Proliferation of rat cardiac stem cells is induced by 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside in vitro

2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐β‐glucoside potentiates self‐renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

“…Previous in vitro and in vivo studies have revealed that THSG can increase proliferation of rat cardiac stem cells, and facilitate differentiation of intrinsic neonatal cardiomyocytes to replace damaged heart tissues in models of rat myocardial infarction (Song et al . , ). On the other hand, infection and inflammatory reactions from periodontal disease may damage the surrounding hard and soft tissue structures, the periodontal attachment which requires the alveolar bone, periodontal ligaments and cementum, and ultimately results in tooth loss (Lindhe & Nyman ).…”

“…Furthermore, another study reported that Fallopia multiflora can induce proliferation and differentiation of stem cells (Song et al . ). However, there is no evidence for the capability and mechanisms of THSG‐induced proliferation in hDPSCs.…”

Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy

“…TSG is a free radical-scavenger [22], and exerts anti-aging effects in mammals via a neural insulin/IGF-1 signaling pathway [19]. TSG exhibits strong anti-oxidative and anti-inflammatory effects, as well as protecting mammals from cerebral ischemia and/or reperfusion injury [23, 43]. The ability for TSG to induce proliferation of cardiac stem cells as well as the transcription and differentiation of cardiomyocyte genes has been validated.…”

“…The ability for TSG to induce proliferation of cardiac stem cells as well as the transcription and differentiation of cardiomyocyte genes has been validated. These new cardiomyocytes could repair damaged cardiac muscles after myocardial infarction [43]. Cell damage induced by LPC has been attributed to activation of Notch signaling, and TSG has been shown to protect HUVECs from LPC-induced damage by suppression of the activation of Notch signaling [21].…”

Cardiac stem cell transplantation with 2,3,5,4′-tetrahydroxystilbehe-2-O-β-d-glucoside improves cardiac function in rat myocardial infarction model

“…Rat CSCs were obtained from primary culture, as described in our previous work [27] and other reports [28,29]. Cultured CSCs were prepared from neonatal (one-day old) SD rats, and purified through collagenase digestion, using 0.25% trypsin (HyClone, Logan, UT, USA) for three fiveminute periods, followed by 0.1% collagenase II (Sigma Aldrich, St. Louis, MO, USA) for three 10-min periods.…”