Proliferation of lens epithelial cells on the Acrysof intraocular lens: clinical and histological features of a case

Abstract

Postoperative deposits on the surface of intraocular lenses (IOLs) have been demonstrated in vivo for many IOL material types. The Acrysof acrylic lens develops a granular material extending from the capsulorhexis margin onto the IOL's anterior surface during the first 4 weeks after surgery in a significant proportion of cases. Complete resolution of this membrane occurs by 3 months in almost all cases. The case is presented of an 81-year-old woman who had a persisting membrane coverng the IOL surface at 6 months. This membrane was removed surgically and pathology showed the constituent cells to be of lens epithelial cell origin.

Systematic review of potential causes of intraocular lens opacification

“…Of the 45 articles, five did not fulfil the inclusion criteria and were excluded from further analysis. The remaining included articles numbered 40 and were analysed using the Pierson tool …”

Centripetal lens epithelial cell migration: a prospective study of the Alcon SA60AT intraocular lens

“…Thus the development of opacification on the anterior surface of the intraocular lens (IOL) central to the edge of the capsulorhexis – a recently noted manifestation with the use of acrylic lenses – may well have been overlooked by the majority of ophthalmologists. The significance of this phenomenon is currently being debated, 2–6 and in the case by Turner and House, 6 the constituent cells were shown to be of lens epithelial cell (LEC) origin.…”

Biological Compatibility of Polymethyl Methacrylate, Hydrophilic Acrylic and Hydrophobic Acrylic Intraocular Lenses

“…Histopathological studies have shown the cellular sheet outgrowth to be of LEC in origin [9,32] . Our results exhibited the tendency of these cells to outgrow on the peripheral area of the IOLs ( fi g. 2 a, 3 a), suggesting that they represent the interaction with the lens anterior capsule, while the migration from the equator of the capsular bag is reported to have a minor role [8] .…”

“…The concept of biocompatibility of intraocular lenses (IOLs) can be categorized into two groups: the biological compatibility that is infl uenced by the interaction of biomaterial factors [1][2][3][4][5] with the number of host factors [6,7] , and the mechanical compatibility that is infl uenced by some aspects of the IOL design like optic-haptic design [8,9] .…”