Prolongation and optimization of Doppler enhancement with a microbubble US contrast agent by using continuous infusion: preliminary experience.

Albrecht, Thomas; Urbank, A.; Mahler, Marianne; Bauer, André; Doré, Caroline J; Blomley, Martin; Cosgrove, David O.; Schlief, Reinhard

doi:10.1148/radiology.207.2.9577478

Cited by 136 publications

(72 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intravenous injection of an ultrasound contrast agent (USCA) that is not eliminated via the lungs (eg, Levovist) considerably improves the quality of the Doppler signal even if penetration of the temporal bone is poor. [5][6][7][8][9][10] Therefore, it seemed to be logical to perform the TCD-CO 2 test with such an agent. The effect of a single-bolus injection is only of short duration.…”

mentioning

confidence: 99%

“…This can be achieved through a continuous injection with an infusion pump. 6,12 However, the question of whether the use of echoenhancing contrast agents leads to an increase in the velocity determined by Doppler ultrasound is controversial in the literature. Although Melany et al 13 came to the conclusion that USCAs do not significantly influence the measured velocity, Forsberg et al 14 and Fürst et al 15 described an increase of 20% to 45% in the maximum Doppler shift.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO ₂ Test Using an Ultrasound Contrast Agent (Levovist)

Rohrberg

Brodhun

2001

Stroke

View full text Add to dashboard Cite

Background and Purpose-Determination of vasomotor reserve (VMR) with the transcranial Doppler-CO 2 test is used to assess the risk of impending cerebral ischemia in patients with high-grade stenosis or occlusion of the internal carotid artery. In patients with a poor temporal window, however, this examination is limited. The aim of this study therefore was to examine whether the use of an ultrasound contrast agent (USCA) influences the results of the TCD-CO 2 test. Methods-In the first part of the study, 6 control subjects and 20 patients were examined with the TCD-CO 2 test. The VMR was determined first without the application of a contrast agent and then with continuous infusion of an USCA (Levovist, 300 mg/mL, 1 mL/min). In the second part of the study, 2 tests without USCA were performed in each of 13 patients and 2 tests with USCA infusion were performed in each of 12 patients. Statistical analysis included differences between the VMR determined with the 2 comparative measurements (⌬VMR), the mean (M⌬ VMR ), and SD. Results-Based on the mean difference, the TCD-CO 2 test produced the same results with and without USCA (M⌬ VMR 1.8%), although the differences showed a wide distribution (2 SDs, Ϯ20.7%). Similar spreads were seen in repeated determinations of VMR in the same patient without USCA (2 SDs, Ϯ20.0%), whereas the distribution under continuous USCA infusion was considerably smaller (2 SDs, Ϯ8.2%). Conclusions-The TCD-CO 2 test can be performed with continuous infusion of an USCA without influencing the results.Even with a good temporal window, the results of the TCD-CO 2 test show better reproducibility and thus better reliability if an USCA is used.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO ₂ Test Using an Ultrasound Contrast Agent (Levovist)

Rohrberg

Brodhun

2001

Stroke

View full text Add to dashboard Cite

show abstract

“…Levovist was applied at concentrations of 400 mg/ml using either intravenous bolus injection [28, 29]or continuous infusion by means of a pump [32, 33]. No TCCS study has compared both methods of Levovist application, but preliminary experience obtained in peripheral arteries suggest that the use of an infusion pump may avoid color blooming and reduce spectral bubble noise and the need to alter Doppler system settings [34]. …”

Section: Ucasmentioning

confidence: 99%

Transcranial Color Duplex Sonography in Cerebrovascular Disease: A Systematic Review

