2015
DOI: 10.1002/mus.24355
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Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle

Abstract: Erythropoietin is unlikely to exert direct effects in human skeletal muscle due to a lack of Epo-R protein. Furthermore, prolonged ESA treatment does not seem to exert either direct or indirect effects on skeletal muscle gene expression.

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Cited by 9 publications
(14 citation statements)
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“…Furthermore, phosphorylation of ERK42/44, p38MAPK, and PPARγ in preadipocytes does not depend on Epo-R expression under normal culture conditions, but during adipocyte differentiation the expression of Epo-R increases in concomitance with increased phosphorylation of ERK42/44, p38MAPK, PPARγ, Akt, and STAT5 [2,19]. In our human study, we detected higher Epo-R mRNA levels in WAT than in bone marrow and than previously found in human skeletal muscle [13]. However, we were not able to measure any Epo-R Fig.…”
Section: Epo-r Mrna and Protein And Activation Of Signaling Pathways supporting
confidence: 54%
See 1 more Smart Citation
“…Furthermore, phosphorylation of ERK42/44, p38MAPK, and PPARγ in preadipocytes does not depend on Epo-R expression under normal culture conditions, but during adipocyte differentiation the expression of Epo-R increases in concomitance with increased phosphorylation of ERK42/44, p38MAPK, PPARγ, Akt, and STAT5 [2,19]. In our human study, we detected higher Epo-R mRNA levels in WAT than in bone marrow and than previously found in human skeletal muscle [13]. However, we were not able to measure any Epo-R Fig.…”
Section: Epo-r Mrna and Protein And Activation Of Signaling Pathways supporting
confidence: 54%
“…One explanation could be an increase in resting energy expenditure including fat oxidation [2], but only the former has been documented in healthy human subjects [6,7]. As regards direct peripheral actions of Epo, there is no evidence to support such effects in human skeletal muscle [12,13]. The effect of Epo treatment on WAT in humans has so far not been evaluated, but Epo-R protein and mRNA has been detected in WAT from mice in addition to a suppressive effect of Epo on fat accumulation and preadipocyte differentiation and expansion in vitro [2,14].…”
Section: Introductionmentioning
confidence: 99%
“…As no studies have been able to produce unambiguous evidence, the exact connection between Epo and the alleged oxidative adaptations still remains elusive. Moreover, a recently developed sensitive antibody indicates an absence of Epo-R protein expression in skeletal muscle (Christensen et al 2014). In line with this, a recent study concludes that even though they were able to detect Epo-R mRNA in human primary skeletal muscle cells, treatment with Epo did not influence myogenesis (Lamon et al 2014).…”
Section: Comparative Effects Of Epo and Training On Skeletal Muscle Tmentioning
confidence: 79%
“…Moreover, a recently developed sensitive antibody indicates an absence of Epo‐R protein expression in skeletal muscle (Christensen et al . ). In line with this, a recent study concludes that even though they were able to detect Epo‐R mRNA in human primary skeletal muscle cells, treatment with Epo did not influence myogenesis (Lamon et al .…”
Section: Discussionmentioning
confidence: 97%
“…The study was approved by the Local Ethical Committee of Central Denmark Region (M-20110035), and is registered at www.clinicaltrials.gov (NCT01320449). A detailed description of the study design and data regarding skeletal muscle and metabolic effects of ESA treatment and aerobic training has been published [6,7,16,23].…”
Section: Participantsmentioning
confidence: 99%