Prolonged occupational exposure leads to allergic airway sensitization and chronic airway and systemic inflammation in professional firefighters

Gianniou, Niki; Κatsaounou, Paraskevi; Dima, Efrossini; Giannakopoulou, Chariklia-Eleni; Kardara, Matina; Saltagianni, Vassiliki; Trigidou, Rodoula; Kokkini, Aggeliki; Bakakos, Petros; Markozannes, Evangelos; Litsiou, Eleni; Tsakatikas, Alexandros; Papadopoulos, Christos; Roussos, Charis; Koulouris, Nikolaos; Rovina, Nikoletta

doi:10.1016/j.rmed.2016.07.006

Cited by 33 publications

(37 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Allergic airway sensitivity has been associated with inhalational exposure to combustion products, and occupational exposures have been associated with eosinophil production . A recent study among professional firefighters who had chronic and prolonged exposure to smoke and numerous ultrafine particulates reported statistically significantly higher percentage of eosinophils on induced sputum and bronchoalveolar lavage fluid testing compared with healthy subjects or firefighter trainees, and demonstrated a significant correlation between the percentage of sputum eosinophils and years of service . Identification of eosinophilic asthma versus non‐eosinophilic asthma has important implications for identification of potential causes and for selecting appropriate treatments .…”

Section: Discussionmentioning

confidence: 99%

Non‐malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta‐analysis

Thapa

Tomasi

Cox‐Ganser

et al. 2019

American J Industrial Med

View full text Add to dashboard Cite

Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Results:We analyzed 62 articles. We identified 11 cases of NMRD. Nine (30%) of 30 cross-sectional studies and one (4%) of 26 mortality studies had strong evidence. The summary odds ratio and SMR for the cross-sectional and mortality meta-analyses were 3.83 (95% confidence interval [CI], 2.28-6.51) and 0.90 (95%CI, 0.82-0.99), respectively. Conclusion:Available evidence supports rubber manufacturing emissions as a potential risk factor for NMRD-related morbidity. Further investigations with longer follow-up periods and inclusion of short-tenured workers could further define risks for NMRD and identify prevention strategies. K E Y W O R D Schronic bronchitis, chronic obstructive pulmonary diseases, emphysema, eosinophilia, nonmalignant respiratory disease, occupational asthma, occupational lung disease, rubber

show abstract

Section: Discussionmentioning

confidence: 99%

Non‐malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta‐analysis

Thapa

Tomasi

Cox‐Ganser

et al. 2019

American J Industrial Med

View full text Add to dashboard Cite

show abstract

“…It is conceivable that the high prevalence of OSA risk in the subjects of this study may be linked to potential pulmonary function problems in firefighters. 30 Excessive daytime sleepiness may be presented as a form of hypersomnolence which in turn, is one of the cardinal symptoms in depressive disorders. 31 Depression among firefighters is strongly associated with difficulties in emotion regulation that are commonly encountered in post-traumatic stress disorder.…”

Section: Discussionmentioning

confidence: 99%

Sleep Patterns of Firefighters with Shift Working Schedules in Seoul Metropolitan Area

Kim¹,

Jung²,

Choi³

et al. 2017

Sleep Med Res

View full text Add to dashboard Cite

Background and ObjectiveaaFirefighters suffer from irregular and inadequate sleep, often due to their shift work schedule. The purpose of this study was to investigate the shift work schedules and their effects on the quality of sleep in Korean firefighters. MethodsaaThis study included firefighters in the Seoul Metropolitan area, who participated in the "Firefighters' Healing Camp" and answered questionnaires for their shift work schedules and sleeprelated symptoms. Among 180 participating firefighters, 110 subjects completed detailed sleep questionnaires, which included the Pittsburgh Sleep Quality Index, the Insomnia Severity Index, the Epworth Sleepiness Score, the Stanford Sleepiness Score, the Fatigue Severity Scale, and the Berlin Questionnaire, and provided details of their shift work schedule and duration for the last 3 weeks. resultsaaAmong 110 respondents, 78.2% self-reported sleep disturbance and approximately 60% of the participating firefighters had a certain degree of insomnia. Furthermore, more than 50% of the firefighters complained of excessive daytime sleepiness, with 31.8% having a risk of obstructive sleep apnea (OSA). The firefighters in the frequent night-shift (NS) working pattern (5 or more days for 3 weeks), showed significantly higher Pittsburg Sleep Quality Index global score than those in the infrequent (less than 5 days) NS group (8.8 ± 3.6 vs. 6.7 ± 2.7, p = 0.014). However, the frequent NS working pattern was not associated with excessive daytime sleepiness or OSA risk. ConclusionsaaThe participating firefighters reported a high prevalence of various sleep problems. Frequent NS working may be responsible for poor sleep quality in firefighters. Sleep Med res 2017;8(2):68-75

