Prolonged Duration of Breastfeeding Does Not Affect Lipid Profile in Adulthood

Hayosh, Ofri; Mandel, Dror; Mimouni, Francis; Lahat, Sharon; Marom, Ronella; Lubetzky, Ronit

doi:10.1089/bfm.2014.0158

Cited by 4 publications

(5 citation statements)

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“…Also, the duration of breastfeeding does not affect lipid profiles in young adults as has been shown by Hayosh et al, 2015. These results undermine the Hertfordshire study which suggested that the age of weaning and methods of infant feeding may influence adult serum low-density lipoprotein cholesterol (LDL-C) and mortality from ischemic heart disease in men [38]. The altered composition of breast milk, and the downstream effects this may have on subsequent adult health, are of great interest in regard to the metabolic programming during this early period.…”

Section: Discussionmentioning

confidence: 99%

Breast Milk Macronutrient Components in Prolonged Lactation

2018

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Human milk (HM) is the first dietary exposure in infancy and the best nutritional option for growth and healthy development of the newborn and infant. The concentrations of macronutrients, namely proteins, carbohydrates and lipids, change during lactation stages. HM has been studied extensively in the first 6 months of lactation, but there are limited data regarding milk composition beyond 1 or 2 years postpartum. The aim of our study was to describe longitudinal changes in HM macronutrient concentrations during the prolonged lactation of healthy mothers from the 1st to the 48th month. For the macronutrient content of milk of mothers breastfeeding for longer than 18 months, fat and protein increased and carbohydrates decreased significantly, compared with milk expressed by women breastfeeding up to 12 months. Moreover, the concentration of fat, protein and carbohydrates in HM over 2 years of lactation from the 24th to the 48th month remained at a stable level. However, analyzed macronutrients were positively (carbohydrate, r = 0.51) or negatively (fat, r = −0.36 and protein, r = −0.58) correlated with the amount of feeding. Our results create a greater potential for understanding the nutritional contribution of HM over 2 years of lactation and showed that the source of calories in breast milk for older children is mainly fat, while carbohydrates play a greater role in infant nutrition in the early stage. The observed changes of macronutrient concentrations from the 1st to the 48th month of lactation are probably related to the adaptation of milk composition to the increased energy demand of the intensively growing child.

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Section: Discussionmentioning

confidence: 99%

Breast Milk Macronutrient Components in Prolonged Lactation

2018

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“…The lack of association between breastfeeding and lipid biomarkers in our study agrees with previous studies (82,227,228), but differs from others (39,226). Another possible link between breastfeeding and metabolic disturbances in adulthood could be dietary habits (43,180), which in turn were associated with glucose and lipid biomarkers (119,122,(219)(220)(221).…”

Section: Discussionsupporting

confidence: 86%

“…Em adultos da terceira geração da coorte de Framingham não foi observada associação entre amamentação e as concentrações de colesterol total (CT) e triglicerídeos (TG), mas os indivíduos amamentados apresentaram maiores valores de HDL-c comparados aos que não receberam leite materno (79). Apesar destas evidências, estudos recentemente publicados não indicaram associação entre o aleitamento materno e o perfil lipídico na vida adulta (74,82). A literatura já sugeriu efeito protetor do aleitamento materno também sobre o DM mas de forma inconsistente e por mecanismos desconhecidos.…”

Section: Nascimento E O Aleitamento Materno: Recomendações Frequência E Associação Com Desfechos Tardiosunclassified

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Eventos precoces da vida, padrões alimentares e sua relação com o perfil cardiometabólico de jovens

