Prolonged Intake of Juice (Citrus Unshiu) Reinforced with .BETA.-Crypthoxanthin Has an Effect on Circulating Bone Biochemical Markers in Normal Individuals

Yamaguchi, Masayoshi; Igarashi, Aki; Uchiyama, Satoshi; Morita, Seiichi; Sugawara, Kuniaki; Sumida, Takashi

doi:10.1248/jhs.50.619

Cited by 35 publications

(31 citation statements)

References 22 publications

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“…These findings suggest that the intake of β-cryptoxanthin reinforced juice has a stimulatory effect on osteoblastic bone formation and inhibitory effect on osteoclastic bone resorption in normal individuals. 49) The serum β-cryptoxanthin concentration was significantly increased with the intake of regular juice for 56 days. 50) This increase was significantly enhanced after the intake of β-cryptoxanthinreinforced juice.…”

Section: Effects Of β-Cryptoxanthin In Healthy Individuals and Menopamentioning

confidence: 95%

“…[49][50][51] Effect on Healthy Individuals: Twenty-one volunteers (10 males and 11 females) were divided into two groups of ten volunteers (5 males and 5 females) and eleven volunteers (5 males and 6 females), and each group was given sequentially juice (192 ml) containing two different contents of β-cryptoxanthin once a day for 28 or 56 days as follows: either regular juice with naturally occurring 802 µg β-cryptoxanthin/100 ml or a reinforced juice containing 1500 µg β-cryptoxanthin/100 ml. 49) The intake of regular juice for 28 or 56 days in healthy subjects caused a significant increase in serum γ-carboxylated osteocalcin concentration, and the intake for 56 days produced a significant decrease in serum bone TRACP activity. Moreover, the intake of the β-cryptoxanthin reinforced juice for 28 or 56 days caused a significant increase in serum γ-carboxylated osteocalcin concentration and a corresponding decrease in serum bone TRACP activity and N-telopeptide of type I collagen.…”

Section: Effects Of β-Cryptoxanthin In Healthy Individuals and Menopamentioning

confidence: 99%

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.BETA.-Cryptoxanthin and Bone Metabolism: The Preventive Role in Osteoporosis

Yamaguchi

2008

JOURNAL OF HEALTH SCIENCE

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Bone loss with aging induces osteoporosis. The most dramatic expression of the disease is represented by fractures of the proximal femur. Pharmacologic and nutritional factors may play a role in the prevention of bone loss with aging. β-Cryptoxanthin, a kind of carotenoid, is abundant in Satsuma mandarin orange (Citrus unshiu MARC.). Amoung various carotenoids including β-cryptoxanthin, lutein, lycopene, β-carotene, astaxanthin, and rutin, β-cryptoxanthin has been found to have a unique anabolic effect on bone calcification in vitro. Hesperidin, which is contained in Satsuma mandarin orange, did not have an anabolic effect on bone calcification in vitro. β-Cryptoxanthin has stimulatory effects on osteoblastic bone formation and inhibitory effects on osteoclastic bone resorption in vitro, thereby increasing bone mass. β-Cryptoxanthin has an effect on the gene expression of various proteins which are related to osteoblastic bone formation and mineralization in vitro. β-Cryptoxanthin has inhibitory effects on enzyme activity which is related to osteoclastic bone resororption, and the carotenoid induces apoptosis of mature osteoclastic cells in vitro. Oral administration of β-cryptoxanthin has been shown to have the anabolic effects on bone components in young and aged rats, and the administration has the preventive effects on bone loss in streptozotocin-diabetic rats and ovariectomized rats in vivo. Moreover, the intake of β-cryptoxanthin-reinforced juice for longer periods has been shown to have both stimulatory effects on bone formation and inhibitory effects on bone resorption in healthy human or postmenopausal women in evaluating with serum biochemical markers of bone metabolism in vivo. Thus the intake of dietary β-cryptoxanthin may have a preventive effect on osteoporosis due to stimulating bone formation and due to inhibiting bone resorption. Moreover, epidemiological studies suggest the potential role of β-cryptoxanthin as a sustainable nutritional approach to improving bone health of human subjects. β-Cryptoxanthin is an important food factor in maintaining bone healthy and in preventing osteoporosis.

