Prolonged periods without food intake during pregnancy increase risk for elevated maternal corticotropin-releasing hormone concentrations

Herrmann, Tracy; Siega‐Riz, Anna Maria; Hobel, Calvin J.; Aurora, Chandra; Dunkel-Schetter, Christine

doi:10.1067/mob.2001.115863

Cited by 83 publications

(69 citation statements)

References 25 publications

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“…Maternal and not fetal cortisol levels were significantly increased by the fasting. Interestingly, our results at term concord with previous animal and human reports indicating that id pregnancy short term food deprivation induces rapid expression of corticotropin releasing hormone (CRH) in several brain regions, parallel increased plasma concentrations and risk of preterm birth, without any direct fetal effect [23]. Since no mother received an intravenous glucose load or labored, the results are a reflection of the short term starvation effect [24,25].…”

Section: Discussionsupporting

confidence: 70%

The Effect of Short Term Maternal Fasting on Fetal Biophysical and Neonatal Biochemical Profile - A Pilot Study and a Short Critical Review of the Literature

Grisaru‐Granovsky¹,

Hamudi²,

Samueloff³

et al. 2008

TOWHJ

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Abstract:Aim: To determine the net effect of strict maternal short term fasting on fetal biophysical parameters.Study Design: Prospective observational study among healthy women with a single term fetus, delivered by scheduled cesarean who had strict preoperative fast. Each subject serves as its own control. The Biophysical Profile Score was recorded. Statistics used paired t , non parametric Wilcoxon , McNemar tests (as appropriate) and correlations.Results: Twenty one women were recruited. We found no difference when the separate scoring entities were analyzed in the two maternal states. No correlation was found between maternal -fetal biochemical and hormonal status. All neonates were healthy.Conclusion: Short term fasting in healthy mothers is well tolerated by both the mother and the neonate. Standards need not to be adapted in the assessment of the low risk fetus and glucose containing drinks should not be offered in order to decrease the false positive rate of the biophysical profile.

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Section: Discussionsupporting

confidence: 70%

The Effect of Short Term Maternal Fasting on Fetal Biophysical and Neonatal Biochemical Profile - A Pilot Study and a Short Critical Review of the Literature

Grisaru‐Granovsky¹,

Hamudi²,

Samueloff³

et al. 2008

TOWHJ

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“…[1][2][3][4][5][6][7][8][9][10] Accelerated starvation is noticed in pregnant women compared with nonpregnant women after only 12 hours of fasting. 6 After a period of fasting for 13 hours or more, maternal corticotrophin-releasing hormone is elevated compared with those without food for periods less than 13 hours.…”

Section: Introductionmentioning

confidence: 99%

“…6 After a period of fasting for 13 hours or more, maternal corticotrophin-releasing hormone is elevated compared with those without food for periods less than 13 hours. 7 There are few studies to discuss Ramadan fasting and its effect on neonatal health. 10,11 Malhotra et al compared metabolic changes in 11 Ramadan-fasted and 11 overnight-fasted pregnant women and none of the Ramadan-fasted mothers had a completely normal set of biochemical values at the end of the fast day.…”

Section: Introductionmentioning

confidence: 99%

Maternal Ramadan Fasting and Neonatal Health

Kavehmanesh

Abolghasemi

2004

J Perinatol

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This retrospective cohort study sought to determine the effects of maternal Ramadan fasting during pregnancy on neonatal birth weight as an important aspect of fetal health. It was carried out among healthy women who were admitted for their neonate delivery at two medical centers in Tehran from January to September 2000. Neonates of 284 mothers with a history of Ramadan fasting during pregnancy were compared with neonates of 255 mothers who did not have a history of fasting during their pregnancies. On univariate analysis, neonatal birth weight of the fasted group was 100 g more than those of the nonfasted group (p ¼ 0.009). However, body mass index (BMI) of the fasted mothers was greater than that of the nonfasted mothers. When controlling for maternal BMI on neonatal birth weight, multiple linear regression models showed that neonates of fasted women were 71 g heavier than those of the nonfasted group, which was not statistically significant (p ¼ 0.1). We conclude that maternal fasting during Ramadan did not have a significant effect on the neonatal birth weight. Other health effects that we did not observe could have occurred.

