Proliposomes as Pharmaceutical Drug Delivery System: A Brief Review

Muneer, Saiqa; Masood, Z; S, Butt; Anjum, Sadiya; Zainab, H; Anwar, Naveed; Ahmad, Naveed

doi:10.4172/2157-7439.1000448

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…Do tồn tại ở trạng thái rắn nên hầu hết các vấn đề về độ ổn định của liposome được giải quyết và dễ dàng ứng dụng được vào các dạng thuốc rắn. Proliposome có thể được bào chế bằng các phương pháp khác nhau như hydrat hóa màng film, phun sấy, phương pháp đối kháng dung môi siêu tới hạn, phương pháp bao hạt,… [4,5]. Trong nghiên cứu trước, nhóm tác giả đã nghiên cứu bào chế liposome BBR sử dụng các thành phần phosphatidyl choline đậu nành hydrogen hóa (HSPC), natri deoxycholat (NaDC) và vitamin E bằng phương pháp tiêm ethanol [6].…”

Section: Mở đầU *unclassified

Formulation of Spray-dried Proliposomes Loaded with Berberin

Yen

Quynh²,

Thuan³

et al. 2021

MPS

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The aims of study was formulation and evaluation of berberin (BBR) loaded proliposomes by spray-drying method. BBR proliposomes were evaluated for appearance, spray-drying efficiency, morphology and differential scanning calorimetry (DSC). Liposomes, obtained after hydration, were evaluated for particle size, size distribution, morphology and entrapment efficiency. The results showed that BBR proliposomes were prepared by spray-drying method with molar ratio of Hydrogenated soy phosphatidyl choline (HSPC): Sodium deoxycholat (NaDC): vitamin E (vtE): BBR = 7: 1: 6: 6. Mixture of manitol and Aerosil at weight ratio of 97:3 was used as carrier. Results of DSC showed that berberin was dispersed molecularly into proliposomes powder. BBR liposomes, obtained after hydration, had average particle diameter of about 29 μm and entrapment efficiency was 22.23%. Keywords Proliposomes, liposomes, berberin, sodium deoxycholate, spray-dried. References [1] W. Kong, J. Wei, A. Parrveen et al., Berberine is A Novel Cholesterol-Lowering Drug Working Through A Unique Mechanism Distinct From Statins, Nature Medicine, Vol. 10, No. 12, 2004, pp. 1344-1351, https://doi.org/10.1038/nm1135.[2] S. K. Kulkarni, A. Dhir, on The Mechanism of Antidepressant-Like Action of Berberine Chloride, European Journal of Pharmacology, Vol. 589, No. 1-3, 2008, pp. 163-172, https://doi.org/ 10.1016/j.ejphar.2008.05.043.[3] Y. T. Ho, J. S. Yang, T. C. Li et al., Berberine Suppresses in Vitro Migration and Invasion of Human SCC-4 Tongue Squamous Cancer Cells Through the Inhibitions of FAK, IKK, NF-Κb, U-PA and MMP-2 and-9, Cancer Letters, Vol. 279, No. 2, 2009, pp. 155-162, https://doi.org/10.1016/j.canlet.2009.01.033.[4] S. Muneer, Z. Masood, S. Butt et al., Proliposomes as Pharmaceutical Drug Delivery System: A Brief Review, Journal of Nanomedicine and Nanotechnology, Vol. 8, No. 3, 2017, pp. 448-450, https://doi.org/10.4172/2157-7439.1000448.[5] H. K. Omer, N. R. Hussein, A. Ferraz et al., Spray-Dried Proliposome Microparticles for High-Performance Aerosol Delivery Using a Monodose Powder Inhaler, AAPS PharmSciTech, Vol. 19, No. 5, 2018, pp. 2434-2448, https://doi.org/10.1208/s12249-018-1058-4.[6] T. T. H. Yen, T. T. N. Quynh, D. T. Thuan, P. T. M. Hue, Preparation of Berberin Liposomes, Contained Sodium Deoxycholate by Ethanol Injection Method, Journal of Pharmaceutical Research and Drug information, Vol. 11, No. 4, 2020, pp. 11-17 (in Vietnamese). [7] T. T. H. Yen, T. T. Hue, P. T. M. Hue et al., Preparation of Berberin Proliposomes by Film Deposition on Carrier Surface Method, VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 36, No. 2, 2020, pp. 9-15, https://doi.org/10.25073/2588-1132/vnumps.4204.[8] R. G. Ahmed, S. Sherif, Z. Zainab et al., Silymarin Spray-Dried Proliposomes: Preparation, Characterization and Cytotoxic Evaluation, Drug Delivery Letters, Vol. 10, No. 1, 2020, pp. 14-23, https://doi.org/10.2174/2210303109666190722114211.[9] A. Bangham, M. M. Standish, J. C. Watkins Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids, Journal of Molecular Biology, Vol. 13, No. 1, 1965, pp. 238-252.

