Prolonged breastfeeding reduces risk of breast cancer in Sri Lankan women: A case–control study

Silva, Malintha De; Senarath, Upul; Gunatilake, Mangala; Lokuhetty, Dilani

doi:10.1016/j.canep.2010.02.012

Cited by 43 publications

(32 citation statements)

References 41 publications

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“…Além disso, cabe aos profissionais de saúde encorajá-las permanentemente a amamentar seus filhos por períodos prolongados. 20,21 As mulheres nulíparas por sua vez, não se beneficiam do efeito protetor da amamentação, e assim, estas devem ser estimuladas à adoção de hábitos saudáveis que minimizem os outros fatores de risco passíveis de modificação.…”

Section: Discussionunclassified

Conhecimento e prática sobre os fatores de risco para o câncer de mama entre mulheres de 40 a 69 anos

Batiston

Tamaki

Bonilha

et al. 2011

Rev. Bras. Saude Mater. Infant.

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Section: Discussionunclassified

Conhecimento e prática sobre os fatores de risco para o câncer de mama entre mulheres de 40 a 69 anos

Batiston

Tamaki

Bonilha

et al. 2011

Rev. Bras. Saude Mater. Infant.

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“…Compared with women who breastfed a total of 0-11 months over their lifetimes, there was a 66.3% reduction in breast cancer risk in women who breastfed for 12-23 months, an 87.4% reduction in women who breastfed 24-35 months and a 94% reduction in women who breastfed 36-47 months. The mean duration of breastfeeding per child for at least 12 months was also associated with reduced risk of breast cancer (Silva et al, 2010).…”

Section: Breastfeeding: Benefits For Women and The Relationship With mentioning

confidence: 96%

Breastfeeding and its Relationship with Reduction of Breast Cancer: A Review

França-Botelho¹,

Ferreira²,

França³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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In this review, we describe the patterns of known immunological components in breast milk and examine the relationship between breastfeeding and reduced risk of breast cancer. The top risk factors for breast cancer are a woman's age and family history, specifically having a first-degree relative with breast cancer. Women that have a history of breastfeeding have been shown to have reduced rates of breast cancer. Although the specific cause has not been elucidated, previous studies have suggested that breastfeeding reduces the risk of breast cancer primarily through two mechanisms: the differentiation of breast tissue and reduction in the lifetime number of ovulatory cycles. In this context, one of the primary components of human milk that is postulated to affect cancer risk is alpha-lactalbumin. Tumour cell death can be induced by HAMLET (a human milk complex of alpha-lactalbumin and oleic acid). HAMLET induces apoptosis only in tumour cells, while normal differentiated cells are resistant to its effects. Therefore, HAMLET may provide safe and effective protection against the development of breast cancer. Mothers should be encouraged to breastfeed their babies because the complex components of human milk secretion make it an ideal food source for babies and clinical evidence has shown that there is a lower risk of breast cancer in women who breastfed their babies.

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“…Egger`s regression asymmetry test is used for publication bias [13]. To study the effect of a single study on meta-analysis we use the method in [14][15][16][17][18][19][20]. All the statistical analysis were performed with SPSS software on a machine with 4GB of RAM.…”

Section: Discussionmentioning

confidence: 99%

“…Eight studies [4,[15][16][17][18][19][20][21] comprising 12,041 breast cancer cases investigated the association between ever-breastfeeding and breast cancer risk. The obtained results from the researches do not lead us to a unique fact.…”

Section: Parity Breastfeeding and Breast Cancermentioning

confidence: 99%