Baumgartner

2003

Cerebrovasc Dis

View full text Add to dashboard Cite

Transcranial color-coded duplex sonography (TCCS) enables the reliable assessment of intracranial stenoses (sensitivity 94–100%, specificity 99–100%), occlusions (middle cerebral artery: sensitivity 93–100%, specificity 98–100%) and cross-flow through the anterior (sensitivity 98%, specificity 100%) and posterior (sensitivity 84%, specificity 94%) communicating arteries without using potentially dangerous compression tests, as well as the midline shift in hemispheric infarcts. Ultrasound contrast agents (UCAs) increase the number of conclusive TCCS studies and allow the definite evaluation of intracranial arteries in most patients. TCCS is also useful for diagnosis and monitoring of vasospasm and detection of supratentorial hematomas (sensitivity 94%, specificity 95%) and aneurysms (sensitivity per patient 40–78%, specificity 90–91%), and may identify arteriovenous malformations. New developments are (1) UCAs that may increase the number of conclusive TCCS studies, (2) cerebral perfusion assessment, (3) measurement of arteriovenous cerebral transit time, which might enable the detection of small-vessel disease, and (4) site-targeted UCAs that may improve diagnosis and local drug delivery.

show abstract

“…Intravenous infusion of contrast generally provides a longer duration of enhancement than does a bolus injection. 1,12 In the future, the infusion of contrast may be the preferred method of delivery for many radiological US applications, including hepatic scanning. …”

Section: Vascular Agentsmentioning

confidence: 99%

“…A number of clinical studies using Levovist for contrastenhanced hepatic sonography have been reported. [1][2][3][12][13][14][15]22 Many reports have described the use of various blood pool agents and their ability to enhance the detection or conspicuity of hepatic lesions and to rule out the presence of tumors (Fig. 5).…”

Section: Tissue-specific Agentsmentioning

confidence: 99%

Contrast-Enhanced Hepatic Sonography

Merton

2002

Journal of Diagnostic Medical Sonography

View full text Add to dashboard Cite

Hepatic applications of sonography include evaluation of the gallbladder and bile ducts, assessment of patients with suspected portal hypertension, and evaluation of focal and diffuse parenchymal liver disease. Ultrasound imaging (US) is generally a reliable and accurate method to diagnose a variety of hepatic abnormalities; however, in some cases there is a need to improve sonography's sensitivity and specificity, particularly for the detection and characterization of hepatic masses. Recent clinical experience has shown that the addition of a US contrast agent can enhance sonography's diagnostic capabilities including improving assessments of hepatic blood flow and the detection and characterization of hepatic neoplasms. One intravenously administered US contrast agent is now available in the United States, but its approved indication is limited to echocardiographic applications. Additional agents that have more diagnostic applications are likely to become available. Contrast-enhanced sonography may play a significant role in the diagnosis and management of patients with suspected hepatic abnormalities. This article describes two generic types of US contrast agents—vascular agents and tissue-specific agents—and includes a review of recent published reports on clinical applications of contrast-enhanced hepatic sonography.

show abstract

Prolongation and optimization of Doppler enhancement with a microbubble US contrast agent by using continuous infusion: preliminary experience.

Cited by 136 publications

References 0 publications

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO ₂ Test Using an Ultrasound Contrast Agent (Levovist)

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO ₂ Test Using an Ultrasound Contrast Agent (Levovist)

Transcranial Color Duplex Sonography in Cerebrovascular Disease: A Systematic Review

Contrast-Enhanced Hepatic Sonography

Contact Info

Product

Resources

About

Prolongation and optimization of Doppler enhancement with a microbubble US contrast agent by using continuous infusion: preliminary experience.

Cited by 136 publications

References 0 publications

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO 2 Test Using an Ultrasound Contrast Agent (Levovist)

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO 2 Test Using an Ultrasound Contrast Agent (Levovist)

Transcranial Color Duplex Sonography in Cerebrovascular Disease: A Systematic Review

Contrast-Enhanced Hepatic Sonography

Contact Info

Product

Resources

About

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO ₂ Test Using an Ultrasound Contrast Agent (Levovist)

Measurement of Vasomotor Reserve in the Transcranial Doppler-CO ₂ Test Using an Ultrasound Contrast Agent (Levovist)