Proliferative verrucous leukoplakia and its related lesions

Batsakis, John G.; Suarez, Patricia; El‐Naggar, Adel K.

doi:10.1016/s1368-8375(99)00007-x

Cited by 154 publications

(126 citation statements)

References 19 publications

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“…Hematoxylin and eosin stained slides from the resection specimens, as well as any prior biopsy specimens, were reviewed for classification. Patients meeting criteria for proliferative verrucous leukoplakia (based on clinical and pathologic features described in the literature) were excluded [11,12]. Treatment and follow up information were gathered from the electronic medical The following criteria were used to classify tumors into Categories A, B, or C. Category A were pure VC cases showing the characteristic histopathologic features, such as thick, inward growing ribbons and nests with large epithelial cells having abundant glassy, eosinophilic cytoplasm, hyperkeratosis, broad pushing rete with or without chronic inflammation at the epithelial-stromal junction, and smooth stromal interface (Fig.…”

Section: Methodsmentioning

confidence: 99%

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Patel

Chernock

Sinha

et al. 2014

Head and Neck Pathol

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Verrucous carcinomas (VC) recur locally but do not metastasize in the absence of an invasive squamous cell carcinoma (SCC) component. Although excluded from the definition of pure VC, some tumors harbor only dysplasia or minimal invasion, findings of unknown clinical significance. Surgically resected VC cases from two institutions were collected and categorized into three types: VC, VC with dysplasia or minimal invasion (VCDMI), defined as SCC less than or equal to 2 mm in depth, and SCC arising in VC (SCC-VC) where the SCC was greater than 2 mm in depth. Cases were also matched with conventional SCC based on location and T and N-stages, and clinical follow up was obtained. Of the 58 total cases, 18 were VC, 26 VCDMI, and 14 SCC-VC. Only 1 of 18 (5.6 %) VC and 5 of 26 (19.2 %) VCDMI cases recurred locally (p = 0.37) versus 7 of 14 (50 %) SCC-VC (p = 0.01). All VC and VCDMI cases were node negative at presentation whereas SCC-VC had nodal metastases in 2 of 14 (14.3 %) cases. No patients with VC or VCDMI died from disease, whereas 5 of 14 (35.7 %) patients with SCC-VC died from disease. T-stage matched conventional SCC cases from institutional databases had worse outcomes than VC and VCDMI, but not after they were matched for both T and N-stages. Our findings suggest that dysplasia and/or minimal invasive SCC do not adversely affect outcomes in tumors otherwise showing diagnostic features of VC.

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Section: Methodsmentioning

confidence: 99%

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Patel

Chernock

Sinha

et al. 2014

Head and Neck Pathol

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“…Any given lesion may show a combination of verrucous hyperplasia, VC, and conventional welldifferentiated SCC. Given the fact that PVL is associated with VC in a high percentage of cases, some authors believe that PVL should be considered to be a premalignant condition or an early biologic form of VC (51,53). This would then obviate the confusion, both clinically and pathologically, that surrounds the use of the term verrucous hyperplasia in describing these oral cavity lesions.…”

Section: Differential Diagnosismentioning

confidence: 99%

Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants

Wenig

2002

Modern Pathology

120

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“…The clinical appearance of non-homogeneous or speckled OL may correlate with the likelihood that the lesion will show epithelial changes or malignant transformation. In a study by Silverman and co-workers, the overall malignant Table 1 Modified review of Izumo [14] presenting six classifications of oral and laryngeal precursor lesions [2,7,[15][16][17] WHO-DC World Health Organization dysplasia system; CIS carcinoma in situ; SIN squamous intraepithelial neoplasia; LC Ljubljana classification; SIL squamous intraepithelial lesions; OIN oral intraepithelial neoplasia; OED oral epithelial dysplasia; JSOP Japanese Society for Oral Pathology [22]. Compared to OL, oral erythroplakia has significantly worse biological behavior, with up to 50 % of malignant transformation [23].…”

Section: Oral Cavitymentioning

confidence: 99%

Current Views and Perspectives on Classification of Squamous Intraepithelial Lesions of the Head and Neck

Gale

Zidar

Poljak

et al. 2014

Head and Neck Pathol

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The current state in the field of classifying oral and laryngeal precursor lesions, as proposed in the WHO 2005 Blue Book is not ideal. The results of various interobserver studies have shown that the currently used grading systems, with different basic concepts and different terminology, cannot continue to be reliably used in the future. The different etiology of cervical and head and neck precursor lesions requires a classification designed to cater to the specificities of the head and neck region. Trying to harmonize different classifications of the oral and laryngeal precursor lesions, we have proposed four crucial steps to set up a unified classification of squamous intraepithelial lesions (SILs): (a) the classification should contain two grades, low-grade and high-grade lesions and, specifically for the larynx, an additional grade-carcinoma in situ (CIS) which must be separated from high-grade laryngeal SILs; (b) the terminology should be unified; our preference is for the term SIL over squamous intraepithelial neoplasia; (c) all leading morphological criteria for low-and highgrade lesions, as well as for CIS, should be clearly defined; (d) agreement between clinicians and pathologists should be achieved on the most appropriate choice of treatment of different grades of SILs in separate head and neck areas.

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Proliferative verrucous leukoplakia and its related lesions

Cited by 154 publications

References 19 publications

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants

Current Views and Perspectives on Classification of Squamous Intraepithelial Lesions of the Head and Neck

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