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Section: Mở đầU *unclassified

Formulation of Spray-dried Proliposomes Loaded with Berberin

Yen

Quynh²,

Thuan³

et al. 2021

MPS

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“…20 Liposomes also suffer from being relatively unstable colloidal systems. 21 Both, the high costs and stability concerns of liposomes were solved by the introduction of the concept of proliposomes. Proliposomes are completely dry, free-flowing powders made of lipid vesicles engulfing the drug in question within its bilayer structure.…”

Section: Introductionmentioning

confidence: 99%

“…13 Being in dry powder form, proliposomes facilitate product transfer and storage which lowers costs needed otherwise. 21 Proliposomes undergo a rapid and easy hydration step, under controlled conditions of temperature and agitation, to turn into liposomes. Within the aqueous environment of the lungs, proliposomes are easily hydrated and exert their action locally or, if needed, rapidly absorbed and enters the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin

Adel

ElMeligy

Abdelrahim

et al. 2021

IJN

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Purpose The goal was to directly deliver curcumin, a natural polyphenolic anticancer and anti-inflammatory compound, to the lung tissues with minimal systemic exposure through the fabrication of proliposomes, overcoming its poor aqueous solubility and oral bioavailability. Methods Nano-spray drying was employed to prepare proliposomes using hydroxypropyl beta-cyclodextrin as a carrier. Lecithin and cholesterol were used as lipids, stearylamine and Poloxamer 188 were added as positive charge inducer and a surfactant, respectively. Different characterization parameters were evaluated like percentage yield, entrapment efficiency, drug loading, aerodynamic particle size, in vitro release besides morphological examination. Cytotoxicity studies on cell line A549 lung tumor cells as well as in vivo lung pharmacokinetic studies were also carried. Results The optimized formulations showed superior aerosolization properties coupled their enhanced ability to reach deep lung tissues with a high % of fine particle fraction. Cytotoxicity studies using MTT assay demonstrated enhanced growth inhibitory effect on lung tumor cells A549 and significant reduction of proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6 and interleukin-10 compared to the pure drug. Results of lung pharmacokinetic tests confirmed the superiority of proliposomal curcumin over curcumin powder in both, the rate and extent of lung tissue absorption, as well as the mean residence time within the lung tissues. Conclusion The pulmonary delivery of curcumin-loaded proliposomes as dry powder provides a direct approach to lung tissues targeting while avoiding the limitations of the oral route and offering a non-invasive alternative to the parenteral one.

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“…First of all, variable polarity compounds can be entrapped simultaneously to the liposome system. Although the hydrophilic core provides a suitable environment for polar compounds, the liposome wall lipid composition can be exploited to encapsulate more lipophilic polyphenol compounds (29). Secondly, this encapsulation approach can provide protection for bioactive components and increase their solubility and functionality (29,30).…”

Section: Introductionmentioning

confidence: 99%

“…Although the hydrophilic core provides a suitable environment for polar compounds, the liposome wall lipid composition can be exploited to encapsulate more lipophilic polyphenol compounds (29). Secondly, this encapsulation approach can provide protection for bioactive components and increase their solubility and functionality (29,30). These characteristics are particularly desirable for polyphenols that have high radical oxygen scavenging properties, a characteristic that is unfortunately also linked to their lack of long-term stability (14,16).…”

Section: Introductionmentioning

confidence: 99%

Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols

et al. 2020

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This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2 3 Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (X p); water activity (A w); concentration and retention of rosemary polyphenols-rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH •) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with X p and A w of 1.7 ± 0.14-2.5 ± 0.23% w/w and 0.30 ± 0.004-0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC 50 of 9.2 ± 0.2 μg/ mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against Candida albicans (ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.

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Proliposomes as Pharmaceutical Drug Delivery System: A Brief Review

Cited by 11 publications

References 23 publications

Formulation of Spray-dried Proliposomes Loaded with Berberin

Formulation of Spray-dried Proliposomes Loaded with Berberin

Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin

Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols

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