Proliferation of peripheral blood lymphocytes of feeder calves in response to chromium

Chang, X.; Mallard, Bonnie A.; Mowat, D. N.

doi:10.1016/s0271-5317(05)80486-5

Cited by 29 publications

(20 citation statements)

References 21 publications

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“…LIEN et al (2005) used Escherichia coli LPS as a stress inducing agent in weanling pigs with supplementation of 0.2 mg Cr-propionate/kg DM, and found a higher lymphocyte blastogenic response. An increased blastogenic response of lymphocytes in Cr supplemented animals was also reported by CHANG et al (1994). In contrast to the present study, VAN HEUGTEN and SPEARS (1997) did not ascribe any effect of supplemental Cr on cell mediated and humoral immune response in calves.…”

Section: Discussioncontrasting

confidence: 72%

“…DEKA et al (2014) showed that periparturient Murrah buffaloes supplemented with 1.5 mg inorganic Cr/kg DM had higher B and T-cell proliferation. CHANG et al (1994) observed 70% increased lymphocyte blastogenesis in response to Con A in calves receiving 1.0 ppm supplemental chelated-Cr. LIEN et al (2005) used Escherichia coli LPS as a stress inducing agent in weanling pigs with supplementation of 0.2 mg Cr-propionate/kg DM, and found a higher lymphocyte blastogenic response.…”

Section: Discussionmentioning

confidence: 82%

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Supplemental chromium in cold-stressed buffalo calves (Bubalus bubalis): effects on growth performance, nutrient utilization and cell mediated and humoral immune response

Kumar¹

2017

Vet. arhiv

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Various stressors significantly increase urinary excretion of chromium (Cr), suggesting that Cr may be physiologically linked to the responses to control stress. The aim of this study was to determine the physiological responses of buffalo calves to increased Cr supply under low ambient temperature. In a randomized complete block design, twenty-four Murrah buffalo calves were assigned to 4 treatments for a period of 120 days. Treatments included either no supplemental Cr (control), 0.5 mg of supplemental Cr/kg DM, 1.0 mg of supplemental Cr/kg DM, or 1.5 mg of supplemental Cr/kg DM. Buffalo calves were monitored daily for physiological variables, dry matter intake (DMI) and fortnightly for body mass change. Blood samples were collected at fortnightly intervals and analyzed for the biomarkers of immunity and plasma trace mineral concentration. At the end of the 120 day experimental period, a 7 day metabolic trial was conducted. The average temperature-humidity index (THI) and relative humidity (RH) during the study were 58.10 units and 52.0% respectively. Physiological variables, DMI and growth performance did not differ among all treatments. 1.5 mg Cr/kg DM increased B and T-cell proliferation, neutrophil phagocytic activity and ferric reducing antioxidant power (FRAP) value, whereas plasma total immunoglobulin (TIg) and immunoglobulin G (IgG) concentrations were the highest in the 1.0 and 1.5 mg Cr/kg DM group. Nutrient digestibility, nitrogen (N) metabolism and trace mineral bioavailability did not differ between treatments, while the bioavailability of Cr showed a positive correlation with supplemental Cr level. The results suggest that in cold conditions, increased Cr supply can improve immune response without affecting physiological response, growth performance and nutrient utilization in buffalo calves.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 82%

Supplemental chromium in cold-stressed buffalo calves (Bubalus bubalis): effects on growth performance, nutrient utilization and cell mediated and humoral immune response

Kumar¹

2017

Vet. arhiv

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“…The enhanced blastogenesis observed did not appear to be related to concentrations of insulin or other hormones present in serum from Cr-supplemented cows. Direct addition of Cr as either a Cr-amino acid chelate or CrCl 3 to lymphocytes obtained from nonCr-supplemented cattle also increased blastogenic response to Con A stimulation (Chang et al 1994(Chang et al , 1996.…”

