Proliferative Potentials of Intracranial Chordomas with a Reference to Extracranial Chordomas.

The proliferative potentials of intracranial meningiomas, as represented by bromodeoxyuridine (BrdU) labeling index (LI) and MIB-1 staining index (SI), were examined, and their correlation with recurrence and regrowth of meningiomas was reviewed. The mean BrdU LI of recurrent meningiomas was reported to be significantly higher than that of nonrecurrent meningiomas. BrdU LI can predict the time to re-operation. Many studies have been conducted to examine the relationship between MIB-1 SI and clinical outcome of meningiomas, and most of them showed a significant relationship. Time interval to next recurrence in recurrent meningiomas is associated with MIB-1 SI, and several investigators have shown a cut-off point for MIB-1 SI that can predict future recurrence. BrdU LI, MIB-1 SI, and tumor doubling time of intracranial meningiomas have a mutual relationship. While many other biological or genetic variables can affect the proliferation of tumors, nevertheless BrdU LI and MIB-1 SI are closely correlated with clinical recurrence or regrowth of meningiomas.

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Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry

Matsuno

Nakaguchi

Nagashima

et al. 2005

Acta Histochem. Cytochem

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Proliferative Potentials of Intracranial Chordomas with a Reference to Extracranial Chordomas.

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Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry

Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry

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