Prolonged immune checkpoint inhibitor response of a patient with a RET rearranged non-small cell lung cancer and high tumour mutational burden: case report and review of the literature

Dursun, Safiye; Theunissen, Tom E. J.; Li, Xiaofei; Speel, Ernst‐Jan M.; Hendriks, Lizza

doi:10.21037/pcm-2020-potb-03

Cited by 1 publication

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“…Data related to TMB among patients with RET fusion-positive NSCLC are limited. Among the available studies, most have reported a presence of low/intermediate TMB (often defined as either ≤5, <10 or <20 mutations per megabase) in majority of the included patients with RET fusion-positive NSCLC [19,22,33,[49][50][51][52]. Likewise, data related to the level of PD-L1 expression in this patient population are not consistent.…”

Section: Discussionmentioning

confidence: 85%

Efficacy of Immune Checkpoint Inhibitor Therapy in Patients With RET Fusion-Positive Non-Small-Cell Lung Cancer

et al. 2021

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Aim: To describe outcomes of patients with RET fusion-positive non-small-cell lung cancer (NSCLC) who received immune checkpoint inhibitor (ICI)-based treatments in the US. Patients & methods: Using de-identified Flatiron Health-Foundation Medicine NSCLC Clinico-Genomic and Guardant Health databases, treatment patterns and outcomes of 69 patients with advanced/metastatic RET fusion-positive NSCLC who received ICI-based treatment were described. Results: Median real-world progression-free survival and overall survival months were 4.2 (95% CI: 1.4–8.4) and 19.1 (6.9–not reached), respectively, among patients in Clinico-Genomic database (n = 17) receiving first-line ICI-based therapy. In the Guardant Health database, progression-free survival was unavailable, and the median overall survival was not reached (n = 29). Conclusion: Outcomes associated with ICI-based treatments in the first-line setting among patients with RET fusion-positive NSCLC are consistent with unselected populations reported in literature.

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