Proline in fascioliasis—IV induction of bile duct hyperplasia

Sawma, Joseph T.; Isseroff, Hadar; Reino, David

doi:10.1016/0300-9629(78)90104-4

Cited by 14 publications

(1 citation statement)

References 22 publications

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“…The origin of the increased amounts of amino acids is not clear, but Kuralec & Rijavec (1966) found that adult liver flukes contained particularly high concentrations of proline, and it is possible that once in the bile duct the flukes themselves could be the source of some of the increases in amino acids. Isseroff, Sawma & Reino (1977) and Sawma, Isseroff & Reino (1978) found that prolonged injection of proline into the abdominal cavity and bile duct respectively, of rats produced slight biliary hyperplasia and further that the use of the proline analogue, azetidine by Girotra & Isseroff (1980) was shown to inhibit the biliary hyperplasia in rats infected with F. hepatica.…”

Section: Discussionmentioning

confidence: 99%

A study of the initiation of biliary hyperplasia in rats infected with Fasciola hepatica

Foster

1981

Parasitology

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SUMMARYFollowing infection of rats with Fasciola hepatica, an increase in the number of epithelial cells in the common bile duct, labelled with [3H]thymidine, was detected autoradiographically as early as 5 days post-infection (p.i.). This initial mitogenic effect of the infection was limited to that region of the bile duct lying adjacent to the liver, while the region lying next to the duodenum failed to show any increase in labelling until 41 days p.i. Mechanical contact between the parasite and the biliary epithelium did not occur until 41 days p.i. and the initial hyperplasia was evidently not a result of mechanical irritation. The study serves to emphasize the chemical aetiology of the precocious biliary hyperplasia and to more accurately identify its onset.

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Section: Discussionmentioning

confidence: 99%

A study of the initiation of biliary hyperplasia in rats infected with Fasciola hepatica

Foster

1981

Parasitology

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Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine‐initiated hamster livers

Thamavit

Pairojkul

Tiwawech

et al. 1994

Teratog Carcinog Mutagen

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Bile duct hyperplasia caused by proline is believed to represent a chemical effect of the liver fluke, Fasciola hepatica, and the resultant cell division might be expected to play a role as a tumor promoter. To investigate the potential promoting effect of proline on bile duct cancer development, Syrian hamsters were therefore divided into 8 treatment groups: dimethylnitrosamine (DMN) + proline intraperitoneally (i.p.); DMN + proline s.c.; DMN + saline i.p.; DMN + saline s.c.; proline i.p.; proline s.c.; saline i.p.; and saline s.c. DMN was injected i.p. at 20 mg/kg to the animals 2 weeks prior to commencement of proline treatment, whereby 1 ml of a 2 M solution was given by i.p. or s.c. injection 3 times a week for 20 weeks. At the end of week 42, assessment of preneoplastic lesion development did not reveal any significant modulating influence of proline on DMN-initiated lesion development nor did it itself cause persistent bile duct hyperplasia.

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Hepatic proline after bile duct ligation in rats

1983

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Since biliary hyperplasia of fascioliasis correlated with hepatic proline level, we examined the occurrence of a similar chemical stimulus during bile obstruction. Uptake of tritiated proline and glycine rose in both hepatocytes and a bile duct enriched cell fraction, following duct ligation in rats. The increased hepatic content of proline but not glycine suggests that proline has a role in post-obstructive biliary proliferation.

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Proline in fascioliasis—IV induction of bile duct hyperplasia

Cited by 14 publications

References 22 publications

A study of the initiation of biliary hyperplasia in rats infected with Fasciola hepatica

A study of the initiation of biliary hyperplasia in rats infected with Fasciola hepatica

Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine‐initiated hamster livers

Hepatic proline after bile duct ligation in rats

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