Section: Chromiummentioning

confidence: 92%

Micronutrients and immune function in cattle

2000

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Complex inter-relationships exist between certain micronutrients, immune function and disease resistance in cattle. Several micronutrients have been shown to influence immune responses. The relationship between deficiencies of some micronutrients and disease resistance is less clear. A number of studies have indicated that Cr supplementation may improve cell-mediated and humoral immune response as well as resistance to respiratory infections in stressed cattle. With respiratory-disease challenge models Cr generally does not affect disease resistance. Deficiencies of Cu, Se, vitamin E and Co in cattle reduce the ability of isolated neutrophils to kill yeast and/or bacteria. Cu deficiency reduces antibody production, but cell-mediated immunity is generally not altered. However, Cu deficiency appears to reduce production of interferon and tumour necrosis factor by mononuclear cells. Numerous studies have linked low vitamin E and/or Se status to increased susceptibility of dairy cows to intramammary infections. In contrast to findings in laboratory animals, marginal Zn deficiency does not appear to impair antibody production or lymphocyte responsiveness to mitogen stimulation in ruminants. Co deficiency has been associated with reduced resistance to parasitic infections. It is well documented that vitamin A-deficient animals are more susceptible to various types of infections. β-Carotene, possibly via its antioxidant properties, may affect immune function and disease resistance independent of its role as a precursor of vitamin A.

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“…However, in the present investigation the widening of neutrophil : lymphocyte ratio in the control group vis-à -vis the narrowing of the same in the 1Cr group was not likely to be a sequel of stress, rather it might be due to an increased percentage of lymphocytes in the latter dietary group. Dietary Cr supplementation reportedly increased the proliferation of peripheral blood lymphocytes in vitro with or without mitogenic stimulation (Burton et al, 1993;Chang et al, 1994) and it is possible that supplemental Cr played the same role during the present investigation also. The goats were fed with a basal diet devoid of supplemental Cr (control) and the basal diet supplemented with 0.5 mg Cr/kg diet (1Cr) for 60 days (n 5 6 per treatment group).…”

Section: Discussionmentioning

confidence: 58%

Effects of dietary chromium supplementation on glucose tolerance and primary antibody response against peste des petits ruminants in dwarf Bengal goats (Capra hircus)

Haldar

Mondal

Samanta

et al. 2009

Animal

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An experiment was conducted to exploit the immune-modulation effect of trivalent chromium (Cr) for augmenting immunity against peste des petits ruminants (PPR) in dwarf black Bengal goats (Capra hircus). The goats (n 5 6 per treatment group) either received a basal diet devoid of supplemental Cr (control) or were supplemented with 0.5 mg Cr as chromic chloride (1Cr) for 60 days. Live weight gain and feed conversion efficiency improved (P , 0.05) in the 1Cr dietary group. Supplemental Cr did not affect the total number of monocytes, eosinophils and basophils (P . 0.1) although total leukocytes increased (P , 0.05) and the ratio of neutrophils to lymphocytes narrowed down (P , 0.05) in the 1Cr dietary group. The effect of Cr supplementation on variables of the intravenous glucose tolerance test (IVGTT) was inconclusive. Compared to the control group, the basal concentration of glucose (P , 0.05) and insulin (P , 0.001) was higher, clearance rate was slower (P , 0.05) and serum half-life was greater (P , 0.05) in the 1Cr dietary group during the IVGTT. Over the duration of the experiment, serum concentration of insulin increased (P , 0.001) and that of cortisol decreased (P , 0.01) in the 1Cr group, which also showed a relatively higher primary antibody (Ab) response against PPR on days 10 (P , 0.01) and 20 (P , 0.05) post-vaccination. In conclusion, the experiment indicated that supplementation of Cr as CrCl 3 , in the diet of non-stressed goats, may improve primary Ab response against PPR and help confer an augmented immunity to the disease besides promoting growth and feed conversion.

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Proliferation of peripheral blood lymphocytes of feeder calves in response to chromium

Cited by 29 publications

References 21 publications

Supplemental chromium in cold-stressed buffalo calves (Bubalus bubalis): effects on growth performance, nutrient utilization and cell mediated and humoral immune response

Supplemental chromium in cold-stressed buffalo calves (Bubalus bubalis): effects on growth performance, nutrient utilization and cell mediated and humoral immune response

Micronutrients and immune function in cattle

Effects of dietary chromium supplementation on glucose tolerance and primary antibody response against peste des petits ruminants in dwarf Bengal goats (Capra hircus)

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