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Section: Effects Of β-Cryptoxanthin In Healthy Individuals and Menopamentioning

confidence: 95%

Section: Effects Of β-Cryptoxanthin In Healthy Individuals and Menopamentioning

confidence: 99%

.BETA.-Cryptoxanthin and Bone Metabolism: The Preventive Role in Osteoporosis

Yamaguchi

2008

JOURNAL OF HEALTH SCIENCE

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“…Moreover, it has been found that streptozotocin-induced bone loss in rats with a diabetic state is prevented by the oral administration of ß-cryptoxanthin in vivo (15). The prolonged intake of dietary ß-cryptoxanthin has been shown to have a stimulatory effect on bone formation and an inhibitory effect on bone resorption due to estimating serum biochemical markers of bone metabolism in normal individuals (16). ß-Cryptoxanthin may have a preventive effect on osteoporosis with increasing age.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Uchiyama

Yamaguchi²

2006

Int J Mol Med

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Abstract. The effect of ß-cryptoxanthin, a kind of carotenoid, on ovariectomy-induced bone loss was investigated. ß-Cryptoxanthin was isolated from Satsuma mandarin (Citrus unshu. MARC). ß-cryptoxanthin (5 or 10 μg/100 g body weight) was orally administered once daily for 3 months to ovariectomized (OVX) rats. OVX induced a significant increase in body weight and a significant decrease in serum calcium and inorganic phosphorus concentrations as compared with those of shamoperated (control) rats. These alterations induced by OVX were significantly prevented by the administration of ß-cryptoxanthin (5 or 10 μg/100 g). The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX induced a significant decrease in mineral content and mineral density in the femoral-diaphyseal and -metaphyseal tissues and polar strength strain index in the metaphyseal tissues. These decreases were significantly prevented by the administration of ß-cryptoxanthin (5 or 10 μg/100 g). Moreover, OVX induced a significant decrease in calcium content and alkaline phosphatase activity in the femoraldiaphyseal and -metaphyseal tissues and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were significantly prevented by the administration of ß-cryptoxanthin (5 or 10 μg/100 g). This study demonstrates that ß-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo.

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“…[20][21][22][23][24][25][26][27][28][29][30] Whether the supplemental intake of MK-4 (vitamin K 2 ) as nutrient has anabolic effects on bone components has not been fully determined, although MK-4 is used as therapeutic tool for osteoporosis treatment in the clinical setting. Cal K 2 was developed as a new MK-4 supplement containing calcium.…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Cal K2 Containing Menaquinone-4 (Vitamin K2) Enhances Serum r-Carboxylated Osteocalcin and Biochemical Components in the Femoral Tissues of Rats

Uchiyama

Kimura

Masuda

et al. 2006

JOURNAL OF HEALTH SCIENCE

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The effects of menaquinone-4 (MK-4; vitamin K 2 ) supplemented egg shell calcium (Cal K 2 ) on bone components in the femoral-diaphyseal (cortical bone) and -metaphyseal (trabecular bone) tissues of rats was investigated. Cal K 2 contained calcium carbonate (Ca 100 mg/g) and MK-4 (593 µ µ µ µ µg/g). Rats were orally administered a solution of Cal K 2 (10, 25, or 50 mg/ml/100 g body weight) or placebo (without MK-4, 50 mg/ml/100 g body weight) once daily for 7 days. The serum r-carboxylated osteocalcin concentration, which is produced in osteoblastic cells, was significantly increased after the administration of Cal K 2 (50 mg/100 g body weight) as compared with that in the control group or placebocontrol group without MK-4. Calcium content and alkaline phosphatase activity in the femoral-diaphyseal tissues were significantly increased after Cal K 2 (25 or 50 mg/100 g) as compared with that in the placebocontrol group. Femoral-metaphyseal calcium content was significantly increased after the administration of Cal K 2 (25 or 50 mg/100 g) as compared with that in the control group. DNA content in the femoral-diaphyseal and -metaphyseal tissues was significantly increased after the administration of Cal K 2 (50 mg/100 g) as compared with that in the control or placebocontrolled group. This study demonstrates that the oral administration of Cal K 2 containing MK-4 has anabolic effects on bone components in rats. Supplemental Cal K 2 may have a role in the prevention of bone loss with aging.

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Prolonged Intake of Juice (Citrus Unshiu) Reinforced with .BETA.-Crypthoxanthin Has an Effect on Circulating Bone Biochemical Markers in Normal Individuals

Cited by 35 publications

References 22 publications

.BETA.-Cryptoxanthin and Bone Metabolism: The Preventive Role in Osteoporosis

.BETA.-Cryptoxanthin and Bone Metabolism: The Preventive Role in Osteoporosis

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Oral Administration of Cal K2 Containing Menaquinone-4 (Vitamin K2) Enhances Serum r-Carboxylated Osteocalcin and Biochemical Components in the Femoral Tissues of Rats

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