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“…It is not surprising that cumulative impact of enduring stress, such as economic position and racism may condition or unmask neuroendocrine mechanisms 'priming' the likelihood of preterm delivery. Low family income has been associated with high maternal CRH (78). In addition, reported findings from the Black Women Health Study show an impact of individually directed racism on the risk of preterm delivery (79).…”

Section: Crh In the Female Reproductive Systemmentioning

confidence: 99%

Corticotropin releasing hormone and the immune/inflammatory response

Mastorakos¹,

Karoutsou²,

Mizamtsidi³

2006

eur j endocrinol

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Hypothalamic corticotropin-releasing hormone (CRH) acts as the major physiologic ACTH secretagog. Moreover, CRH is distributed in the brain and spinal cord, adrenal medulla, testes, ovaries, gastrointestinal tract, pancreas, myometrium, endometrium, placenta, and diverse inflammatory sites. Immunoreactive CRH has been found in the cytoplasm of immune accessory cells (macrophages, endothelial cells, and tissue fibroblasts), and in inflammatory sites of both acute and chronic inflammation (synovial lining cell layers and blood vessels from the joints of patients with rheumatoid arthritis and osteoarthritis). Additionally, the local presence of CRH in the uveitic eyes, cytoplasm of inflammatory cells (macrophages, lymphocytes, and polymorphonuclear cells) infiltrating the iris, ciliary body, vitreous, retina, and choroid appears to be of pivotal importance in the process of experimental autoimmune uveoretinitis. Traditionally, hypothalamic CRH has been considered to act indirectly in an anti-inflammatory fashion, since the end product of the hypothalamic-pituitaryadrenal axis is cortisol, a well-known anti-inflammatory compound. However, CRH produced at peripheral inflammatory sites has been shown to participate in an autocrine/paracrine stimulation of inflammation. Thus, CRH may have a peripheral, primarily activating role on the immune system. The mechanisms of the CRH-mediated component of the immune/inflammatory response are still unclear. CRH in inflammatory sites seems to be involved in the activation of the Fas/Fas ligand system. Furthermore, locally produced embryonic and endometrial CRH plays a role in both the aseptic inflammatory process of implantation and the anti-rejection process that protects the fetus from the maternal immune system. There are two types of G-protein-coupled CRH receptors (CRH-R1 and CRH-R2). Pyrrolopyrimidine compounds, such as antalarmin, have been developed as CRH-R1 receptor antagonists. Confirming the peripheral pro-inflammatory actions of CRH, antalarmin has been shown to suppress experimental aseptic inflammation. Thus, antalarmin may represent the first in a new class of anti-inflammatory agents operating through CRH-R1. Studies of CRH genetics have provided new insights on the pathogenesis of rheumatoid arthritis in humans. DNA variation across the CRH genecontaining region has been examined in families with multiple cases of rheumatoid arthritis. Transmission Disequilibrium Test analysis showed significant association at the CRH locus.European Journal of Endocrinology 155 S77-S84

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Prolonged periods without food intake during pregnancy increase risk for elevated maternal corticotropin-releasing hormone concentrations

Cited by 83 publications

References 25 publications

The Effect of Short Term Maternal Fasting on Fetal Biophysical and Neonatal Biochemical Profile - A Pilot Study and a Short Critical Review of the Literature

The Effect of Short Term Maternal Fasting on Fetal Biophysical and Neonatal Biochemical Profile - A Pilot Study and a Short Critical Review of the Literature

Maternal Ramadan Fasting and Neonatal Health

Corticotropin releasing hormone and the immune/inflammatory response

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