Proliferative vitreoretinopathy as a late complication of blunt ocular trauma

Waters, Tilena; Vollmer, Lori; Sowka, Joseph

doi:10.1016/j.optm.2007.09.016

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…PVR has been confirmed to be a common complication of severe ocular trauma or inflammatory retinopathy [ 26 , 27 ]. At present, PVR is considered to be an excessive injury repair reaction occurring in the eye, but the exact mechanism of its formation is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4

Dong

Wang

2021

Bioengineered

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Exosomal microRNAs (miRNAs) have been shown to be involved in the regulation of many disease progression, including proliferative vitreoretinopathy (PVR). However, the roles of exosomal miR-4488 and miR-1273g-5p in PVR progression have not been demonstrated. Transforming growth factor β2 (TGF-β2)-induced ARPE-19 cells were used to stimulate the epithelial-mesenchymal transition (EMT) of cells.Exosomes derived from TGF-β2-induced ARPE-19 cells were identified by transmission electron microscopy and nanoparticle tracking analysis. The expression levels of miR-4488, miR-1273g-5p and ATP-binding cassette A4 (ABCA4) were measured by quantitative real-time PCR. The promotion levels of exosomes markers, EMT markers, apoptosis markers and ABCA4 were determined by western blot analysis. The migration, invasion and apoptosis of cells were determined by transwell assay, wound healing assay and flow cytometry. Our data showed that miR-4488 and miR-1273g-5p were lowly expressed in TGF-β2-induced ARPE-19 cells.Overexpressed exosomal miR-4488 and miR-1273g-5p could inhibit the EMT, migration, invasion, and promote apoptosis in TGF-β2-induced ARPE-19 cells. In addition, ABCA4 was a target of miR-4488 and miR-1273g-5p. Overexpressed ABCA4 also could reverse the negatively regulation of exosomal miR-4488 and miR-1273g-5p on the EMT, migration, and invasion of TGF-β2-induced ARPE-19 cells. In conclusion, our data showed that exosomal miR-4488 and miR-1273g-5p could inhibit TGF-β2-stimulated EMT in ARPE-19 cells through targeting ABCA4.

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Section: Discussionmentioning

confidence: 99%

Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4

Dong

Wang

2021

Bioengineered

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“…A case of delayed PVR has been reported in a case of severe penetrating ocular trauma occurring after five years. The patient had a history of scleral laceration with uveal prolapse which had not been previously treated (4). The reason for the rarity of late onset PVR is proliferation of the cells is related to a stimulus and is unlikely to start without a cause or precipitant (2).…”

Section: Discussionmentioning

confidence: 99%

Late Retinal Redetachment Due to Proliferative Vitreoretinopathy after More Than One Decade

Norlelawati¹,

Bastion²

2016

JSA

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A 44-year-old Malay lady presented with recent onset of inferior field defect for a week. Vision was 6/18, N18. She gave a history of myopia and two prior retinal detachment surgeries twelve years previously following which the retina was flat. Subsequently, the vision reduced to hand motions as the macula became involved. She then underwent successful re-attachment vitrectomy surgery for rhegmatogenous retinal detachment due to superior retinal breaks in association with proliferative vitreoretinopathy (PVR) Grade B. We share this interesting case of retinal redetachment in a previously vitrectomised eye that was stable during follow up for more than 10 years. This was associated with late onset PVR. Counselling of patients on the symptoms of redetachment due to late onset PVR is mandatory in patients after retinal detachment surgery.

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“…Eye injury if occurred in closed eye, causes contusion or lamellar laceration and if that happens in an open eye, then it can lead to rupture, perforation or penetrating injury to the eyeball. Eye injury if occurred in closed eye, causes contusion or lamellar laceration and if that happens in an open eye, then it can lead to rupture, perforation or penetrating injury to the eyeball [2]. Trauma to eyes is main cause of ocular morbidity which can be avoided by simple measures.…”

Section: Pathophysiologymentioning

confidence: 99%

Ocular Trauma in Pediatric Population

Jadhav

Sohrot

Lohiya

2021

JPRI

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Pediatric ocular trauma is the main challenge for ophthalmologists. It is the most crucial cause of monocular blindness. Thus, it is the main problem in public health management. This study is aimed to determine the clinical characteristics and visual consequences of ocular trauma. The ocular trauma with further complications can result in blindness. An immediate evaluation of the potential damage may be impossible because of vitreous hemorrhage or may be ill-advised because of hyphema or damage to other ocular or orbital structures. Books like Comprehensive Ophthalmology by Dr. A K Khurana and various articles, WHO (World Health Organization) website, etcetera were referred for this review article. Trauma in pediatric age groups is more prevalent than that in adult age groups. The so, the male gender is more prone to such injuri females. This study concludes that trauma to eyes the is the leather dying cause of ocular morbidity, which can be avoided by simple measures. First aid and early treatment can cause a significant decrease in loss of vision due to ocular trauma. Thus, a little awareness in parents and guardians can help decrease loss and blindness in the pediatric population. Eye injury, if occurred in a closed eye, causes contusion or lamellar laceration, and if that happens in an open eye, then it can lead to rupture, perforation, or penetrating injury to the eyeball. Troma to the eyes is the leading cause of ocular morbidity, which simple measures can avoid. First aid and early treatment can cause significant decrease in loss of vision due to ocular trauma. Thus, a little awareness in parents and guardians can help decrease loss and blindness in the pediatric population.

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Proliferative vitreoretinopathy as a late complication of blunt ocular trauma

Cited by 6 publications

References 19 publications

Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4

Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting ATP-binding cassette A4

Late Retinal Redetachment Due to Proliferative Vitreoretinopathy after More Than One Decade

Ocular Trauma in Pediatric Population

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