Proliferative and Malignant Brenner Tumors of the Ovary

Miles, Philip A.; Norris, Henry J.

doi:10.1097/00006254-197302000-00024

Cited by 7 publications

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“…[49][50][51][52] Mucinous elements and, more rarely, mucinous adenocarcinoma may coexist with the transitional component. However, pure mucinous carcinomas associated with a benign Brenner tumor should not be diagnosed as a malignant Brenner tumor.…”

Section: Malignant Brenner Tumor and Transitional Cell Carcinomamentioning

confidence: 99%

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Prat

2005

Mod Pathol

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The differential diagnosis of ovarian carcinomas, including secondary tumors, remains a challenging task. Mucinous carcinomas of the ovary are rare and can be easily confused with metastatic mucinous carcinomas that may present clinically as a primary ovarian tumor. Most of these originate in the gastrointestinal tract and pancreas. International Federation of Gynecology and Obstetrics (FIGO) stage is the single most important prognostic factor, and stage I carcinomas have an excellent prognosis; FIGO stage is largely related to the histologic features of the ovarian tumors. Infiltrative stromal invasion proved to be biologically more aggressive than expansile invasion. Metastatic colon cancer is frequent and often simulates ovarian endometrioid adenocarcinoma. Although immunostains for cytokeratins 7 and 20 can be helpful in the differential diagnosis, they should always be interpreted in the light of all clinical information. Occasionally, endometrioid carcinomas may exhibit a microglandular pattern simulating sex cord-stromal tumors. However, typical endometrioid glands, squamous differentiation, or an adenofibroma component are each present in 75% of these tumors whereas immunostains for calretinin and alpha-inhibin are negative. Endometrioid carcinoma of the ovary is associated in 15-20% of the cases with carcinoma of the endometrium. Most of these tumors have a favorable outcome and they most likely represent independent primary carcinomas arising as a result of a Mü llerian field effect. Although the criteria for distinguishing metastatic from independent primary carcinomas rely mainly upon conventional clinicopathologic findings, loss of heterozygosity and gene mutation analyses can be helpful. Transitional cell carcinomas are distinguished from undifferentiated carcinomas by the presence of thick, undulating papillae with smooth luminal borders, microspaces, and tumor cells with distinctive 'urothelial' appearance. Krukenberg tumors are metastatic adenocarcinomas traditionally perceived as composed of mucin-filled signet-ring cells associated with a striking proliferation of the ovarian stroma but many variations on this pattern occur.

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Section: Malignant Brenner Tumor and Transitional Cell Carcinomamentioning

confidence: 99%

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Prat

2005

Mod Pathol

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“…With these newly refined criteria, most reported cases of malignant Brenner tumor should be considered as However among the 76 cases found in the literature [10,11,, eight were bilateral [15,18,. With the present case included, the incidence of bilaterality is 12% (9 of 77), which is comparable or slightly higher than that reported for benign Brenner tumor.…”

Section: Discussionmentioning

confidence: 49%

Bilateral malignant brenner tumor of the ovary

Chen

1984

Journal of Surgical Oncology

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“…Moreover, histologically confirmed endometrial hyperplasia has been reported in 4-14% of women affected by Brenner tumors (24) and in postmenopausal women this incidence ranged from 7 to 25% (25).…”

Section: Resultsmentioning

confidence: 99%

Brain metastases from malignant Brenner tumor of the ovary: a case report and a literature review

Donato

Donfrancesco

Bracchi

et al. 2016

GIOG

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IntroductionBrenner tumor of the ovary is a relatively uncommon neoplasm. It constitutes about 1.5% of all ovarian tumors and has a predilection for post-menopausal woman, with a peak of incidence in the fifth decade (1-3).These tumors are mainly asymptomatic and in case of small lesions they may be incidentally detected (2). Conversely non pathognomonic clinical symptoms, like pelvic palpable mass or abdominal pain, occur only for larger tumors (1). No screening tests or markers for MBTS exist. Different pathological variants exist: the benign, borderline and malignant types.The vast majority of these neoplasms is benign, while only 1% is malignant. This latter type is often bilateral, constituted by a mixture of solid and cystic tissues, and represents an aggressive form (4) associated with a poor prognosis (5).Diagnosis is made with histological examination and surgery remains the mainstay of treatment (6).Due to the rarity of this malignancy, there are few cases of metastatic MBT described in literature, most including liver and lung metastases (2), dural metastases (7), subcutaneous (8) and cutaneous (9) metastases. Nevertheless non-unanimous consensus is given on which is the best adjuvant treatment (6).Here we present a case of a malignant Brenner tumor of the ovary which metastasized to brain, lung and liver, concomitant with endometroid adenocarcinoma of the uterus in a 46-year-old woman. Materials and methodsA 46-year-old Caucasian woman presented at our emergency room for abnormal uterine bleeding and a Introduction. Brenner tumor of the ovary represents an uncommon neoplasm. It constitutes about 1.5% of all ovarian tumors with a peak of incidence in the fifth decade. The vast majority of Brenner tumors is benign, while only 1% is malignant and associated with a poor prognosis. Diagnosis could be made only with histological examination, and surgery is the mainstay of treatment.Materials and methods. Brain metastases from malignant Brenner tumor of the ovary: a case report and a literature review

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Proliferative and Malignant Brenner Tumors of the Ovary

Cited by 7 publications

References 0 publications

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Ovarian carcinomas, including secondary tumors: diagnostically challenging areas

Bilateral malignant brenner tumor of the ovary

Brain metastases from malignant Brenner tumor of the ovary: a case report and a literature review

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