Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

McBride, Todd A.; Gorin, Fredric A; Carlsen, Richard C.

doi:10.1016/0047-6374(95)01629-e

Cited by 80 publications

(88 citation statements)

References 26 publications

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“…The heightened susceptibility to damage observed here, coupled with an impaired ability to recover from injury or adapt to repeated exercise reported by others (Dedrick and Clarkson 1990;McBride et al 1995;Brooks and Faulkner 1990;Rader and Faulkner 2006;Lavender and Nosaka 2006b;Cutlip et al 2006) could be a contributor to the reduced lower limb muscle strength of elderly adults. Because contraction-induced damage impairs excitation-contraction coupling and cross-bridge function (Balnave and Allen 1995;Warren et al 1994), a heightened susceptibility to injury could initiate the age-related deterioration in muscle fiber activation and contractility (Delbono et al 1995;Wang et al 2002;Larsson et al 1997;Thompson and Brown 1999;Lowe et al 2001;Frontera et al 2000;Hook et al 2001;Krivickas et al 2001).…”

Section: Discussionsupporting

confidence: 51%

“…In addition to the acute effects of eccentric muscular activity, the ability to recover from injury and to adapt to this mode of contractile activity have been reported to be impaired in old animals and elderly human subjects (Cutlip et al 2006;McBride et al 1995;Dedrick and Clarkson 1990;Clarkson and Dedrick 1988;Lavender and Nosaka 2006b;Brooks and Faulkner 1990;Rader and Faulkner 2006). In fact, it has been proposed that an increased susceptibility to eccentric exercise and/or an impaired ability to recover and adapt may underlie the force deficits that are characteristic of old age (Brooks and Faulkner 1990).…”

Section: Introductionmentioning

confidence: 99%

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Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

Choi

Lim

Nibaldi

et al. 2011

AGE

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Muscles of old laboratory rodents experience exaggerated force losses after eccentric contractile activity. We extended this line of inquiry to humans and investigated the influence of fiber myosin heavy chain (MHC) isoform content on the injury process. Skinned muscle fiber segments, prepared from vastus lateralis biopsies of elderly men and women (78± 2 years, N=8), were subjected to a standardized eccentric contraction (strain, 0.25 fiber length; velocity, 0.50 unloaded shortening velocity). Injury was assessed by evaluating pre-and post-eccentric peak Ca 2+ -activated force per fiber cross-sectional area (F max ). Over 90% of the variability in post-eccentric F max could be explained by a multiple linear regression model consisting of an MHC-independent slope, where injury was directly related to pre-eccentric F max , and MHC-dependent y-intercepts, where the susceptibility to injury could be described as type IIa/IIx fibers>type IIa fibers>type I fibers. We previously reported that fiber type susceptibility to the same standardized eccentric protocol was type IIa/IIx>type IIa=type I for vastus lateralis fibers of 25-year-old adults (Choi and Widrick, Am J Physiol Cell Physiol 299:C1409-C1417, 2010). Modeling combined data sets revealed significant age by fiber type interactions, with posteccentric F max deficits greater for type IIa and type IIa/ IIx fibers from elderly vs. young subjects at constant pre-eccentric F max . We conclude that the resistance of the myofilament lattice to mechanical strain has deteriorated for type IIa and type IIa/IIx, but not for type I, vastus lateralis fibers of elderly adults.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

Choi

Lim

Nibaldi

et al. 2011

AGE

View full text Add to dashboard Cite

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“…Several studies have used skeletal muscle from rats and mice to investigate the effects of age on muscle function and recovery after fatiguing or damaging contraction protocols (Brooks & Faulkner, 1990;Gonzalez & Delbono, 2001;McBride, Gorin, & Carlsen, 1995). Researchers have also undertaken comparisons in muscle damage and fatigue, as well as repair and recovery, for humans of different ages (Allman & Rice, 2001;Clarkson & Dedrick, 1988;Dedrick & Clarkson, 1990).…”

