Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer

Granja, Fabiana; Morari, Joseane; Morari, Elaine Cristina; Correa, Luiz Artur Costa; Assumpção, Lígia Vera Montali da; Ward, Laura Sterian

doi:10.1016/j.canlet.2004.01.016

Cited by 94 publications

(94 citation statements)

References 24 publications

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“…In other studies, however, authors have found the opposite correlation, instead demonstrating an association between the P72 (lesser apoptotic) variant and increased risk for other cancer types, including cancer of the thyroid (Granja et al, 2004), nasopharynx (Tsai et al, 2002a, b;Tiwawech et al, 2003), prostate (Suzuki et al, 2003), skin (Chen et al, 2003), urogenital region (Kuroda et al, 2003), and lung Fan et al, 2000;Zhang et al, 2003). Still other groups have failed to demonstrate any association between codon 72 variants of p53 and cancer risk.…”

Section: The Codon 72 Polymorphismmentioning

confidence: 95%

Polymorphisms in the p53 pathway

2006

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Section: The Codon 72 Polymorphismmentioning

confidence: 95%

Polymorphisms in the p53 pathway

2006

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“…These studies have come to very varied conclusions, with some studies reporting increased risk associated with the P72 allele for certain cancer types [19][20][21] and others failing to reach such conclusions. [22][23][24] The reasons for these discrepancies are not clear, but it can be safely said that if such associations exist, they may not be particularly strong, or they be influenced by unknown variables that presently are not controlled for in such studies.…”

Section: Impact Of the Codon 72 Polymorphism On Cancer Risk Progressmentioning

confidence: 99%

Polymorphic variants in the p53 pathway

Murphy

2006

Cell Death Differ

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“…Data on the TP53 and XRCC3 polymorphisms associations are quite limited (Hillebrandt et al 1997, Boltze et al 2002, Granja et al 2004, Sturgis et al 2005, Rogounovitch et al 2006. Therefore, in this study, we addressed the relation of SNPs in aforementioned DNA damage response genes to the risk of PTCs of different etiology.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma

Akulevich¹,

Saenko²,

Rogounovitch³

et al. 2009

Endocrine-Related Cancer

121

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Papillary thyroid carcinoma (PTC) etiologically occurs as a radiation-induced or sporadic malignancy. Genetic factors contributing to the susceptibility to either form remain unknown. In this retrospective case-control study, we evaluated possible associations between singlenucleotide polymorphisms (SNPs) in the candidate DNA damage response genes (ATM, XRCC1, TP53, XRCC3, MTF1) and risk of radiation-induced and sporadic PTC. A total of 255 PTC cases (123 Chernobyl radiation-induced and 132 sporadic, all in Caucasians) and 596 healthy controls (198 residents of Chernobyl areas and 398 subjects without history of radiation exposure, all Caucasians) were genotyped. The risk of PTC and SNPs interactions with radiation exposure were assessed by logistic regressions. The ATM G5557A and XRCC1 Arg399Gln polymorphisms, regardless of radiation exposure, associated with a decreased risk of PTC according to the multiplicative and dominant models of inheritance (odds ratio (OR)Z0.69, 95% confidence interval (CI) 0.45-0.86 and ORZ0.70, 95% CI 0.59-0.93 respectively). The ATM IVS22-77 TOC and TP53 Arg72Pro SNPs interacted with radiation (PZ0.04 and PZ0.01 respectively). ATM IVS22-77 associated with the increased risk of sporadic PTC (ORZ1.84, 95% CI 1.10-3.24) whereas TP53 Arg72Pro correlated with the higher risk of radiogenic PTC (ORZ1.80, 95% CI 1.06-2.36). In the analyses of ATM/TP53 (rs1801516/rs664677/rs609429/rs1042522) combinations, the GG/TC/CG/GC genotype strongly associated with radiation-induced PTC (ORZ2.10, 95% CI 1.17-3.78). The GG/CC/GG/GG genotype displayed a significantly increased risk for sporadic PTC (ORZ3.32, 95% CI 1.57-6.99). The results indicate that polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs.

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Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer

Cited by 94 publications

References 24 publications

Polymorphisms in the p53 pathway

Polymorphisms in the p53 pathway

Polymorphic variants in the p53 pathway

Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma

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