Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: Neuromodulation by neuropeptide Y?

Potter, Erica K.

doi:10.1016/s0304-3940(85)80065-3

Cited by 183 publications

(92 citation statements)

References 6 publications

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“…(There are no effects of exogenous galanin on cardiac vagal action in the dog; Moriarty et al 1992). This is in keeping with the hypothesis that the factor responsible for the effect seen following sympathetic stimulation in dogs is not galanin (Moriarty et al 1992), but is probably neuropeptide Y (Potter, 1985).…”

Section: Discussionsupporting

confidence: 75%

Galanin antagonist effects on cardiac vagal inhibitory actions of sympathetic stimulation in anaesthetized cats and dogs.

Ulman

Moriarty

Potter

et al. 1993

The Journal of Physiology

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SUMMARY1. Galantide, a putative galanin antagonist composed of twenty amino acids, caused a significant reduction in the vagal attenuating action of galanin injection (20 ,ug/kg; 6-2 nmol/kg) in anaesthetized cats at both ten times (137 ,ug/kg; 62 nmol/kg) and twenty-five times (343 ,ug/kg: 156 nmol/kg) the molar dose of galanin. Galantide did not block the depressor action of galanin in these animals.2. Galantide, at both doses, also significantly reduced the vagal attenuating action of a 5 min period of cardiac sympathetic stimulation at 16 Hz in anaesthetized cats.3. In anaesthetized dogs, galantide, at the same dose used in cats (137 ,ug/kg; 62 nmol/kg) had no significant effect on the vagal attenuation evoked by cardiac sympathetic stimulation or injection of neuropeptide Y (35 jg/kg; 8-2 nmol/kg).4. This study therefore demonstrates antagonist properties of galantide on the vagal inhibitory action of galanin. It supports the hypothesis that the vagal inhibitory factor released by cardiac sympathetic nerve stimulation in the cat, but not the dog, is galanin, although it does not exclude the possibility of other factors playing a more minor role. Because galantide was not shown to block the depressor action of galanin, this study also suggests that there may be more than one galanin receptor subtype.

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Section: Discussionsupporting

confidence: 75%

Galanin antagonist effects on cardiac vagal inhibitory actions of sympathetic stimulation in anaesthetized cats and dogs.

Ulman

Moriarty

Potter

et al. 1993

The Journal of Physiology

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“…In that context, it is unlikely that the use of beta-blockers has influenced only the results obtained with the HRV. There is consistent evidence that beta-blockers increase CVM through both a direct effect on the central nervous system 3 and a peripheral effect, due to a reduction in heart rate, which increases the probability that acetylcholine acts on the slow diastolic depolarization of sinoatrial node cells 4 , and due to a reduction in the pre-synaptic inhibition of the release of acetylcholine mediated by sympathetic activity 5 .…”

Section: Santos Et Al Comparison Of Vagal Assessment Methodsmentioning

confidence: 98%

“…Thus, would avoiding betablockers not provide more accurate results? C) time domain variables tend to be more precise in long-lasting registries 5 . D) Of the variables selected to measure "vagal action", would SDNN (standard deviation of normal RR intervals) not be better for studying the sympathetic nervous system?…”

mentioning

confidence: 99%

Comparação entre métodos de avaliação da modulação vagal autonômica

Santos¹,

Sousa²

2012

Arq. Bras. Cardiol.

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“…Recent work by Potter (1984Potter ( , 1985. confirmed by Warner & Levy (1989), has established that short periods (1-2 min) of stimulation of the cardiac sympathetic nerves to the heart in anaesthetized dogs result in a prolonged inhibit,ion of the ability of the vagus nerves to slow the heart.…”

Section: Introductionmentioning

confidence: 92%

“…Thus. Potter (1985) proposed that the prolonged vagal inhibition following stimulation of cardiac sympathetic nerves, was due to release of NPY from these nerves.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of cardiac vagal action by galanin but not neuropeptide Y in the brush‐tailed possum Trichosurus vulpecula.

Courtice

Potter

McCloskey

1993

The Journal of Physiology

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SUMMARY1. Stimulation of the right cardiac sympathetic nerve for 2 min at 16 Hz in the presence of either ,3-or a-and /3-adrenoceptor blockade evoked attenuation of cardiac vagal action in eight possums: 31-3 + 103 % maximum inhibition of cardiac vagal action on prolonging pulse interval, with a time to half-recovery of 4-9 + 1-1 min.2. Intravenous injection of galanin (2-3 5 nmol kg-') evoked similar inhibition of cardiac vagal action: 41-3 + 41 % maximum inhibition of cardiac vagal action on pulse interval, with a time to half-recovery of 13-4+2-3 min.3.

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Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: Neuromodulation by neuropeptide Y?

Cited by 183 publications

References 6 publications

Galanin antagonist effects on cardiac vagal inhibitory actions of sympathetic stimulation in anaesthetized cats and dogs.

Galanin antagonist effects on cardiac vagal inhibitory actions of sympathetic stimulation in anaesthetized cats and dogs.

Comparação entre métodos de avaliação da modulação vagal autonômica

Inhibition of cardiac vagal action by galanin but not neuropeptide Y in the brush‐tailed possum Trichosurus vulpecula.

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