Section: Damage and Repairmentioning

confidence: 99%

“…Tiidus also acknowledged, however, that training status could be an important factor in reducing the degree of postexercise damage in aging human muscle. Although several studies on animals have concluded that exercise-induced damage is greater in aging muscle (Brooks & Faulkner, 1990;McBride et al, 1995;Zerba et al), none of these studies have taken into account training status or activity levels, thereby neglecting to consider that differences in muscle damage might be associated with decreases in habitual physical activity (Galloway & Jokl, 2000). Clarkson and Dedrick (1988), in their comparison of muscle damage between young and aging women, concluded that the muscle-damage process takes a similar course for young and older women and that the repair process is equally effective, with older muscle demonstrating the same ability to adapt to damage incurred through repeated bouts of exercise as young muscle.…”

Section: Greater Exercise-induced Skeletal-muscle Damagementioning

confidence: 99%

The Effect of Aging on Skeletal-Muscle Recovery from Exercise: Possible Implications for Aging Athletes

Fell¹,

Williams²

2008

Journal of Aging and Physical Activity

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Recovery from exercise is integral to the physical training process. There is a perception among older athletes that aging negatively affects the recovery process. Plausible arguments for an impaired recovery with aging are a greater susceptibility of older muscle to exercise-induced skeletal-muscle damage and a slower repair and adaptation response. Differences in the physical activity level of the research participants are rarely considered, however. This makes it difficult to differentiate the respective roles of declining physical activity and aging on the recovery process. Furthermore, the type of exercise used to induce damage and monitor recovery is often not indicative of a normal training stimulus for athletes. This review discusses the effects of aging on skeletal-muscle damage and recovery processes and highlights the limitations of many of these studies with respect to older athletes. Future research should use an exercise intervention representative of a normal training stimulus and take the physical activity level of the participants into account.

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“…We also identified the following scientific evidence to support these views: (i) Age: It is widely reported that racehorses need time to recover from general physical stresses and exercise-related injuries (Evans, 2007). There is also much evidence that recovery times are longer for older muscles (e.g., McBride et al, 1995) and, particularly relevant for DBW, older individuals take much longer to recover muscle strength after strenuous exercise (Dedrick & Clarkson,1990). On the other hand, younger horses, due perhaps to under-developed bone or less controlled physical activity may be subject to more training injuries.…”

Section: Hypothesesmentioning

confidence: 99%

Time is money: Costing the impact of duration misperception in market prices

Tang

McGroarty

et al. 2016

European Journal of Operational Research

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We explore whether, and to what extent, traders in a real world financial market, where participants' judgements are reportedly well calibrated, are subject to duration misperception. To achieve this, we examine duration misperception in the horserace betting market. We develop a two-stage algorithm to predict horses' winning probabilities that account for a duration-related factor that is known to affect horses' winning prospects. The algorithm adapts survival analysis and combines it with the conditional logit model. Using a dataset of 4736 horseraces and the lifetime career statistics of the 53295 horses running in these races, we demonstrate that prices fail to discount fully information related to duration since a horse's last win. We show that this failure is extremely costly, since a betting strategy based on the predictions arising from the model shows substantial profits (932.5% and 16.27%, with and without reinvestment of winnings, respectively). We discuss the important implications of duration neglect in the wider economy. Highlights: Demonstrate existence of duration misperception in a real-world environment  Develop a 2-stage forecasting model combining survival analysis & conditional logit  Employ survival analysis to study pricing efficiency in a speculative market  Evaluate the economic costs of duration misperception in a financial market

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Prolonged recovery and reduced adaptation in aged rat muscle following eccentric exercise

Cited by 80 publications

References 26 publications

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults

The Effect of Aging on Skeletal-Muscle Recovery from Exercise: Possible Implications for Aging Athletes

Time is money: Costing the impact of duration misperception in market prices

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