Prolongation of antipyrine half‐life after correction of severe anaemia due to hookworm infestation [letter]

Desai, Nayan; Karbhari, K; Paul, Thomas; Na, Kshirsagar; Sheth, U K

doi:10.1111/j.1365-2125.1982.tb01451.x

Cited by 8 publications

(1 citation statement)

References 5 publications

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“…In males, the antipyrine disposition test was carried out thrice with a gap of 10 days in between. Antipyrine was measured in saliva by the spectrophotometric method of Desai et al (1982) modified from Brodie et al (1949). Half-life (t./,), apparent volume of distribution (V), clearance (CL) and the area under the drug concentration-time curve (AUC) were calculated using standard equations (Shargel & Yu, 1980).…”

Section: Introduction Methodsmentioning

confidence: 99%

Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.

Desai

et al. 1988

Brit J Clinical Pharma

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The effect of the menstrual cycle on antipyrine pharmacokinetics was studied in 11 normal, healthy Indian female volunteers. Antipyrine half‐ life, apparent volume of distribution, clearance and AUC were calculated by standard methods. Results indicated that in females, antipyrine half‐life was significantly longer on day 5 as compared with that on days 15 and 21 of the menstrual cycle. It appears that hormonal changes during the menstrual cycle affect the pharmacokinetics of drugs in normal healthy females.

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Section: Introduction Methodsmentioning

confidence: 99%

Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.

Desai

et al. 1988

Brit J Clinical Pharma

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Influence of Disease on Drug Toxicity

Turner

1984

Archives of Toxicology

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Effect of iron deficiency anaemia and its treatment on single dose phenytoin bioavailability

Joshi¹,

Pohujani

Mehta³

et al. 1993

Eur J Clin Pharmacol

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Iron deficiency is a common nutritional deficiency, which leads to structural functional and enzymatic changes in the body that may affect the pharmacokinetics of drugs. The present study in 7 normal volunteers and 8 adult male patients with iron deficiency anaemia (IDA) was done to investigate the effect of iron deficiency and its treatment with total dose iron (TDI) on the bioavailability of a single dose of phenytoin. Phenytoin bioavailability was investigated before and 3 and 28 days after TDI. The bioavailability parameters Cmax, tmax, AUC and 2 h phenytoin concentrations were not significantly different in anaemic patients as compared to normal volunteers before or after treatment, except for an increase in tmax 28 days after TDI treatment.

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Prolongation of antipyrine half‐life after correction of severe anaemia due to hookworm infestation [letter]

Cited by 8 publications

References 5 publications

Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.

Influence of menstrual cycle on antipyrine pharmacokinetics in healthy Indian female volunteers.

Influence of Disease on Drug Toxicity

Effect of iron deficiency anaemia and its treatment on single dose phenytoin bioavailability

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