show abstract

“…It has been reported that cardiovascular disease is the leading cause of excess morbidity and mortality in firefighters [9,42,43]. Some investigators have notice a higher incidence of respiratory and pulmonary symptoms as well as airways hyper-responsiveness and decay in lung function of firefighters during fire combat activities [9,81,82]. In addition, tobacco smoke is associated with the development of lung cancer among other types of cancers and diseases, namely leukemia and cancers of the urinary and aerodigestive tracts as well as of stomach, pancreas, liver, breast, prostate, and colorectal tissues [15].…”

Section: Cumulative Effects Of Tobacco Smoke and Fire Emissionsmentioning

confidence: 99%

Individual and cumulative impacts of fire emissions and tobacco consumption on wildland firefighters’ total exposure to polycyclic aromatic hydrocarbons

Oliveira

Slezáková

Magalhães

et al. 2017

Journal of Hazardous Materials

View full text Add to dashboard Cite

There is limited information about wildland firefighters' exposure to polycyclic aromatic hydrocarbons (PAHs), being scarce studies that included the impact of tobacco consumption. Thus, this work evaluated the individual and cumulative impacts of firefighting activities and smoking on wildland firefighters' total exposure to PAHs. Six urinary PAH metabolites (1-hydroxynaphthalene (1OHNaph), 1-hydroxyacenaphthene (1OHAce), 2-hydroxyfluorene (2OHFlu), 1-hydroxyphenanthrene (1OHPhen), 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene (3OHB[a]P)) were quantified by high-performance liquid chromatography with fluorescence detection. Firefighters from three fire stations were characterized and organized in three groups: non-smoking and non-exposed to fire emissions (NSNExp), smoking non-exposed (SNExp), and smoking exposed (SExp) individuals. 1OHNaph+1OHAce were the most predominant OH-PAHs (66-91% ∑OH-PAHs), followed by 2OHFlu (2.8-28%), 1OHPhen (1.3-7%), and 1OHPy (1.4-6%). 3OHB[a]P, the carcinogenicity PAH biomarker, was not detected. Regular consumption of tobacco increased 76-412% ∑OH-PAHs. Fire combat activities promoted significant increments of 158-551% ∑OH-PAHs. 2OHFlu was the most affected compound by firefighting activities (111-1068%), while 1OHNaph+1OHAce presented the more pronounced increments due to tobacco consumption (22-339%); 1OHPhen (76-176%) and 1OHPy (20-220%) were the least influenced ones. OH-PAH levels of SExp firefighters were significantly higher than in other groups, suggesting that these subjects may be more vulnerable to develop and/or aggravate diseases related with PAHs exposure.

show abstract

Prolonged occupational exposure leads to allergic airway sensitization and chronic airway and systemic inflammation in professional firefighters

Abstract: These results indicate a "dose-response" effect of chronic exposure to a polluted environment on bronchial and systemic inflammation in professional firefighters.

Cited by 33 publications

References 48 publications

Non‐malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta‐analysis

Non‐malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta‐analysis

Sleep Patterns of Firefighters with Shift Working Schedules in Seoul Metropolitan Area

Individual and cumulative impacts of fire emissions and tobacco consumption on wildland firefighters’ total exposure to polycyclic aromatic hydrocarbons

Contact Info

Product

Resources

About