Proliferative and Apoptotic Status in Endometrial Adenocarcinoma

Kuwashima, Y; Uehara, Tomoko; Kishi, Kiyozo; Shiromizu, Kenji; Matsuzawa, Masumi; Takayama, Shojiro

doi:10.1097/00004347-199501000-00008

Cited by 10 publications

(3 citation statements)

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“…In general, the immunohistochemical profile of the sporadic endometrial cancers was in accordance with previous studies 3,19–31 . In the present study, the mean Mib‐1 labelling index was 25%, which is slightly lower than that reported by others, 30–40% 11,31–33 . The manner of selection of the control group could explain this slight discrepancy in Mib‐1 labelling index.…”

Section: Discussionsupporting

confidence: 91%

“…3,[19][20][21][22][23][24][25][26][27][28][29][30][31] In the present study, the mean Mib-1 labelling index was 25%, which is slightly lower than that reported by others, 30-40%. 11,[31][32][33] The manner of selection of the control group could explain this slight discrepancy in Mib-1 labelling index. The Mib-1 labelling index in the sporadic endometrial cancers seemed to be predominantly regulated by cyclin E. Previously cyclin B1 and E have been reported to be involved in the regulation of proliferation in endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

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Cell cycle regulators and apoptosis‐associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma

Rijcken¹,

Zee²,

Sluis

et al. 2006

Histopathology

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Cell cycle regulators and apoptosis‐associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma

Rijcken¹,

Zee²,

Sluis

et al. 2006

Histopathology

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“…MIB-1 is a monoclonal antibody that recognizes a nuclear antigen that is expressed in all cell cycle phases except G 0 . MIB-1 monoclonal antibody is a reliable means of assessing the growth fraction of normal tissues and has been used to study the cell proliferation in various cancers (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Markers of Proliferative Activity Are Predictors of Patient Outcome for Low-Grade Endometrioid Adenocarcinoma But Not Papillary Serous Carcinoma of Endometrium

et al. 2002

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On the basis of pathogenesis, two types of endometrial cancer can be recognized. Type 1 endometrial carcinomas are relatively indolent tumors that develop after prolonged estrogen stimulation, on a background of endometrial hyperplasia. Type 2 endometrial carcinomas are aggressive tumors that are not associated with hyperplasia or estrogen excess. The aim of this study is to evaluate the prognostic significance of tumor proliferative activity in early-stage endometrial cancer by using mitotic index and immunostaining, comparing Type 1 (endometrioid) and Type 2 (papillary serous carcinoma) tumors. The mitotic index, MIB-1, and p53 immunostaining in 39 tumors from patients with lowgrade Stage Ia or Ib endometrioid adenocarcinoma; as well as 23 tumors from patients with Stage I papillary serous carcinoma. In low-grade endometrioid adenocarcinoma, mitotic and MIB-1 indices were statistically significant independent prognostic indicators (P ‫؍‬ .004 and P ‫؍‬ .018, respectively), and both were strongly correlated with p53 expression (P ‫؍‬ .01 and P ‫؍‬ .006, respectively). The mean mitotic index was 5 mitoses/10 high-power fields, and mean MIB-1 index was 27.5%. There was no significant correlation between mitotic or MIB-1 indices and patient outcome or p53 expression in papillary serous carcinoma. The mean mitotic index was 31 mitoses/10 high-power fields, and mean MIB-1 index was 30.5% in these tumors. p53 expression and proliferative indices are strongly correlated in low-grade endometrioid adenocarcinoma. MIB-1 and mitotic indices are independent prognostic indicators in these tumors. Papillary serous carcinoma of endometrium is rapidly proliferative in tumors even at an early stage, and quantification of proliferative activity in these tumors does not allow prediction of patient outcome. KEY WORDS: Endometrial carcinoma, MIB-1, Mitotic index, p53, Papillary serous carcinoma, Proliferative activity. Mod Pathol 2002;15(4):365-371Endometrial cancer is the fourth most common malignancy in North American women. In the United States, there are 33,000 newly diagnosed cases and 4,000 deaths per year (1, 2). On the basis of the proposed dualistic model of endometrial carcinogenesis, there are two types of endometrial carcinoma that differ with regard to epidemiologic risk factors, histopathologic lesions, and molecular events (3). Type 1 endometrial carcinomas are relatively indolent tumors that develop after prolonged estrogenic stimulation. Low-grade endometrioid adenocarcinoma is the prototype of Type 1 endometrial carcinoma. Although most of these patients do well, recurrence and death due to disease can occur. Type 2 endometrial carcinomas are more aggressive tumors that are not associated with endometrial hyperplasia or estrogen excess. These tumors develop de novo in the atrophic endometrium of older postmenopausal women (4 -7). Papillary serous carcinoma of endometrium (PSCE) is the prototype of Type 2 endometrial carcinoma and is an uncommon aggressive variant of endometrial cancer. It accounts for 1-10% of cas...

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Spontaneous apoptosis in gallbladder carcinoma: Relationships with clinicopathologic factors, expression of E-cadherin,bcl-2 protooncogene, and p53 oncosuppressor gene

Sasatomi

Tokunaga

Miyazaki

1996

Cancer

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Proliferative and Apoptotic Status in Endometrial Adenocarcinoma

Cited by 10 publications

References 0 publications

Cell cycle regulators and apoptosis‐associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma

Cell cycle regulators and apoptosis‐associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma

Markers of Proliferative Activity Are Predictors of Patient Outcome for Low-Grade Endometrioid Adenocarcinoma But Not Papillary Serous Carcinoma of Endometrium

Spontaneous apoptosis in gallbladder carcinoma: Relationships with clinicopathologic factors, expression of E-cadherin,bcl-2 protooncogene, and p53 oncosuppressor gene

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