Oliveira¹

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Agradeço à D'us pela oportunidade de concluir esta etapa de minha vida.À minha orientadora, Sandra Vivolo, agradeço imensamente por todo aprendizado, amizade, carinho e suporte desde a minha chegada em São Paulo. Obrigada representar um exemplo de pessoa e profissional que me inspira a ser um pedacinho do que você é! À minha mãe, Mônica Eshriqui, pelo amor incondicional, suporte emocional e confiança. Em especial, agradeço pelas ótimas lembranças na fase inicial do período sanduíche na Finlândia! Ao meu pai, Luiz Américo Leal de Oliveira, por inspirar força e coragem e pelo carinho, confiança e apoio de sempre! À minha avó, Regina Richter, por sempre acreditar e torcer por mim. Obrigada por me inspirar a ir longe! Ao meu amor e parceiro de vida, Rafael Diniz, por sempre estimular e apoiar meu crescimento profissional e pessoal. Muito obrigada pelo suporte diário! Ao meu irmão, Iago Eshriqui Oliveira, pela amizade e por provocar importantes reflexões.Aos meus tios e primas da família Eshriqui, José, Adriana, Daniela e Juliana e ao Itálico Bombonato, por todo carinho e incentivo. À Bianca, Luciana e Angélica, companheiras de NutriHs; e à Julia e Marilia, por me acolherem no grupo de pesquisa, pelo carinho e pelas trocas que possibilitaram rico aprendizado.Aos pesquisadores do FinHIT, obrigada por me receberem tão bem, pelos aprendizados e parceria de iniciada durante o estágio de pesquisa na Finlândia! Aos professores da Faculdade de Saúde Pública pelos ensinamentos de excelente qualidade.Aos funcionários e companheiros do Programa de pós Graduação em Nutrição em Saúde Pública pelo suporte ao longo desta trajetória. À Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) pelo apoio financeiro (processo nº 2017/13087-8) para o desenvolvimento desta tese de doutorado.Ao meu avô Samuel Eshriqui, que me ilumina e está sempre comigo.

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“…Randomized controlled studies also revealed that participants who had been randomized to a banked breastmilk group had lower levels of LDL/HDL ratio, TC, and LDL-C compared with those who received preterm formula at 13–16 years, although these differences were marginally significant [ 12 ]. Similarly, there also has been evidence to show that the effect of breastfeeding could not affect the lipid profile in late adolescents and adults [ 11 , 34 ]. However, some studies have reported the protective effect of breastfeeding on older people [ 13 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Association between Breastfeeding Duration and Lipid Profile among Children and Adolescents

Gao

Chen

et al. 2021

Nutrients

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To investigate the relationship between breastfeeding duration and lipid profile among children and adolescents, a cross-sectional survey using random cluster sampling was performed, and a national sample of 12,110 Chinese children and adolescents aged 5–19 years were collected. Breastfeeding duration and sociodemographic factors were collected by questionnaires. Fasting blood samples were obtained to test the lipid profile. Linear regression and logistic regression models were employed to evaluate the association between breastfeeding duration and lipid profile. We found that prolonged breastfeeding was related with a low level of total cholesterol (TC), LDL-C, HDL-C, and TC/HDL-C in children and adolescents. With an increased duration of breastfeeding, the magnitude of the association between breastfeeding and lipid profile enlarged. The levels of TC, LDL-C, HDL-C, and TC/HDL-C in participants who were breastfed for more than 12 months decreased by 6.225 (95% CI: −8.390, −4.059), 1.956 (95% CI: −3.709, −0.204), 1.273 (95% CI: −2.106, −0.440) mg/dL, and 0.072 (95%CI: −0.129, −0.015), respectively, compared with those who were not breastfed. The corresponding risk of high TC declined by 43% (aOR: 0.570, 95% CI: 0.403, 0.808). The association was similar in both boys and girls, but only statistically significant in children and young adolescents aged 5–14 years. This suggested that prolonged breastfeeding duration was related with low lipid levels and decreased abnormal lipid risk, especially in children and young adolescents. These findings support the intervention of prompting a prolonged duration of breastfeeding to improve the childhood lipid profile.

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Prolonged Duration of Breastfeeding Does Not Affect Lipid Profile in Adulthood

Abstract: Duration of breastfeeding does not affect lipid profiles in young adults. These findings do not support negative messages on the long-term effect of prolonged lactation generated by the Hertfordshire study.

Cited by 4 publications

References 9 publications

Breast Milk Macronutrient Components in Prolonged Lactation

Breast Milk Macronutrient Components in Prolonged Lactation

Eventos precoces da vida, padrões alimentares e sua relação com o perfil cardiometabólico de jovens

The Association between Breastfeeding Duration and Lipid Profile among Children and Adolescents

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