Proliferative Verrucous Leukoplakia and Verrucous Carcinoma –A Diagnostic Dilemma - Case Report

Reddy, G Vivekanandh

doi:10.5368/aedj.2010.2.4.52-55.pdf

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…7 More recently,studies have confirmed the association between Human papilloma virus(HPV) and verrucous carcinoma by detecting HPV-DNA types 6,11,16 and 18 by polymerase chain reaction,restriction fragment analysis and DNA slot-blot Hybridization. 13 Verrucous carcinoma presents predominantly as an exophytic growth with a pebbly,micronodularsurface,a slow growing rate,and becomes locally invasive if not treated properly. 2 It is a unique clinicopathological variant of squamous cell carcinoma,occuring mainly in oral cavity and larynx,buccal mucosa being most commonly involved.It is a very rare entity first described by Ackerman in 1948.Various synonyms are used to describe this tumour,including Ackerman's tumour,BuschkeLoewensteintumour,florid oral papillomatosis,epitheliomacuniculatum,and carcinoma cuniculatum.…”

Section: Discussion:-mentioning

confidence: 99%

“…15 Multiple deep biopsies are recommended to avoid the problem of underdiagnosis. 13 With the knowledge of risk factors,primary prevention through the elimination of tobacco consumption,the moderation of alcohol intake and chemoprevention is urgently needed.Research on the natural history of the disease,particularly which precancers will progress over time,would help to develop screening programmes tailored more to the individual disorders.Development of tumour markers with high sensitivity and specificity could assist the detection of patients and lesions at risk. 14 Because metastases is an extremely rare event in verrucouscarcinoma,the treatment of choice is surgical excision without radical neck dissection.Recently successful treatment of an extensive verrucous carcinoma with intra-arterial infusion of methotrexate or topical 5aminolevulinic acid mediated photodyanamic therapy was reported.…”

Section: Discussion:-mentioning

confidence: 99%

“…14 Because metastases is an extremely rare event in verrucouscarcinoma,the treatment of choice is surgical excision without radical neck dissection.Recently successful treatment of an extensive verrucous carcinoma with intra-arterial infusion of methotrexate or topical 5aminolevulinic acid mediated photodyanamic therapy was reported. 13 Because of reported incidence of anaplastic transformation following radiotherapy,manycentres recommend wide field surgical resection with good oncoclearance as preferred treatment modality. 12 The use of buccal fat pad has increased in popularity because of its reliability,ease of harvest,and low complication rate.It has been used as a pedicle or free graft in reconstructing small to medium sized defects intraorally.…”

Section: Discussion:-mentioning

confidence: 99%

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Verrucous Carcinoma of Buccal Mucosa: A Case Report and Review.

Kohli¹

2019

IJAR

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Verrucous carcinoma is a lesion with minimum aggressive potential. It is a variant of squamous cell carcinoma. It most commonly affects oral cavity with buccal mucosa being the commonest site affected. 1 It presents predominantly as an exophytic growth with a pebbly micronodular surface and a slow growing rate. 2 The anatomy of buccal mucosa and buccal space allows for extension of carcinoma unimpeded by any anatomic barriers to neighbouring intraoral subsites and structures. 3 Tobacco,alcohol and opportunist viral infections are the most associated etiologies with verrucous carcinoma. 1 Ackerman first recognised this lesion as a distinct entity in 1948, so it is also known as ACKERMAN'S TUMOUR. 5 The diagnosis in verrucous lesions of the oral cavity can range from verrucous hyperplasia to verrucous proliferative leukoplakia and verrucous carcinoma. 6 Case report: A 48 year old male patient reported with a chief complain of assymetry on the left side of face since 3 months (Figure 1 a,b). He initially observed ulceration on the inner side of left cheek but did not took any medication for the same. He also observed extraoral swelling on left side of face which gradually increased in size. He developed pain 3 months back which was initially mild and intermittent but has aggrevated since 7 days. He has a history of chewing supari since 40 years,15 times a day in lower left buccal vestibule for 5 minutes following which he used to spit out contents. He is suffering from mild bronchitis and mild cardiomegaly, according to diagnostic reports of a government hospital. There was no relevant family history. On general examination, he had normal gait and posture and was well oriented, consious and moderatly built. No evidence of pallor, icterus, cyanosis and clubbing was present. Single left submandibular lymph node was palpable of approximately 1cm by 1cm in size, ovoid in shape, non-tender, fixed on palpation and firm in consistency. During intraoral examination,oninspection,there was presence of solitary proliferative verrucous growth on left buccal mucosa extending anteroposteriorly in relation to mesial side of 34 uptoretromolar area and superioinferiorly from level of occlusal plane upto depth of buccal vestibule in relation to 34,35,36,37.The lesion was approximately 30mm by 20mm in size,well-defined with irregular margins.The lesion appeared exophytic and cauliflower shaped (Figure 2).Surface of the lesion was irregular with rough consistency and colour of the lesion varied from pink in periphery to white in the centre.Onpalpation,inspectory findings of size,site,surface and shape were confirmed.The lesion was non-scrappable,non-tender,andindurated.There was no bleeding on touching.Hard tissue examination

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Section: Discussion:-mentioning

confidence: 99%

Section: Discussion:-mentioning

confidence: 99%

Section: Discussion:-mentioning

confidence: 99%

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Verrucous Carcinoma of Buccal Mucosa: A Case Report and Review.

Kohli¹

2019

IJAR

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“…25 Yoshimura &Vivekanando et al, also recorded the similar presentation of OVC in their study. 36,40 OVC present both benign and malignant processes, malignant ovc contain small foci of squamous cell carcinoma, which are known as a "hybrid" forms of verrucouscarcinoma. 9 Generally speaking, the accurate histological classification of squamous mucosal lesions with an exophytic growth pattern is often difficult and requires experience.…”

Section: Resultsmentioning

confidence: 99%

Varied Presentation of Oral Verrucous Carcinoma in a Tertiary Hospital of Dhaka City

Mamun¹,

Rahman²,

Haider

et al. 2021

J. Bangladesh Coll. Phys.

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Introduction: Ackerman’s tumor or Verrucous carcinoma is a distinguished clinic-pathological variant of squamous cell carcinoma, presenting with multiple clinical presentations. This study provides a contemporary survey of morphological presentation of oral verrucous carcinoma (OVC) in the oral cavity with site of predilection and possible etiological factors. Method: An observational studywas conducted from January 2014 to June 2016.A suspected patient diagnosed clinically and histologically as OVC at the Dhaka Dental College Hospital (DDCH) was enrolled in this study. Results: In this study total 15 number of patients male were 53.3% and female were 47%. The morphological presentation of the study was proliferative and verrucous, each of which comprises 40.0% of cases. The tumor's primary site was the buccal mucosa 46.67% and history ofbetel quid chewing was 46.9%. Conclusion: The study concluded that it is very difficult to distinguishing clinically between verrucous carcinoma and other exophytic lesions of the oral cavity. OVC presents with different morphological presentation such as proliferative and verrucous types. Buccal mucosa is the site of predilection. J Bangladesh Coll Phys Surg 2021; 39(2): 80-86

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Proliferative Verrucous Leukoplakia and Verrucous Carcinoma –A Diagnostic Dilemma - Case Report

Cited by 2 publications

References 5 publications

Verrucous Carcinoma of Buccal Mucosa: A Case Report and Review.

Verrucous Carcinoma of Buccal Mucosa: A Case Report and Review.

Varied Presentation of Oral Verrucous Carcinoma in a Tertiary Hospital of Dhaka City

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