Prolonged Rate of Decay of Arterial Po2 Following Oxygen Breathing in Chronic Airways Obstruction

Changes in Arterial Blood Gases during and after a Period of Oxygen Breathing in Patients with Chronic Hypercapnic Respiratory Failure and in Patients with Asthma

“…In our patients it took on average 15 min for Pa,o, to return to baseline in patients with chronic hypercapnic respiratory failure and 10 min in patients with asthma, which agrees with the results of studies specifically designed to answer that question (Cugell, 1975;Howe, Alpert, Rickman, Spackman, Dexter & Dalen, 1975;Sherter, Jabbour, Kovnat & Snider, 1975 min of stopping 0,. In neither of these studies was Pa,o, followed for as long as 45 min after 0, breathing, but their figures suggest that Pa,o, was still falling and that with longer observation undershoots like those we have seen might have been observed.…”

Oxygenation equilibration time after alteration of inspired oxygen in critically ill patients

“…[4][5][6] However, patients with chronic obstructive pulmonary disease (COPD) experience equilibration times at a slower rate. 4,7 The aim of this study was to determine the time required for the arterial oxygen partial pressure (PaO 2 ) to reach equilibrium over time, after a .3 increase and decrease in FIO 2 , in mechanically ventilated patients in medical, surgical, or cancer ICUs, and to compare the equilibration oxygenation times between patients with a PaO 2 /FIO 2 ratio # 200 or > 200.…”

Time required for equilibration of arterial oxygen pressure after setting optimal positive end-expiratory pressure in acute respiratory distress syndrome

“…Clinicians are mainly concerned about the optimal time period to be allowed before obtaining a blood sample following a change in ventilatory settings. Pioneer studies on this issue were performed to evaluate the timing for the equilibration of oxygenation response after a change in FIO 2 , and these studies consistently indicated that a maximum of 10 mins is sufficient for equilibration except in patients with obstructive lung disease (1)(2)(3)(4)(5)(6).…”