2024
DOI: 10.1002/2211-5463.13891
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Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance

Shehnaz Bano,
Shyam More,
Dattatray S. Mongad
et al.

Abstract: Glucose homeostasis is maintained by insulin. Insulin resistance is caused by multiple factors including hereditary factors and diet. The molecular mechanism underlying insulin resistance (IR) is not completely understood. Hyperinsulinemia often precedes insulin resistance and Type 2 diabetes. We had previously shown that prolonged exposure of insulin‐responsive cells to insulin in the absence of high levels of glucose led to insulin resistance. In the present study, we show that the underlying cause for the i… Show more

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