Prolonged Allograft Survival Following Spontaneous Recovery From Early Rejection

Dunn, D. C.; Randall, Gail

doi:10.1097/00007890-197403000-00011

Cited by 7 publications

(3 citation statements)

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“…Similarly those cadaver kidneys maintained for long periods by hypothermic perfusion preservation provide additional sources of study of cellular injury. 1 component of the transplant rejection process is ischaemia of the graft and obliterative lesions occur in the cortical vessels (Porter, Calne and Zukoski, 1964;Dunn and Randall, 1974). It is the ischaemia caused to the tubular cells which forms the basis for y-GT release studies in the urine of patients experiencing renal transplant rejection episodes.…”

Section: Human Renal Transplant Studiesmentioning

confidence: 99%

Urinary Gamma‐glutamyl Transpeptidase, an Indicator of Renal Ischaemic Injury and Homograft Rejection

Ward¹

1975

British Journal of Urology

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Gammaglutamyl transpeptidase is an enzyme primarily located in the brush border of the proximal convoluted tubules of the kidney. Its unique localisation in the renal cells most easily damaged by ischaemia and its ease of assay provides the rationale for its use in the measurement of renal ischaemic injury. Using a standard experimental animal model, canine urinary gamma-GT activity was shown to be increased up to 70-fold following 90 min of unilateral renal ischaemia and was significantly raised following only 5 min ischaemia. The urinary gamma-GT was used as a measure of ischaemic injury associated with renal transplantation in man and 20 consecutive patients undergoing kidney transplant were studied by daily 24-hour urinary gamma-GT estimations and excellent correlation was obtained between raised enzyme activity and the clinical diagnosis of transplant rejection.

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Section: Human Renal Transplant Studiesmentioning

confidence: 99%

Urinary Gamma‐glutamyl Transpeptidase, an Indicator of Renal Ischaemic Injury and Homograft Rejection

Ward¹

1975

British Journal of Urology

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“…Long-term survival of heart allografts in mice has been observed in strains which differ serologically only at H-2D or the so-called 'weak' end of the H-2 complex (Corry et al 1973). In addition, prolonged survival of rat renal allografts in certain Ag-B disparate combinations does occur (Salaman 1971, Ippolitto et al 1972, Dunn and Randall 1974, Pettirossi et al 1976. However, for most species, including rats, extended survival of heart allografts across an MHC barrier in an untreated host has not been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Strong and weak immune responses across the same major histocompatibility barrier in rats

1978

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Inbred rat strains, Fischer 344 (F-344) and Lewis (LEW), share the serologicalAg-Bl allele and react very weakly in mixed lymphocyte culture (MLC). Despite this apparent identity atAg-B, these strains differ markedly in their immune responses to anAg-B disparate third strain Marshall 520 (M-520) (Ag-B6). F-344 recipients allowed M-520 heart grafts an extended survival, whereas LEW recipients rejected them rapidly. F-344 and M-520 showed a weak response in MLC in contrast to a strong response for LEW and M-520. F-344 produced antisera in response to injection of M-520 cells that had a relatively high antibody titer but low cytotoxic activity. F-344 responded to another strain, Buffalo (BUF) (alsoAg-B6), in a similar fashion. F-344 apparently can produce a strong allogeneic response, as it was able to rapidly reject heart grafts from (LEW x Brown-Norway) F(1) donors (LBN) (Ag-B 1/3). The low response of F-344 to M-520 probably was not due to shared antigens between the two strains because M-520 heart grafts underwent rapid rejection in LEW hosts highly tolerant to F-344. To explain the contrasting response of F-344 and LEW to theAg-B6 disparity, we propose that it is controlled by an immune-response gene(s); that F-344 has a low-responding allele and LEW has a high-responding allele. The data do not reveal a location for this proposed gene. The high-responding allele appears to be dominant, as M-520 hearts were rejected rapidly by (F-344 x LEW) F(1) recipients.

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“…Few authors have reported observations on rejection processes in renal allografts in this species (Heron, 1971;Hobbs & Cliff, 1973), and there is even less information on attempts to modify rejection (Dunn & Randall, 1974).…”

mentioning

confidence: 99%

Immunosuppression in rabbits: skin and kidney allografts

Green¹

1975

Lab Anim

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Prolonged Allograft Survival Following Spontaneous Recovery From Early Rejection

Cited by 7 publications

References 0 publications

Urinary Gamma‐glutamyl Transpeptidase, an Indicator of Renal Ischaemic Injury and Homograft Rejection

Urinary Gamma‐glutamyl Transpeptidase, an Indicator of Renal Ischaemic Injury and Homograft Rejection

Strong and weak immune responses across the same major histocompatibility barrier in rats

Immunosuppression in rabbits: skin and kidney allografts

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