2004
DOI: 10.1158/0008-5472.can-03-2645
|View full text |Cite
|
Sign up to set email alerts
|

Prolonged Extracellular Signal-Regulated Kinase 1/2 Activation during Fibroblast Growth Factor 1- or Heregulin β1-Induced Antiestrogen-Resistant Growth of Breast Cancer Cells Is Resistant to Mitogen-Activated Protein/Extracellular Regulated Kinase Kinase Inhibitors

Abstract: Increased growth factor receptor signaling is implicated in antiestrogen-resistant breast tumors suggesting that abrogation of such signaling could restore or prolong sensitivity to antihormonal agents. Activation of the mitogen-activated protein/extracellular regulated kinase kinase (MEK)-extracellular regulated kinase (ERK)1/2 cascade is a common component of such pathways. We investigated the ability of the MEK activation inhibitor U0126 to block the increased growth of estrogen receptor-positive MCF-7 brea… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

5
31
0

Year Published

2007
2007
2020
2020

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 35 publications
(36 citation statements)
references
References 60 publications
5
31
0
Order By: Relevance
“…38 Due to these superior qualities, Fe-Au NRs also have the potential to replace SPIONs in targeted molecular imaging and/or hyperthermia, where high particle concentrations are needed. 38,39 Thus, this study confirms that the physical and chemical properties of the nanorods can be tuned to selectively bind to cells 25 expressing high level of receptors, and suggests that targeting metastasized cells in circulation for diagnostic applications could be highly selective.…”
Section: Discussionsupporting
confidence: 70%
See 4 more Smart Citations
“…38 Due to these superior qualities, Fe-Au NRs also have the potential to replace SPIONs in targeted molecular imaging and/or hyperthermia, where high particle concentrations are needed. 38,39 Thus, this study confirms that the physical and chemical properties of the nanorods can be tuned to selectively bind to cells 25 expressing high level of receptors, and suggests that targeting metastasized cells in circulation for diagnostic applications could be highly selective.…”
Section: Discussionsupporting
confidence: 70%
“…Sequential images in Figure 2B show how the scattered light intensity depends on the orientation of the rod where q is the angle between the polarization axis and the rod's longitudinal axis. The optical signature of the gold nanorod was characterized by the polarization dependent change in the scattering intensity of the two 25 bright stripes, which is a result of optical effects associated with the cylindrical geometry of the nanorod, the plasmonic modes excited on the Au section of the nanorod, the ultra-high collection angle of the 1.49 NA objective lens, and the illumination geometry. The dark stripe along the middle of the rod's longitudinal axis resulted from the shadow produced by the cylindrical rod when imaged in transmission direction.…”
Section: Optical and Magnetic Properties Of The Nanorodsmentioning
confidence: 99%
See 3 more Smart Citations