation to malignancy (CaExPAs).…”

Section: Discussionmentioning

confidence: 94%

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Mitotic Index and Immunohistochemical Expression of Ki-67 in Pleomorphic Adenoma of Salivary Glands

Rasul¹

2022

J Islamabad Med Dental Coll

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. Background: Pleomorphic adenomas (PAs) are the most common type of salivary gland tumors (SGTs) which may undergo malignant transformation to Carcinoma ex PA (CaExPA). The purpose of this study was to determine mitotic index (MI) and expression of Ki-67 in Pleomorphic adenomas of salivary gland tumors. Methodology: This study was carried out on sixty patients of pleomorphic adenoma. Slides with specimens were stained with Hematoxylin & Eosin to count Mitotic index. Labeling Index (LI) of Ki-67 was determined immunohistochemically. Mitotic figures (MF) were counted in 10 HPF selected in the proliferative area. MI was scored as 1 (0 to 4 MF per 10 HPF); 2 (5-9 MF per 10 HPF) and 3 (> 9 MF per 10 HPF). Immunoexpression of Ki-67 was scored as ‘0-negative’ when <5% of neoplastic cells stained, ‘1-weak positive’ when 5-19% of neoplastic cells were stained, ‘2-moderate positive’ when 20-49% of neoplastic cells were stained, and ‘3-strong positive’ when >50% of neoplastic cells were stained with Ki-67. Data was, entered in SPSS 21. Results: Mean age was 38.7 ± 12.86 years. Out of 60 cases, 26 (43.33%) were of males while 34 (56.67%) were of females. Expression of Ki-67 was negative in 50% while remaining weak positive. Only score 01 of MI observed. Conclusion: Ki-67 is more sensitive marker than mitotic index in pleomorphic adenomas even in small sized tumors and it can help in detection of malignant transformation of PAs. Keywords: Adenomas, Immunohistochemistry, Ki-67 Antigen, Parotid Neoplasms, Pleomorphic

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 94%

Mitotic Index and Immunohistochemical Expression of Ki-67 in Pleomorphic Adenoma of Salivary Glands

Rasul¹

2022

J Islamabad Med Dental Coll

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The quality and clinical translation of radiomics studies based on MRI for predicting Ki-67 levels in patients with breast cancer

Wang,

Mei,

Gong

2023

The British Journal of Radiology

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Objective: To evaluate the methodological quality of radiomics literature predicting Ki-67 levels based on MRI in patients with breast cancer (BC) and to propose suggestions for clinical translation. Methods: In this review, we searched PubMed, Embase, and Web of Science for studies published on radiomics in patients with BC. We evaluated the methodological quality of the studies using the Radiomics Quality Score (RQS). The Cochrane Collaboration’s software (RevMan 5.4), Meta-DiSc (v. 1.4) and IBM SPSS (v. 26.0) were used for all statistical analyses. Results: Eighteen studies met our inclusion criteria, and the average RQS was 10.17 (standard deviation [SD]: 3.54). None of these studies incorporated any of the following items: a phantom study on all scanners, cut-off analyses, prospective study, cost-effectiveness analysis, or open science and data. In the meta-analysis, it showed apparent diffusion coefficient (ADC) played a better role to predict Ki-67 level than dynamic contrast-enhanced (DCE) MRI in the radiomics, with the pooled area under the curve (AUC) of 0.969. Conclusion: Ki-67 index is a common tumor biomarker with high clinical value. Radiomics is an ever-growing quantitative data-mining method helping predict tumor biomarkers from medical images. However, the quality of the reviewed studies evaluated by the RQS was not so satisfactory and there are ample opportunities for improvement. Open science and data, external validation, phantom study, publicly open radiomics database and standardization in the radiomics practice are what researchers should pay more attention to in the future. Advances in knowledge: The RQS tool considered the radiomics used to predict the Ki-67 level was of poor quality. ADC performed better than DCE in radiomic prediction. We propose some measures to facilitate the clinical translation of radiomics.

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Long-standing pleomorphic adenoma in hard palate: A rare case report

Hanafiah,

Dohude,

Ayuni HG

et al. 2024

Dent. J.

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Background: Pleomorphic adenoma (PA) is the most common benign tumor of the parotid gland, followed by the submandibular gland, and rarely in the minor salivary glands. However, it has the potential to turn malignant. The minor salivary gland in the hard palate is a rare site for PA. Purpose: This report aims to describe the clinical and histopathology findings and treatment with surgical excision of long-standing PA on the hard palate. Case: 40-year-old woman with an asymptomatic 6 x 4 x 4 cm hard palate tumor mass that had remained untreated for ten years and had no preceding trauma. Case Management: The tumor mass was removed surgically by creating an excision opening of 2–3 mm between the mass margin and the maxillary bone periosteum, extending to the posterior palate. Histopathology findings confirmed the diagnosis of PA in the minor salivary gland and revealed typical characteristics associated with malignant transformation. Observation after one month showed that the surgical wound had healed, and no symptoms of recurrence were visible. Conclusion: PA is a benign salivary gland tumor that has the potential to expand extensively. Appropriate surgical excision can improve the prognosis.

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Proliferation in pleomorphic adenoma: Lights and shadow on this parameter, in a neoplasm showing unpredictable behavior–An immunohistochemical study and review of the literature

Cited by 4 publications

References 41 publications

Mitotic Index and Immunohistochemical Expression of Ki-67 in Pleomorphic Adenoma of Salivary Glands

Mitotic Index and Immunohistochemical Expression of Ki-67 in Pleomorphic Adenoma of Salivary Glands

The quality and clinical translation of radiomics studies based on MRI for predicting Ki-67 levels in patients with breast cancer

Long-standing pleomorphic adenoma in hard palate: A rare case report

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